Patents by Inventor Roy L. Hopfer

Roy L. Hopfer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liposome-incorporated mepartricin
    Patent number: 4981690
    Abstract: The present invention involves a liposomal agent for treating disseminated fungal infection in an animal. This liposomal agent comprises the polyene antifungal compound mepartricin. The mepatricin is encapsulated within a liposome. The liposome in which the mepartricin is incorporated is preferably a stable multilamellar vesicle. The liposome broadly comprises one or more lipids one or more of phosphomonoglyceride, phosphatidic acid and sphingolipid. The lipids are preferably one or more of phosphatidylcholine, phosphatidylserine, phosphatidylglycerol, sphingomyelin or phosphatidic acid. The lipids are most preferably one or more of dimyristoylphosphatidylchlorine, dimyristoylphosphatidylglycerol, phosphatidylcholine and phosphatidylglycerol. The liposome of the present invention may comprise a sterol most preferably cholesterol. An important aspect of the present invention involves a method for treating disseminated fungal infection in an animal.
    Type: Grant
    Filed: October 27, 1987
    Date of Patent: January 1, 1991
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gabriel Lopez-Berestein, Reeta Mehta, Roy L. Hopfer, Rudolph L. Juliano
  • Composition and method for treatment of disseminated fungal infections in mammals
    Patent number: 4978654
    Abstract: A method is disclosed for treatment of disseminated fungal infection in a mammal comprising the administration of a fungicidally effective amount of Amphotericin B encapsulated in a substantially sterol-free liposome to the infected mammal. Also provided is an agent for treatment of disseminated fungal infection in a mammal comprising Amphotericin B encapsulated in a liposome which consists essentially of lipids other than sterols.
    Type: Grant
    Filed: January 12, 1987
    Date of Patent: December 18, 1990
    Assignee: Board of Regents, The University of Texas System
    Inventors: Gabriel Lopez-Berestein, Victor Fainstein, Evan M. Hersh, Roy L. Hopfer, Rudolph L. Juliano, Kapil Mehta, Reeta Mehta
  • Liposome-incorporated nystatin
    Patent number: 4812312
    Abstract: The present invention involves a liposomal agent for treating disseminated fungal infection in an animal. This liposomal agent comprises the polyene antifungal compound nystatin. The nystatin is encapsulated within a liposome. The liposome in which the nystatin is incorporated is preferably a stable multilamellar vesicle. The liposome broadly comprises one or more lipids one or more of phosphomonoglyceride, phosphatidic acid and sphingolipid. The lipids are preferably one or more of phosphatidylcholine, phosphatidylserine, phosphatidylglycerol, sphingomyelin or phosphatidic acid. The lipids are most preferably one or more of dimyristoylphosphatidylcholine, dimyristoylphosphatidylglycerol, phosphatidylcholine and phosphatidylglycerol. The liposome of the present invention may comprise a sterol most preferably cholesterol. An important aspect of the present invention involves a method for treating disseminated fungal infection in an animal.
    Type: Grant
    Filed: March 3, 1987
    Date of Patent: March 14, 1989
    Assignee: Board of Regents of the University of Texas System
    Inventors: Gabriel Lopez-Berestein, Reeta Mehta, Roy L. Hopfer, Rudolph L. Juliano
  • Composition and method for treatment of disseminated fungal infections in mammals
    Patent number: 4663167
    Abstract: Method for treatment of disseminated fungal infection in a mammal comprising the administration of a fungicidally effective amount of Amphotericin B encapsulated in a substantially sterol-free liposome to the infected mammal. Also provided is an agent for treatment of disseminated fungal infection in a mammal comprising liposome-encapsulated Amphotericin B, said liposome being comprised of lipids other than sterols.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: May 5, 1987
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Gabriel Lopez-Berestein, Victor Fainstein, Evan M. Hersh, Roy L. Hopfer, Rudolph L. Juliano, Kapil Mehta, Reeta Mehta