Patents by Inventor Roy Curtiss, III

Roy Curtiss, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety
    Patent number: 11920139
    Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Grant
    Filed: October 14, 2021
    Date of Patent: March 5, 2024
    Assignees: The Washington University, The Arizona Board of Regents for and on Behalf of Arizona State University
    Inventors: Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
  • Induction of protective immunity against antigens
    Patent number: 11788056
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Grant
    Filed: March 26, 2021
    Date of Patent: October 17, 2023
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Shifeng Wang
  • Food safety vaccine to control and reduce in poultry
    Patent number: 11766475
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: September 26, 2023
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Soo-Young Wanda
  • Ichthyophthirius multifiliis vaccine system
    Patent number: 11628213
    Abstract: Disclosed herein are nucleic acids, vector systems, and vaccines for vaccinating fresh water and marine fish using Ichthyophthirius multifiliis (Ich) i-antigens. In particular, a recombinant attenuated Edwardsiella vaccine (RAEV) vector system is disclosed with regulated delayed attenuation and regulated delayed lysis in vivo attributes that synthesizes Ich protective antigens to enable vaccination of fresh water and marine fish species susceptible to white spot disease. This vaccine construct is designed to exhibit the invasive properties of virulent Edwardsiella at the time of bath immunization and then is programmed to gradually lose virulence attributes and to synthesize protective antigens as a consequence of in vivo cell division as the RAEV colonizes internal effector lymphoid tissues. The ultimate lysis in vivo delivers a bolus of protective antigen along with immunostimulatory molecules to exhibit complete biological containment with no potential for survival in vivo or ex vivo.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: April 18, 2023
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Roy Curtiss, III, Banikalyan Swain
  • Induction of protective immunity against antigens
    Patent number: 11596677
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens from Clostridium Perfringens as vaccines to prevent necrotic enteritis (NE).
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: March 7, 2023
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Shifeng Wang
  • Induction of protective immunity against antigens
    Patent number: 11547751
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens from Clostridium Perfringens as vaccines to prevent necrotic enteritis (NE).
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: January 10, 2023
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Shifeng Wang
  • REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY
    Publication number: 20220090097
    Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Application
    Filed: October 14, 2021
    Publication date: March 24, 2022
    Inventors: Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
  • LIVE SELF-DESTRUCTING BACTERIAL ADJUVANTS TO ENHANCE INDUCTION OF IMMUNITY
    Publication number: 20220001008
    Abstract: Disclosed herein are unique adjuvant compositions comprising an attenuated derivative of a bacterial pathogen that undergoes lysis in vivo. In exemplary embodiments, the bacterial pathogen is a Salmonella spp. Also disclosed are methods for enhancing an immune response using the adjuvants disclosed herein.
    Type: Application
    Filed: November 4, 2019
    Publication date: January 6, 2022
    Inventor: Roy CURTISS, III
  • Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety
    Patent number: 11180765
    Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Grant
    Filed: August 11, 2020
    Date of Patent: November 23, 2021
    Assignees: The Arizona Board of Regents for and on behalf of Arizona State University, The Washington University
    Inventors: Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
  • Protective anti-ZIKV vaccine without inducing cross-reactions with dengue
    Patent number: 11136354
    Abstract: The subject application provides a genetically modified recombinant facultative intracellular invasive bacterial pathogen (RFIIBP) or a recombinant attenuated Salmonella vaccine (RASV) strains encoding Zika virus (ZIKV) antigens. These strains exhibit high immunogenicity, complete safety, and attenuation, and are unable to persist or be shed in an infective or viable form. These RFIIBPs and RASVs also exhibit regulated delayed attenuation in vivo, regulated delayed in vivo synthesis of protective ZIKV antigens. Methods of inducing mucosal, systemic and cellular immunities in hosts are also provided and antibodies produced using the disclosed RFIIBPs and RASVs can comprise neutralizing antibodies against ZIKV that do not crossreact with Dengue virus (DENV).
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: October 5, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventor: Roy Curtiss, III
  • INDUCTION OF PROTECTIVE IMMUNITY AGAINST ANTIGENS
    Publication number: 20210284955
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Application
    Filed: March 26, 2021
    Publication date: September 16, 2021
    Inventors: Roy Curtiss, III, Shifeng Wang
  • FOOD SAFETY VACCINE TO CONTROL SALMONELLA ENTERICA AND REDUCE CAMPYLOBACTER IN POULTRY
    Publication number: 20210283235
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
    Type: Application
    Filed: March 22, 2021
    Publication date: September 16, 2021
    Inventors: Roy Curtiss, III, Soo-Young Wanda
  • Food safety vaccine to control and reduce campylobacter in poultry
    Patent number: 11000583
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: May 11, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Soo-Young Wanda
  • Induction of protective immunity against antigens
    Patent number: 10988729
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: April 27, 2021
    Assignee: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Shifeng Wang
  • ICHTHYOPHTHIRIUS MULTIFILIIS VACCINE SYSTEM
    Publication number: 20210093704
    Abstract: Disclosed herein are nucleic acids, vector systems, and vaccines for vaccinating fresh water and marine fish using Ichthyophthirius multifiliis (Ich) i-antigens. In particular, a recombinant attenuated Edwardsiella vaccine (RAEV) vector system is disclosed with regulated delayed attenuation and regulated delayed lysis in vivo attributes that synthesizes Ich protective antigens to enable vaccination of fresh water and marine fish species susceptible to white spot disease. This vaccine construct is designed to exhibit the invasive properties of virulent Edwardsiella at the time of bath immunization and then is programmed to gradually lose virulence attributes and to synthesize protective antigens as a consequence of in vivo cell division as the RAEV colonizes internal effector lymphoid tissues. The ultimate lysis in vivo delivers a bolus of protective antigen along with immunostimulatory molecules to exhibit complete biological containment with no potential for survival in vivo or ex vivo.
    Type: Application
    Filed: January 23, 2019
    Publication date: April 1, 2021
    Inventors: Roy CURTISS, III, Banikalyan SWAIN
  • REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY
    Publication number: 20200377897
    Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Application
    Filed: August 11, 2020
    Publication date: December 3, 2020
    Inventors: Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
  • INDUCTION OF PROTECTIVE IMMUNITY AGAINST ANTIGENS
    Publication number: 20200368339
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens from Clostridium Perfringens as vaccines to prevent necrotic enteritis (NE).
    Type: Application
    Filed: August 3, 2018
    Publication date: November 26, 2020
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: Roy Curtiss, III, Shifeng Wang
  • Regulated expression of antigen and/or regulated attenuation to enhance vaccine immunogenicity and/or safety
    Patent number: 10774334
    Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: September 15, 2020
    Assignees: Arizona Broad of Regents on Behalf of Arizona State University, The Washington University
    Inventors: Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
  • REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY
    Publication number: 20200165620
    Abstract: The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.
    Type: Application
    Filed: December 5, 2019
    Publication date: May 28, 2020
    Inventors: Roy Curtiss, III, Shifeng Wang, Soo-Young Wanda, Wei Kong
  • A FOOD SAFETY VACCINE TO CONTROL SALMONELLA ENTERICA AND REDUCE CAMPYLOBACTER IN POULTRY
    Publication number: 20200009240
    Abstract: Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.
    Type: Application
    Filed: January 26, 2018
    Publication date: January 9, 2020
    Inventors: Roy Curtiss, III, Soo-Young Wanda