Abstract: This disclosure concerns novel demethylpenclomedine analogs. Also disclosed are pharmaceutical compositions and methods for using such compositions to treat hyperproliferative disorders.

Abstract: The present disclosure relates to salts and compositions of isophosphoramide mustard and isophosphoramide mustard analogs. In one embodiment the salts can be represented by the formula wherein A+ represents an ammonium species selected from the protonated (conjugate acid) or quaternary forms of aliphatic amines and aromatic amines, including basic amino acids, heterocyclic amines, substituted and unsubstituted pyridines, guanidines and amidines; and X and Y independently represent leaving groups. Also disclosed herein are methods for making such compounds and formulating pharmaceutical compositions thereof. Methods for administering the disclosed compounds to subjects, particularly to treat hyperproliferative disorders, also are disclosed.

Abstract: An apparatus and method for allowing an operator of a portable infusion device continue to operate the device after the primary battery source becomes depleted. The invention contemplates providing a secondary, rechargeable battery in addition to the primary battery, to allow the infusion device to operate even in the instance of a sudden drop in primary battery voltage. The apparatus includes a housing accommodating a syringe, where the syringe contains a liquid to be infused. Also included is a motor, a drive system operatively connected to the motor, where the drive system advances a piston of the syringe in order to expel the liquid from a barrel of the syringe. A power source is in electrical contact with and supplies power to the motor. The power source includes a primary battery module, and a rechargeable battery module, wherein the primary battery source supplies power to the rechargeable battery module. The result is a fail-safe system of alerting the user of low or critical battery conditions.

Abstract: Devices for electrosurgery by means of oxy-hydro combustion. Deleterious effects to tissue are minimized by means of control of acid-base shift reactions, which reactions can further be employed to control oxy-hydro combustion reactions. In one embodiment, radiofrequency energy in electrical connection with electrodes is employed to induce electrolysis in an aqueous salt environment, thereby producing oxygen and hydrogen, with the same energy source employed to initiate a combustion reaction.

Abstract: An bipolar electrosurgical tool (10) for cauterizing or ablating tissue. The tool has a nose cone (12) which serves as a handle. A conductive shaft (14) extends from the nose cone. A tip assembly (18) with an active electrode (20) is mounted to the shaft. A circuit board (78) is mounted in the nose cone. Conductive traces that forming contact pads (96, 102) are formed on the circuit board. A web (108) formed from a single piece of elastomeric material is seated over the opening in which the printed circuit board is mounted to seal the opening shut. Integrally formed with the web are buttons (116, 118) that are in registration over the contact pads. The buttons can be depressed downwardly towards the contact pads. When a button is so depressed, a conductive landing pad (120) integral with the button closes the connection between the traces that form the contact pad. Thus, the tool of this invention is provided with switches. The circuit board also has two conductive traces (92, 104a) that run in parallel.

Abstract: Devices and methods for inserting at least a portion of a medical device in a patient are provided. Embodiments include medical device insertions that employ a plurality of insertion stages. Also provided are systems and kits for use in analyte monitoring.

Abstract: A method and device are disclosed for monitoring and/or altering an immune function. The method uses a resonance modulating compound as a coupling agent that is capable of interacting with the immune system to monitor or stimulate immune function. The resonance modulator has electromagnetic properties that attract immune cells to a target area to which the resonance modulating agent has been applied. Electromagnetic properties (such as a voltage amplitude) of the target region are altered in the presence of the resonance modulator, and serve as an indicator of immune function. An external stimulus (such as an applied electromagnetic field) can also be applied to the resonance modulator to enhance its immune stimulating and attractant properties. Particular examples of the resonance modulator are aryl hydrazones.

Abstract: Devices for electrosurgery by means of oxy-hydro combustion. Deleterious effects to tissue are minimized by means of control of acid-base shift reactions, which reactions can further be employed to control oxy-hydro combustion reactions. In one embodiment, radiofrequency energy in electrical connection with electrodes is employed to induce electrolysis in an aqueous salt environment, thereby producing oxygen and hydrogen, with the same energy source employed to initiate a combustion reaction.

Abstract: Devices for electrosurgery by means of oxy-hydro combustion and methods for use of such devices in electrosurgical procedures. Provided are devices for combustion of oxygen and hydrogen, or other hydrocarbon fuels, wherein oxygen and hydrogen may be generated by electrolysis or oxygen and hydrogen, or other hydrocarbon fuels, may be supplied, such devices including an ignition source and an adjustable and translatable sheath for controlling such reactions. Also provided is a detachable and positionable sheath for controlling reactions and minimizing tissue damage with conventional electrosurgery devices.

Abstract: Methods for electrosurgical electrolysis for treating tissue within a body, including methods that operate in an electrolyzable medium, including an aqueous electrolyzable medium, by means of electrolysis, and optionally by means of oxy-hydrogen combustion for use in treatment, including therapeutic methods of electrolysis to effect advantageous tissue changes.

