Patents by Inventor Roy Dar

Roy Dar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF
    Publication number: 20190145960
    Abstract: HIV-1's ability to enter a transcriptionally dormant state and establish a reservoir of latently infected cells is considered the major barrier to eradicating the virus from infected patients. Stochastic noise (i.e. fluctuations) in an HIV-1 transcriptional positive-feedback loop is one mechanism that enables HIV-1 to establish latency. Here, Applicants demonstrate that small-molecule modulation of noise in HIV-1 gene expression radically perturbs HIV-1 latency.
    Type: Application
    Filed: November 29, 2018
    Publication date: May 16, 2019
    Inventors: Leor Weinberger, Roy Dar
  • Compositions, systems and methods for gene expression noise drug screening and uses thereof
    Patent number: 10184933
    Abstract: HIV-1's ability to enter a transcriptionally dormant state and establish a reservoir of latently infected cells is considered the major barrier to eradicating the virus from infected patients. Stochastic noise (i.e. fluctuations) in an HIV-1 transcriptional positive-feedback loop is one mechanism that enables HIV-1 to establish latency. Here, Applicants demonstrate that small-molecule modulation of noise in HIV-1 gene expression radically perturbs HIV-1 latency.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: January 22, 2019
    Assignee: The J. David Gladstone Industries
    Inventors: Leor Weinberger, Roy Dar
  • COMPOSITIONS, SYSTEMS AND METHODS FOR GENE EXPRESSION NOISE DRUG SCREENING AND USES THEREOF
    Publication number: 20160245796
    Abstract: HIV-1's ability to enter a transcriptionally dormant state and establish a reservoir of latently infected cells is considered the major barrier to eradicating the virus from infected patients. Stochastic noise (i.e. fluctuations) in an HIV-1 transcriptional positive-feedback loop is one mechanism that enables HIV-1 to establish latency. Here, Applicants demonstrate that small-molecule modulation of noise in HIV-1 gene expression radically perturbs HIV-1 latency.
    Type: Application
    Filed: October 1, 2014
    Publication date: August 25, 2016
    Applicant: THE J. DAVID GLADSTONE INSTITUTES
    Inventors: Leor Weinberger, Roy Dar