Patents by Inventor Roy Vaz

Roy Vaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic compounds, compositions, and methods of using thereof
    Patent number: 12649750
    Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.
    Type: Grant
    Filed: September 12, 2025
    Date of Patent: June 9, 2026
    Assignees: Sionna Therapeutics Inc., Genzyme Corporation
    Inventors: Junkai Liao, John E. Macor, George Topalov, Mark Munson, Sukanthini Thurairatnam, Bradford Hirth, Zhongli Gao, Gregory Donald Hurlbut, Andrew Good, Roy Vaz, Jinyu Liu, Yi Li, Anatoly Ruvinsky, Michael Kothe, David Borcherding, Patrick Bernardelli, Arielle Genevois Borella, Franck Caussanel, Ingrid Devillers, Eric Nicolai, Franck Slowinski, Fabienne Thompson, Lothar Schwink, Heiner Glombik, Stefan Guessregen, Michael Podeschwa, Nils Rackelmann, Sven Ruf
  • Macrocyclic compounds, compositions, and methods of using thereof
    Patent number: 12624051
    Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.
    Type: Grant
    Filed: September 12, 2025
    Date of Patent: May 12, 2026
    Assignees: Genzyme Corporation, Sionna Therapeutics Inc.
    Inventors: Junkai Liao, John E. Macor, George Topalov, Mark Munson, Sukanthini Thurairatnam, Bradford Hirth, Zhongli Gao, Gregory Donald Hurlbut, Andrew Good, Roy Vaz, Jinyu Liu, Yi Li, Anatoly Ruvinsky, Michael Kothe, David Borcherding, Patrick Bernardelli, Arielle Genevois Borella, Franck Caussanel, Ingrid Devillers, Eric Nicolai, Franck Slowinski, Fabienne Thompson, Lothar Schwink, Heiner Glombik, Stefan Guessregen, Michael Podeschwa, Nils Rackelmann, Sven Ruf
  • MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF
    Publication number: 20260008786
    Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.
    Type: Application
    Filed: September 12, 2025
    Publication date: January 8, 2026
    Inventors: Junkai Liao, John E. Macor, George Topalov, Mark Munson, Sukanthini Thurairatnam, Bradford Hirth, Zhongli Gao, Gregory Donald Hurlbut, Andrew Good, Roy Vaz, Jinyu Liu, Yi Li, Anatoly Ruvinsky, Michael Kothe, David Borcherding, Patrick Bernardelli, Arielle Genevois Borella, Franck Caussanel, Ingrid Devillers, Eric Nicolai, Franck Slowinski, Fabienne Thompson, Lothar Schwink, Heiner Glombik, Stefan Guessregen, Michael Podeschwa, Nils Rackelmann, Sven Ruf
  • MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF
    Publication number: 20260008785
    Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.
    Type: Application
    Filed: September 12, 2025
    Publication date: January 8, 2026
    Inventors: Junkai Liao, John E. Macor, George Topalov, Mark Munson, Sukanthini Thurairatnam, Bradford Hirth, Zhongli Gao, Gregory Donald Hurlbut, Andrew Good, Roy Vaz, Jinyu Liu, Yi Li, Anatoly Ruvinsky, Michael Kothe, David Borcherding, Patrick Bernardelli, Arielle Genevois Borella, Franck Caussanel, Ingrid Devillers, Eric Nicolai, Franck Slowinski, Fabienne Thompson, Lothar Schwink, Heiner Glombik, Stefan Guessregen, Michael Podeschwa, Nils Rackelmann, Sven Ruf
  • MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF
    Publication number: 20250248975
    Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.
    Type: Application
    Filed: March 5, 2025
    Publication date: August 7, 2025
    Inventors: Junkai Liao, John E. Macor, George Topalov, Mark Munson, Sukanthini Thurairatnam, Bradford Hirth, Zhongli Gao, Gregory Donald Hurlbut, Andrew Good, Roy Vaz, Jinyu Liu, Yi Li, Anatoly Ruvinsky, Michael Kothe, David Borcherding, Patrick Bernardelli, Arielle Genevois Borella, Franck Caussanel, Ingrid Devillers, Eric Nicolai, Franck Slowinski, Fabienne Thompson, Lothar Schwink, Heiner Glombik, Stefan Guessregen, Michael Podeschwa, Nils Rackelmann, Sven Ruf
  • MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF
    Publication number: 20250197422
    Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.
    Type: Application
    Filed: March 5, 2025
    Publication date: June 19, 2025
    Inventors: Junkai Liao, John E. Macor, George Topalov, Mark Munson, Sukanthini Thurairatnam, Bradford Hirth, Zhongli Gao, Gregory Donald Hurlbut, Andrew Good, Roy Vaz, Jinyu Liu, Yi Li, Anatoly Ruvinsky, Michael Kothe, David Borcherding, Patrick Bernardelli, Arielle Genevois Borella, Franck Caussanel, Ingrid Devillers, Eric Nicolai, Franck Slowinski, Fabienne Thompson, Lothar Schwink, Heiner Glombik, Stefan Guessregen, Michael Podeschwa, Nils Rackelmann, Sven Ruf
  • MACROCYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS OF USING THEREOF
    Publication number: 20250197420
    Abstract: The present disclosure includes, among other things, CFTR modulators, pharmaceutical compositions, and methods of making and using the same.
    Type: Application
    Filed: March 5, 2025
    Publication date: June 19, 2025
    Inventors: Junkai Liao, John E. Macor, George Topalov, Mark Munson, Sukanthini Thurairatnam, Bradford Hirth, Zhongli Gao, Gregory Donald Hurlbut, Andrew Good, Roy Vaz, Jinyu Liu, Yi Li, Anatoly Ruvinsky, Michael Kothe, David Borcherding, Lothar Schwink, Heiner Glombik, Stefan Guessregen, Michael Podeschwa, Nils Rackelmann, Sven Ruf
  • INDOLE COMPOUNDS AND METHODS OF USE
    Publication number: 20240279220
    Abstract: The invention relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.
