Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: A biomechanical breast pump mechanism (1) for expressing breastmilk comprising a biomimetic funnel (2), at least two active actuation areas (23,24) on the funnel (2) and stationary areas (25), the active actuation areas (23,24) being actuatable by a driving mechanism or mechanisms (3) and being configured to replicate the complex functions of the infant's tongue during suckling namely the physical stimulation of the areola (17)/nipple (16); nipple positioning; creating and maintaining low-level baseline vacuum to create air-seal on the breast; generating sub-atmospheric pressure inside the funnel (2); creating and maintaining close-to-zero-air environment in the funnel (2); and control of the vacuum oscillation within predefined ranges coordinated negative and positive actuation (41,42) of one or both actuation areas (23,24) independently or simultaneously.

Abstract: A refractory device, such as a replacement purge plug containing a refractory material, is configured to be inserted in the bottom of a ladle for introducing purging gas through a heat of molten metal in a ladle. One or more geometrical features on the lateral surface of the purge plug facilitate the installation of the purge plug into a housing block that has been subjected to erosion.

Abstract: A refractory device, such as a replacement purge plug containing a refractory material, is configured to be inserted in the bottom of a ladle for introducing purging gas through a heat of molten metal in a ladle. One or more geometrical features on the lateral surface of the purge plug facilitate the installation of the purge plug into a housing block that has been subjected to erosion.

Abstract: An exemplary antenna system for an electromagnetic wave includes a conductor having a first portion and a second bent portion. The exemplary antenna system includes a first transformer connected to the second bent portion and configured to invert current of the second bent portion relative to current received from the first portion. An exemplary method for conducting an electromagnetic signal includes conducting an electromagnetic signal through a first portion and a second bent portion of a conductor. The exemplary method includes inverting current of the signal of the second bent portion relative to current received from the first portion. A wave created by current of the first portion can be added to a wave created by current of the second bent portion.

Abstract: An exemplary antenna system for an electromagnetic wave includes a conductor having a first portion and a second bent portion. The exemplary antenna system includes a first transformer connected to the second bent portion and configured to invert current of the second bent portion relative to current received from the first portion. An exemplary method for conducting an electromagnetic signal includes conducting an electromagnetic signal through a first portion and a second bent portion of a conductor. The exemplary method includes inverting current of the signal of the second bent portion relative to current received from the first portion. A wave created by current of the first portion can be added to a wave created by current of the second bent portion.

Abstract: A layered textile composite product is disclosed which may include a nonwoven needled layer. The nonwoven needled layer is comprised of mechanically interlocked staple fibers which are needled together on a needle punch machine and then bonded with an adhesive layer to a polymeric or polyolefin film layer. The overall layered textile product may be used in several different applications, including for example in automobiles for seating, load floor, trunk linings, floor carpeting, door panel trim, and other interior trim applications.

Abstract: Disclosed are methods of producing a supported organic catalyst system comprising the steps of: (a) providing an organic catalyst solution comprising an organic catalyst dissolved in a supercritical-like solvent; (b) contacting a support material with the organic catalyst solution; and (c) removing substantially all of the supercritical-like solvent from the organic catalyst and the support material.

Abstract: A composite fabric structure having unique visual and physical properties is described. The composite fabric includes a textile fabric layer having a visual surface and a rear surface. A layer of diffractive or retroreflective material is secured beneath the textile fabric layer, either directly or beneath a layer of substantially transparent material. The textile fabric layer is of an open or semi-transparent construction, so that light can pass through it to reach the layer of diffractive or retroreflective material and be reflected back through the layer of textile fabric, to provide a unique appearance to its visual surface. Because fabric constructions can be provided which are extremely conspicuous, they have particular utility in the formation of safety equipment and automobile components. Furthermore, the fabrics have high durability, improved hand, and in many embodiments can be stretched as well as molded.

Abstract: A composite fabric structure having unique visual and physical properties is described. The composite fabric includes a textile fabric layer having a visual surface and a rear surface. A layer of diffractive or retroreflective material is secured beneath the textile fabric layer, either directly or beneath a layer of substantially transparent material. The textile fabric layer is of an open or semi-transparent construction, so that light can pass through it to reach the layer of diffractive or retroreflective material and be reflected back through the layer of textile fabric, to provide a unique appearance to its visual surface. Because fabric constructions can be provided which are extremely conspicuous, they have particular utility in the formation of safety equipment and automobile components. Furthermore, the fabrics have high durability, improved hand, and in many embodiments can be stretched as well as molded. Methods for making composite fabrics and articles made therefrom are also described.

Abstract: Provided are methods of introducing environmentally desirable refrigerants into refrigeration systems. The present methods involve recharging a refrigerant system that contains a chlorine-containing refrigerant and a lubricant comprising the steps of (a) removing the chlorine-containing refrigerant from the refrigeration system while retaining a substantial portion of the lubricant in said system; and (b) introducing to said system a composition comprising: (i) a refrigerant; (ii) a surfactant; and (iii) a solubilizing agent.

Abstract: Disclosed are methods of producing supported organic catalyst systems which find particular use in polymerization reactions. The methods comprise generally, the steps of (a) providing an organic catalyst solution comprising an organic catalyst dissolved in a solvent; (b) contacting the organic catalyst solution with a solid support material; and (c) removing the solvent from the support material by using one or more supercritical-like solvents.

Abstract: Provided are methods of introducing environmentally desirable refrigerants into refrigeration systems. The present methods involve recharging a refrigerant system that contains a chlorine-containing refrigerant and a lubricant comprising the steps of (a) removing the chlorine-containing refrigerant from the refrigeration system while retaining a substantial portion of the lubricant in said system; and (b) introducing to said system a composition comprising: (i) a refrigerant; (ii) a surfactant; and (iii) a solubilizing agent.

Abstract: This invention relates to adhesion promotion compositions which provide excellent adhesive characteristics between rubber latices and flexible textile substrates. Such compositions comprise specific mixtures of capped isocyanates which react strongly and thoroughly with rubber latices to promote the adhesion of such latices to textile substrates. Such rubber latices provide the ability to increase the stretch characteristics of the target textile substrate while simultaneously permitting retention of a certain degree of rigidity. Such rubber/textile composites are useful within waistbands as they retain their stretch and rigidity very well even after repeated dry cleanings.

Abstract: A method for separating water from a chemical mixture is provided. In the process of the invention, water is separated from a chemical mixture by contacting the chemical mixture with a water-soluble polymer.

Abstract: Azeotrope-like compositions of trifluoromethane, carbon dioxide, ethane, and hexafluoroethane are provided. The compositions of the invention are environmentally desirable for use as refrigerants, aerosol propellants, blowing agents for polymer foam, heat transfer media, and gaseous dielectrics.