Patents by Inventor Roy S. Whaley

Roy S. Whaley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extended release pharmaceutical formulations
    Patent number: 5445829
    Abstract: An extended release pharmaceutical formulation adapted to approach zero order release of drug over a 12 to at least 24 hour period, comprised of a mixture of 0 to about 50% of an immediate release particle containing a drug, inert substrate and binder, coated with talc and up to 100% of an extended release particle comprising the immediate release particle coated with a dissolution modifying system containing plasticizers and a film forming agent.
    Type: Grant
    Filed: June 15, 1992
    Date of Patent: August 29, 1995
    Assignee: KV Pharmaceutical Company
    Inventors: George N. Paradissis, James A. Garegnani, Roy S. Whaley
  • Pharmaceutical formulation which does not induce tolerance
    Patent number: 5296232
    Abstract: A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core composed of a pharmaceutically acceptable, film forming polymer. The film forming polymer is effective to permit release of the organic nitrate from the spheres, over a daily dosing period, at a rate that achieves a therapeutically effective level of the organic nitrate, while effecting a drug holiday towards a latter portion of the daily dosing period so as not to induce tolerance.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: March 22, 1994
    Assignee: KV Pharmaceutical Company
    Inventors: George N. Paradissis, James A. Garegnani, Roy S. Whaley
  • Extended release pharmaceutical formulations
    Patent number: 5133974
    Abstract: An extended release pharmaceutical formulation adapted to approach zero order release of drug over a 12 to at least 24 hour period, comprised of a mixture of 0 to aobut 50% of an immediate release particle containing a drug, inert substrate and binder, coated with talc and up to 100% of an extended release particle comprising the immediate release particle coated with a dissolution modifying system containing plasticizers and a film forming agent.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: July 28, 1992
    Assignee: KV Pharmaceutical Company
    Inventors: George N. Paradissis, James A. Garegnani, Roy S. Whaley
  • Oral once-per-day organic nitrate formulation which does not induce tolerance
    Patent number: 5122384
    Abstract: A controlled-release organic nitrate formulation for once-per-day oral administration is provided by spheres having a core which includes an organic nitrate, and a membrane surrounding the core composed of a pharmaceutically acceptable, film forming polymer. The film forming polymer is effective to permit release of the organic nitrate from the spheres, over a daily dosing period, at a rate that achieves a therapeutically effective level of the organic nitrate, while effecting a drug holiday towards a latter portion of the daily dosing period so as not to induce tolerance.
    Type: Grant
    Filed: May 5, 1989
    Date of Patent: June 16, 1992
    Assignee: KV Pharmaceutical Company
    Inventors: George N. Paradissis, James A. Garegnani, Roy S. Whaley