Patents by Inventor Roy Coniglione
Roy Coniglione has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7922646Abstract: An implantable source (40) of therapeutic radiation for brachytherapy is provided as a sealed, biocompatible capsule (410) of plastic (e.g. polyethylene or PEEK) transparent to the radiation. The capsule contains a radiation source (400) comprising particles of a radioactive isotope (e.g. Pd103, I125, Cs131) in a fluid carrier that is resistant to radiation polymerization but solidifies at elevated temperature. It also has a marker (420), and desirably has a socket (430) which accommodates attaching spacers (660) and makes possible linear strands and planar arrays of the capsules. The spacers may be functional, e.g. heat-generating or medication-releasing.Type: GrantFiled: August 20, 2004Date of Patent: April 12, 2011Assignee: International Brachytherapy, S.A.Inventors: John L. Russell, Jr., John L. Carden, Jr., Roy Coniglione, Dominique Moyaux
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Publication number: 20060224035Abstract: An implantable source (40) of therapeutic radiation for brachytherapy is provided as a sealed, biocompatible capsule (410) of plastic (e.g. polyethylene or PEEK) transparent to the radiation. The capsule contains a radiation source (400) comprising particles of a radioactive isotope (e.g. Pd103, I125, Cs131) in a fluid carrier that is resistant to radiation polymerization but solidifies at elevated temperature. It also has a marker (420), and desirably has a socket (430) which accommodates attaching spacers (660) and makes possible linear strands and planar arrays of the capsules. The spacers may be functional, e.g. heat-generating or medication-releasing.Type: ApplicationFiled: August 20, 2004Publication date: October 5, 2006Applicant: International Brachytherapy, s.a.Inventors: John Russell Jr, John Carden Jr, Roy Coniglione, Dominque Moyaux
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Publication number: 20060067882Abstract: Therapeutic sources for use in the practice of brachytherapy comprise a radioactive composite that includes (a) a polymeric matrix and (b) a radioactive powder, e.g. Pd-103 or I-125, consisting essentially of very fine radioactive particles that are randomly and essentially uniformly dispersed within the polymeric matrix. The composite may be in the shape of one or more solid cylindrical rods surrounded by a non-radioactive sleeve. Alternatively it may be a hollow rod, suture, film, sheet, or microspheroidal particles.Type: ApplicationFiled: November 18, 2005Publication date: March 30, 2006Inventors: John Russell, Roy Coniglione
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Patent number: 6986880Abstract: Therapeutic sources for use in the practice of brachytherapy comprise a radioactive composite that includes (a) a polymeric matrix and (b) a radioactive powder, e.g. Pd-103 or I-125, consisting essentially of very fine radioactive particles that are randomly and essentially uniformly dispersed within the polymeric matrix. The composite may be in the shape of one or more solid cylindrical rods surrounded by a non-radioactive sleeve. Alternatively it may be a hollow rod, suture, film, sheet, or microspheroidal particles. The composite may be shaped by molding, extrusion or other methods, may be made with a flexibility suitable to its intended use or may be encapsulated in a metallic capsule.Type: GrantFiled: July 7, 2003Date of Patent: January 17, 2006Assignee: International Brachytherapy, s.a.Inventors: Roy Coniglione, John Russell
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Publication number: 20040076579Abstract: Therapeutic sources for use in the practice of brachytherapy comprise a radioactive composite that includes (a) a polymeric matrix and (b) a radioactive powder, e.g. Pd-103 or I-125, consisting essentially of very fine radioactive particles that are randomly and essentially uniformly dispersed within the polymeric matrix. The composite may be in the shape of one or more solid cylindrical rods surrounded by a non-radioactive sleeve. Alternatively it may be a hollow rod, suture, film, sheet, or microspheroidal particles. The composite may be shaped by molding, extrusion or other methods, may be made with a flexibility suitable to its intended use or may be encapsulated in a metallic capsule.Type: ApplicationFiled: July 7, 2003Publication date: April 22, 2004Inventors: Roy Coniglione, John Russell
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Patent number: 6589502Abstract: Therapeutic sources for use in the practice of brachytherapy are fabricated from radioactive composites of a radioactive powder of palladium-103, yttrium-90, phosphorus-32 or gold-198 and a biocompatible polymeric matrix. The particles of radioactive powder are dispersed within the polymer essentially randomly throughout a particular volume. The polymeric matrix is desirably manufactured with preselected flexibility suitable to its intended use, e.g. in the form of a rod, hollow rod, suture, film, sheet, or microspheroidal particles. The radioactive composites produce therapeutic sources which generate a radiation field that is substantially uniform in all directions. The therapeutic source may assembled from the radioactive composite during a medical procedure to emit the desired amount of therapeutic radiation. Optionally, the polymer is selected to dissolve or degrade in the body at a predetermined rate, the rate chosen depending upon the half life of the radioisotope used in the therapeutic source.Type: GrantFiled: November 27, 1995Date of Patent: July 8, 2003Assignee: International Brachytherapy s.a.Inventors: Roy Coniglione, John L. Russell, Jr.
