Patents by Inventor Roy Sirkis

Roy Sirkis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONJUGATES OF CARBOXY POLYSACCHARIDES WITH FIBROBLAST GROWTH FACTORS AND VARIANTS THEREOF
    Publication number: 20170196986
    Abstract: Conjugates of hydrophilic carboxy polysaccharides with protein members of the fibroblast growth factor (FGF) family and variants thereof. The conjugates provide a modified bioactivity and stability of FGFs for various therapeutic applications.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 13, 2017
    Applicant: HEPACORE LTD.
    Inventors: Avner YAYON, Roy SIRKIS, Boaz AMIT, Avraham WORTZEL
  • Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
    Patent number: 9610357
    Abstract: Conjugates of hydrophilic carboxy polysaccharides with protein members of the fibroblast growth factor (FGF) family and variants thereof. The conjugates provide a modified bioactivity and stability of FGFs for various therapeutic applications.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: April 4, 2017
    Assignee: HEPACORE LTD.
    Inventors: Avner Yayon, Roy Sirkis, Boaz Amit, Avraham Wortzel
  • FGF-18 truncated variants having increased receptor specificity and uses thereof
    Patent number: 9226949
    Abstract: The present invention relates to fibroblast growth factor 18 (FGF-18) variants having various truncations beyond the signal peptide domain of the N-terminus, which activate FGFR3 with increased specificity. The invention further relates to polynucleotides encoding the variants, pharmaceutical compositions comprising same and methods for use thereof in treating cartilage and skeletal disorders.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: January 5, 2016
    Assignee: HEPACORE LTD.
    Inventors: Avner Yayon, Eran Rom, Roy Sirkis, Dalit Strauss-Ayali
  • Conjugates Of Carboxy Polysaccharides With Fibroblast Growth Factors And Variants Thereof
    Publication number: 20140038892
    Abstract: Conjugates of hydrophilic carboxy polysaccharides with protein members of the fibroblast growth factor (FGF) family and variants thereof. The conjugates provide a modified bioactivity and stability of FGFs for various therapeutic applications.
    Type: Application
    Filed: October 15, 2013
    Publication date: February 6, 2014
    Inventors: Avner Yayon, Roy Sirkis, Boaz Amit, Avraham Wortzel
  • FGF-18 Truncated Variants Having Increased Receptor Specificity And Uses Thereof
    Publication number: 20130225493
    Abstract: The present invention relates to fibroblast growth factor 18 (FGF-18) variants having various truncations beyond the signal peptide domain of the N-terminus, which activate FGFR3 with increased specificity. The invention further relates to polynucleotides encoding the variants, pharmaceutical compositions comprising same and methods for use thereof in treating cartilage and skeletal disorders.
    Type: Application
    Filed: March 21, 2013
    Publication date: August 29, 2013
    Inventors: Avner Yayon, Eran Rom, Roy Sirkis, Dalit Strauss-Ayali