Abstract: Devices and methods for electrolytic electrosurgery wherein a detector is located proximal to an active electrode on an electrosurgical probe, optionally disposed between the active electrode and a return electrode, the detector detecting at least on parameter relating to electrolysis. The detected parameter can include pH concentration, temperature, conductivity, impedance, ion, concentration, electrolytic gas consumption, electrolytic gas production, pressure or sound. The detected parameter can be employed in control systems to control systems to control activation or operation of the electrosurgical probe.

Abstract: An bipolar electrosurgical tool (10) for cauterizing or ablating tissue. The tool has a nose cone (12) which serves as a handle. A conductive shaft (14) extends from the nose cone. A tip assembly (18) with an active electrode (20) is mounted to the shaft. A circuit board (78) is mounted in the nose cone. Conductive traces that forming contact pads (96, 102) are formed on the circuit board. A web (108) formed from a single piece of elastomeric material is seated over the opening in which the printed circuit board is mounted to seal the opening shut. Integrally formed with the web are buttons (116, 118) that are in registration over the contact pads. The buttons can be depressed downwardly towards the contact pads. When a button is so depressed, a conductive landing pad (120) integral with the button closes the connection between the traces that form the contact pad. Thus, the tool of this invention is provided with switches. The circuit board also has two conductive traces (92, 104a) that run in parallel.

Abstract: An bipolar electrosurgical tool (10) for cauterizing or ablating tissue. The tool has a nose cone (12) which serves as a handle. A conductive shaft (14) extends from the nose cone. A tip assembly (18) with an active electrode (20) is mounted to the shaft. A circuit board (78) is mounted in the nose cone. Conductive traces that forming contact pads (96, 102) are formed on the circuit board. A web (108) formed from a single piece of elastomeric material is seated over the opening in which the printed circuit board is mounted to seal the opening shut. Integrally formed with the web are buttons (116, 118) that are in registration over the contact pads. The buttons can be depressed downwardly towards the contact pads. When a button is so depressed, a conductive landing pad (120) integral with the button closes the connection between the traces that form the contact pad. Thus, the tool of this invention is provided with switches. The circuit board also has two conductive traces (92, 104a) that run in parallel.

Abstract: An bipolar electrosurgical tool (10) for cauterizing or ablating tissue. The tool has a nose cone (12) which serves as a handle. A conductive shaft (14) extends from the nose cone. A tip assembly (18) with an active electrode (20) is mounted to the shaft. A circuit board (78) is mounted in the nose cone. Conductive traces that forming contact pads (96, 102) are formed on the circuit board. A web (108) formed from a single piece of elastomeric material is seated over the opening in which the printed circuit board is mounted to seal the opening shut. Integrally formed with the web are buttons (116, 118) that are in registration over the contact pads. The buttons can be depressed downwardly towards the contact pads. When a button is so depressed, a conductive landing pad (120) integral with the button closes the connection between the traces that form the contact pad. Thus, the tool of this invention is provided with switches. The circuit board also has two conductive traces (92, 104a) that run in parallel.

Abstract: An bipolar electrosurgical tool (10) for cauterizing or ablating tissue. The tool has a nose cone (12) which serves as a handle. A conductive shaft (14) extends from the nose cone. A tip assembly (18) with an active electrode (20) is mounted to the shaft. A circuit board (78) is mounted in the nose cone. Conductive traces that forming contact pads (96, 102) are formed on the circuit board. A web (108) formed from a single piece of elastomeric material is seated over the opening in which the printed circuit board is mounted to seal the opening shut. Integrally formed with the web are buttons (116, 118) that are in registration over the contact pads. The buttons can be depressed downwardly towards the contact pads. When a button is so depressed, a conductive landing pad (120) integral with the button closes the connection between the traces that form the contact pad. Thus, the tool of this invention is provided with switches. The circuit board also has two conductive traces (92, 104a) that run in parallel.

Abstract: A motor, preferably in the form of a pump, is primarily designed to be activated by the oscillating motion of waves and has a paddle disposed to oscillate about a stationary horizontal axis located in the plane of the paddle. The paddle is placed in the surf and so positioned where the wave action is greatest so that the force of the waves can act on the paddle to cause the paddle to oscillate back and forth, one cycle with each wave. Preferably, the paddle is disposed to depend from the stationary axis. This oscillating motion of the paddle is coupled to a suitable pump which pumps sea water. Preferably, the pump has a cylindrical housing concentric with the stationary axis. A radial vane is fixed to a shaft within the housing while the paddle is fixed to the shaft and disposed outside the housing. Suitable valves are provided in the housing to allow sea water to enter and exit under action of the oscillating vane.