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Patent number: 6347443Abstract: A method of making a sealed double-walled tubular precursor device that is adapted to be transmuted into a brachytherapy device is disclosed. The device is hollow-tube-shaped, allowing the easy association of the device with suture material. Disclosed are methods of making devices that can be rendered radioactive by the transmuting effects of irradiation by a cyclotron or nuclear reactor. The brachytherapy devices facilitate medical application and improve safety for patients and medical personnel.Type: GrantFiled: December 22, 2000Date of Patent: February 19, 2002Assignee: International Brachytherapy S.A.Inventor: Roy Coniglione
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Publication number: 20010005930Abstract: A method of making a sealed double-walled tubular precursor device that is adapted to be transmuted into a brachytherapy device is disclosed. The device is hollow-tube-shaped, allowing the easy association of the device with suture material. Disclosed are methods of making devices that can be rendered radioactive by the transmuting effects of irradiation by a cyclotron or nuclear reactor. The brachytherapy devices facilitate medical application and improve safety for patients and medical personnel.Type: ApplicationFiled: December 22, 2000Publication date: July 5, 2001Inventor: Roy Coniglione
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Patent number: 6163947Abstract: A method of making a novel brachytherapy device is disclosed. The device is formed from a hollow-tube-shaped seed-substrate, allowing the easy association of the device with suture material. This shape minimizes the chance of migration of implanted seeds due to better attachment to tissue. The distribution of the radioactive material on the exterior surface of an interior tube of the tubular device provides a relatively uniform radiation field around the hollow-tube-shaped brachytherapy seed source. Methods are disclosed of making brachytherapy devices that are inherently radioactive. Also disclosed are methods of making devices that can be rendered radioactive by the transmuting effects of neutron irradiation. Brachytherapy devices are disclosed that facilitate medical application and improve safety for patients and medical personnel.Type: GrantFiled: July 31, 1997Date of Patent: December 26, 2000Assignee: International Brachytherapy S.A.Inventor: Roy Coniglione
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Patent number: 5713828Abstract: A novel brachytherapy device is formed from a hollow-tube-shaped seed-substrate, allowing the easy association of the device with suture material. This shape minimizes the chance of migration of implanted seeds due to better attachment to tissue. The distribution of the radioactive material on the exterior surface of the tubular device provides a relatively uniform radiation field around the hollow-tube-shaped brachytherapy seed source. Brachytherapy devices are described that are inherently radioactive. Also disclosed are devices that can be rendered radioactive by the transmuting effects of neutron irradiation. Brachytherapy devices are discussed that facilitate medical application and improve safety for patients and medical personnel.Type: GrantFiled: November 27, 1995Date of Patent: February 3, 1998Assignee: International Brachytherapy s.aInventor: Roy Coniglione
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Patent number: 3951313Abstract: A reservoir or container of unitary construction having a predetermined volume of diluent disposed therein is disclosed. The reservoir includes a shearable cap or closure which, once removed, cannot be reassembled. The reservoir is provided with an access opening arranged and constructed to receive a capillary pipette assembly having a predetermined volume of sample so that an accurate mixture of diluent and sample is obtained. The reservoir may also be used as a sample cup for automated analyzers.Type: GrantFiled: June 5, 1974Date of Patent: April 20, 1976Assignee: Becton, Dickinson and CompanyInventor: Roy Coniglione