Patents by Inventor Roy W. Ware

Roy W. Ware has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MORPHIC FORMS OF 4-AMINO-7-(3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-2-METHYL-7H-PYRROLO[2,3-d]PYRIMIDINE-5-CARBOXAMIDE AND USES THEREOF
    Publication number: 20220220146
    Abstract: The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.
    Type: Application
    Filed: August 4, 2021
    Publication date: July 14, 2022
    Inventors: Roy W. WARE, Venkat LAKSHMANAN, Aaron Leigh DOWNEY
  • PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF
    Publication number: 20220002335
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: January 27, 2021
    Publication date: January 6, 2022
    Inventors: John Henry BOUGHER, III, Ramamurty V S CHANGALVALA, Aaron Leigh DOWNEY, John C. DRACH, Ernest Randall LANIER, JR., Andrew Louis MCIVER, Bradley David ROBERTSON, Dean Wallace SELLESETH, Phiroze Behram SETHNA, Leroy TOWNSEND, Roy W. WARE
  • Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof
    Patent number: 11111264
    Abstract: The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: September 7, 2021
    Assignee: Chimerix, Inc.
    Inventors: Roy W. Ware, Venkat Lakshmanan, Aaron Leigh Downey
  • Pyrrolopyrimidine nucleosides and analogs thereof
    Patent number: 10941175
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: March 9, 2021
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • MORPHIC FORMS OF 4-AMINO-7-(3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-2-METHYL-7H-PYRROLO[2,3-d]PYRIMIDINE-5-CARBOXAMIDE AND USES THEREOF
    Publication number: 20200277323
    Abstract: The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.
    Type: Application
    Filed: September 21, 2018
    Publication date: September 3, 2020
    Inventors: Roy W. WARE, Venkat LAKSHMANAN, Aaron Leigh DOWNEY
  • PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF
    Publication number: 20200199167
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: August 6, 2019
    Publication date: June 25, 2020
    Inventors: John Henry BOUGHER, III, Ramamurty V S CHANGALVALA, Aaron Leigh DOWNEY, John C. DRACH, Ernest Randall LANIER, Jr., Andrew Louis MCIVER, Bradley David ROBERTSON, Dean Wallace SELLESETH, Phiroze Behram SETHNA, Leroy TOWNSEND, Roy W. WARE
  • Pyrrolopyrimidine nucleosides and analogs thereof
    Patent number: 10407457
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: September 10, 2019
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Nucleoside phosphonate salts
    Patent number: 9765100
    Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: September 19, 2017
    Assignee: Chimerix, Inc.
    Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
  • PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF
    Publication number: 20170253628
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: May 18, 2017
    Publication date: September 7, 2017
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, JR., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Pyrrolopyrimidine nucleosides and analogs thereof
    Patent number: 9708359
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: July 18, 2017
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Pyrrolopyrimidine nucleosides and analogs thereof
    Patent number: 9701706
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: July 11, 2017
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF
    Publication number: 20170137454
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Inventors: Roy W. Ware, Leroy Townsend, John C. Drach
  • PYRROLOPYRIMIDINE NUCLEOSIDES AND ANALOGS THEREOF
    Publication number: 20170044202
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Itc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: August 8, 2016
    Publication date: February 16, 2017
    Inventors: Roy W. Ware, Leroy Townsend, John Drach
  • BRANCHED CHAIN ACYCLIC NUCLEOSIDE PHOSPHONATE ESTERS AND METHODS OF SYNTHESIS AND USES THEREOF
    Publication number: 20170029451
    Abstract: The present invention is directed to branched chain nucleoside phosphonate ester compounds and methods of synthesis thereof. The present invention is also directed to pharmaceutical compositions comprising branched chain nucleoside phosphonate ester compounds and methods of treating and/or preventing double stranded DNA viral infection and/or viral infection associated disease or disorder.
    Type: Application
    Filed: December 5, 2014
    Publication date: February 2, 2017
    Inventors: Roy W. WARE, Aaron L. DOWNEY, Ernest Randall LANIER, Phiroze SETHNA, Dean SELLESETH
  • Phosphonate ester derivatives and methods of synthesis thereof
    Patent number: 9303051
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: April 5, 2016
    Assignee: Chimerix Inc.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • PHOSPHONATE ESTER DERIVATIVES AND METHODS OF SYNTHESIS THEREOF
    Publication number: 20150329575
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Application
    Filed: July 24, 2015
    Publication date: November 19, 2015
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • NUCLEOSIDE PHOSPHONATE SALTS
    Publication number: 20150203519
    Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Application
    Filed: March 30, 2015
    Publication date: July 23, 2015
    Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
  • Nucleoside phosphonate salts
    Patent number: 9006218
    Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: (I), wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: April 14, 2015
    Assignee: Chimerix Inc.
    Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
  • Phosphonate Ester Derivatives and Methods of Synthesis Thereof
    Publication number: 20140046085
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Application
    Filed: October 18, 2013
    Publication date: February 13, 2014
    Applicant: CHIMERIX, INC.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Phosphonate ester derivatives and methods of synthesis thereof
    Patent number: 8569321
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: October 29, 2013
    Assignee: Chimerix, Inc.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert