Abstract: Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.

Abstract: Systems and methods are provided for creating and executing a decision network that includes a number of stations configured to operate with respect to an instance of a document, container or other object. A user interface may be presented to a user that includes selectable options for configuring and connecting stations within the decision network, and for establishing executable logic for each station to modify or create data within fields of a container instance. Different stations in the decision network may be assigned different permissions with respect to the container. Individual stations in the decision network may be configured to determine a prediction or probability based on data accessible to the given station, where the prediction or probability of one station may be based in part on an earlier prediction or probability determined at another station of the decision network.

Abstract: The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid salts or phytates to inorganic phosphates to improve metal solubility and reduce deposition within processing equipment.

Abstract: The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid salts or phytates to inorganic phosphates to improve metal solubility and reduce deposition within processing equipment.

Abstract: Folding apparatus (1) for folding sheet packaging elements (2), comprising main conveying means (12), configured to sequentially receive the packaging elements (2) from a feeding station (13) and to advance each packaging element (2) along a first path (A), forming means (15), carried by the main conveying means (12) and configured to cooperate in use with a first face (2b) of each packaging element (2) while the packaging element (2) is advanced along the first path (A), and folding means (18), advanced by auxiliary conveying means (16) along a second path (Q), having a first portion (Q1) distinct from the first path (A) and a second portion (Q2), which is in common with the first path (A) and along which the folding means (18) cooperate with a second face (2a), opposite the first face (2b), of each packaging element (2) to fold the packaging element (2) against the forming means (15).

Abstract: A composition is described herein that includes a polysiloxane, a silicon based crosslinker, a reinforcement filler, a vulcanization catalyst, and a repair-enabling filler. Methods of using such a composition are also described.

Abstract: The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid salts or phytates to inorganic phosphates to improve metal solubility and reduce deposition within processing equipment.

Abstract: A sheath at the end of an endoscope may be elastically expanded to clear an area within a body cavity during a medical procedure and retracted to within an envelope of the endoscope when not in use. In the expanded state, the sheath may provide sufficient mechanical strength to clear space for a camera or surgical tool, while also having sufficient pliability to mitigate impact on surrounding, sensitive tissue. In an example embodiment, the sheath may be an elastomeric sheath or the like coupled between portions of coaxial shafts of an endoscope, and the coaxial shafts can move relative to one another to deploy or retract the sheath by relatively tensioning and relaxing opposing ends of the sheath. In this manner, the sheath may be selectively expanded and retracted without exposed moving parts or sharp edges.

Abstract: A steerable endoscopic tool uses concentric sleeves of varying curvature to steer a tool tip toward or in the direction of a location of surgical interest. By rotating and/or axially displacing such sleeves relative to one another the tool tip may be maneuvered within a current field of view with several degrees of freedom without any physical movement of an endoscope, thus facilitating improved surgical access and control without complex mechanical systems in the endoscope or at the surgical site.

Abstract: The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid salts or phytates to inorganic phosphates to improve metal solubility and reduce deposition within processing equipment.

Abstract: There is described a magazine (1) for sheet packaging elements (2) in which side portions (4a) of said packaging elements (2) are held in a vertical position by transport and support branches (15, 18, 20) of main and secondary units (6, 8, 9) and said packaging elements (2) are advanced in respective conveying spaces (16, 19, 21) along a path (P) parallel to said transport and support branches (15, 18, 20) of said main and secondary units (6, 8, 9). The packaging elements (2) are advanced along said path (P) from an inlet section (7) to an outlet section (12). During conveying, batches (3) of packaging elements (2) are formed between an accumulation unit (8) and an auxiliary conveying unit (9) so that said packaging elements (2) are advanced in said batches (3) towards an end packaging station.

Abstract: A variety of tools and techniques are provided to support removal of ligamentum flavum in a spinal canal and other, similar tissue removal procedures.

Abstract: Folding apparatus (1) for folding sheet packaging elements (2), comprising main conveying means (12), configured to sequentially receive the packaging elements (2) from a feeding station (13) and to advance each packaging element (2) along a first path (A), forming means (15), carried by the main conveying means (12) and configured to cooperate in use with a first face (2b) of each packaging element (2) while the packaging element (2) is advanced along the first path (A), and folding means (18), advanced by auxiliary conveying means (16) along a second path (Q), having a first portion (Q1) distinct from the first path (A) and a second portion (Q2), which is in common with the first path (A) and along which the folding means (18) cooperate with a second face (2a), opposite the first face (2b), of each packaging element (2) to fold the packaging element (2) against the forming means (15).

Abstract: There is described a magazine (1) for sheet packaging elements (2) in which side portions (4a) of said packaging elements (2) are held in a vertical position by transport and support branches (15, 18, 20) of main and secondary units (6, 8, 9) and said packaging elements (2) are advanced in respective conveying spaces (16, 19, 21) along a path (P) parallel to said transport and support branches (15, 18, 20) of said main and secondary units (6, 8, 9). The packaging elements (2) are advanced along said path (P) from an inlet section (7) to an outlet section (12). During conveying, batches (3) of packaging elements (2) are formed between an accumulation unit (8) and an auxiliary conveying unit (9) so that said packaging elements (2) are advanced in said batches (3) towards an end packaging station.

Abstract: Compositions for inhibiting the corrosion of metals in contact with an aqueous system are provided. The corrosion inhibiting compositions may be used to maintain effective amounts of (1) an amino acid-based polymer, such as a polyaspartic acid compound, and (2) a dispersible and/or soluble tin compound in the aqueous system. The corrosion inhibiting compositions include the amino acid-based polymer and a dispersible and/or soluble tin compound and may optionally include a polycarboxylic acid chelating agent and/or a carboxylate/sulfonate functional copolymer.

Abstract: The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid salts or phytates to inorganic phosphates to improve metal solubility and reduce deposition within processing equipment.

Abstract: A variety of tools and techniques are provided to support removal of ligamentum flavum in a spinal canal and other, similar tissue removal procedures.

Abstract: Methods for inhibiting the corrosion of metals in contact with an aqueous system are provided. The method of inhibiting corrosion includes maintaining effective amounts of (1) an amino acid-based polymer, such as a polyaspartic acid compound, and (2) a dispersible and/or soluble tin compound in the aqueous system. The corrosion inhibiting components of the treatment may be added simultaneously or separately into the water of the aqueous system, i.e., provided either in a single treatment product or as separate products. Such a corrosion inhibiting method may optionally also include adding a polycarboxylic acid chelating agent and/or a carboxylate/sulfonate functional copolymer to the aqueous system.

Abstract: Compositions for inhibiting the corrosion of metals in contact with an aqueous system are provided. The corrosion inhibiting compositions may be used to maintain effective amounts of (1) an amino acid-based polymer, such as a polyaspartic acid compound, and (2) a dispersible and/or soluble tin compound in the aqueous system. The corrosion inhibiting compositions include the amino acid-based polymer and a dispersible and/or soluble tin compound and may optionally include a polycarboxylic acid chelating agent and/or a carboxylate/sulfonate functional copolymer.

Abstract: The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid salts or phytates to inorganic phosphates to improve metal solubility and reduce deposition within processing equipment.