    Type: Application
    Filed: March 1, 2024
    Publication date: August 22, 2024
    Inventors: Junkai Liao, Mark Munson, Sukanthini Thurairatnam, Bradford Hirth, Zhongli Gao, Gregory Hurlbut, David Borcherding, Matthieu Barrague, Timothy Alan Gillespy, Alexandre Gross, Andrew Good, Roy Vaz, Jinyu Liu, Yi Li, Markus Metz, Anatoly Ruvinsky, Claude Barberis
  • INDOLE COMPOUNDS AND METHODS OF USE
    Publication number: 20240239784
    Abstract: The invention relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.
    Type: Application
    Filed: March 1, 2024
    Publication date: July 18, 2024
    Inventors: Junkai Liao, Mark Munson, Sukanthini Thurairatnam, Bradford Hirth, Zhongli Gao, Gregory Hurlbut, David Borcherding, Matthieu Barrague, Timothy Alan Gillespy, Alexandre Gross, Thaddeus Nieduzak, Andrew Good, Roy Vaz, Jinyu Liu, Yi Li, Markus Metz, Anatoly Ruvinsky, Michael Kothe
  • 6-cycloamino-3-(pyrid-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8846676
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: September 30, 2014
    Assignee: Sanofi
    Inventors: Antonio Almario Garcia, Mathieu Barrague, Philippe Burnier, Cecile Enguehard-Gueiffier, Zhongli Gao, Pascal George, Alain Gueiffier, Adrien Tak Li, Frederic Peuch, Roy Vaz, Qiuxia Zhao
  • Substituted propane phosphinic acid derivatives
    Patent number: 8828974
    Abstract: The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.
    Type: Grant
    Filed: April 24, 2012
    Date of Patent: September 9, 2014
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Yong Mi Choi-Sledeski, Julian Levell, Gregory Bernard Poli, Mark Czekaj, Alan John Collis, Roy Vaz
  • 6-cycloamino-3-(pyrid-4-yl)imidazo[1,2-b]pyridazine derivatives, preparation thereof and therapeutic use thereof
    Patent number: 8354405
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: January 15, 2013
    Assignee: Sanofi
    Inventors: Antonio Almario Garcia, Matthieu Barrague, Philippe Burnier, Cécile Enguehard, Zhongli Gao, Pascal George, Alain Gueiffier, Adrien Tak Li, Frédéric Puech, Roy Vaz, Qiuxia Zhao
  • 6-CYCLOAMINO-3-(PYRID-4-YL)IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20130012516
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: SANOFI
    Inventors: Antonio ALMARIO GARCIA, Matthieu BARRAGUE, Philippe BURNIER, Cécile ENGUEHARD, Zhongli GAO, Pascal GEORGE, Alain GUEIFFIER, Adrien Tak LI, Frédéric PUACH, Roy VAZ, Qiuxia ZHAO
  • SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES
    Publication number: 20120208784
    Abstract: The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.
    Type: Application
    Filed: April 24, 2012
    Publication date: August 16, 2012
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Yong Mi CHOI-SLEDESKI, Julian LEVELL, Gregory Bernard POLI, Mark CZEKAJ, Alan John COLLIS, Roy VAZ
  • Substituted propane phosphinic acid derivatives
    Patent number: 8183231
    Abstract: The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: May 22, 2012
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Yong Mi Choi-Sledeski, Julian Levell, Gregory Bernard Poli, Mark Czekaj, Alan John Collis, Roy Vaz
  • 6-CYCLOAMINO-3-(PYRID-4-YL)IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
    Publication number: 20100179154
    Abstract: The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[I,2-b]pyridazine derivatives corresponding to general formula (I): Wherein R2, R3, R7, R8, A, L and B are as defined herein. Also disclosed are the preparative methods and therapeutic use thereof.
    Type: Application
    Filed: December 24, 2009
    Publication date: July 15, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Antonio ALMARIO GARCIA, Matthieu BARRAGUE, Philippe BURNIER, Cécile ENGUEHARD-GUEIFFIER, Zhongli GAO, Pascal GEORGE, Alain GUEIFFIER, Adrien Tak LI, Frédéric PEUCH, Roy VAZ, Qiuxia ZHAO
  • SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES
    Publication number: 20070060502
    Abstract: The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this invention are useful in treating a variety of diseases including but not limited to depression, anxiety, certain psychiatric symptoms, cognitive impairment and schizophrenia.
    Type: Application
    Filed: October 24, 2006
    Publication date: March 15, 2007
    Applicant: AVENTIS PHARMACEUTICALS INC.
    Inventors: Yong Choi-Sledeski, Julian Levell, Gregory Poli, Mark Czekaj, Alan Collis, Roy Vaz
  • Polynucleotide encoding a novel cysteine protease of the calpain superfamily, CAN-12, and variants thereof
    Publication number: 20060183196
    Abstract: The present invention provides novel polynucleotides encoding CAN-12 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants of CAN-12 polypeptides, CAN-12v1 and CAN-12v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel CAN-12, CAN-12v1, and CAN-12v2 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly neuro- and musculo-degenerative conditions. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
    Type: Application
    Filed: April 19, 2006
    Publication date: August 17, 2006
    Inventors: Jian Chen, John Feder, Thomas Nelson, Steven Seiler, Roy Vaz, Franck Duclos