Patents by Inventor Roy W. Ware

Roy W. Ware has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10407457
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: September 10, 2019
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Patent number: 9765100
    Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: September 19, 2017
    Assignee: Chimerix, Inc.
    Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
  • Publication number: 20170253628
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: May 18, 2017
    Publication date: September 7, 2017
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, JR., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Patent number: 9708359
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: July 18, 2017
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Patent number: 9701706
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: July 11, 2017
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Publication number: 20170137454
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Inventors: Roy W. Ware, Leroy Townsend, John C. Drach
  • Publication number: 20170044202
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Itc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: August 8, 2016
    Publication date: February 16, 2017
    Inventors: Roy W. Ware, Leroy Townsend, John Drach
  • Publication number: 20170029451
    Abstract: The present invention is directed to branched chain nucleoside phosphonate ester compounds and methods of synthesis thereof. The present invention is also directed to pharmaceutical compositions comprising branched chain nucleoside phosphonate ester compounds and methods of treating and/or preventing double stranded DNA viral infection and/or viral infection associated disease or disorder.
    Type: Application
    Filed: December 5, 2014
    Publication date: February 2, 2017
    Inventors: Roy W. WARE, Aaron L. DOWNEY, Ernest Randall LANIER, Phiroze SETHNA, Dean SELLESETH
  • Patent number: 9303051
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Grant
    Filed: July 24, 2015
    Date of Patent: April 5, 2016
    Assignee: Chimerix Inc.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Publication number: 20150329575
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Application
    Filed: July 24, 2015
    Publication date: November 19, 2015
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Publication number: 20150203519
    Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Application
    Filed: March 30, 2015
    Publication date: July 23, 2015
    Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
  • Patent number: 9006218
    Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: (I), wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: April 14, 2015
    Assignee: Chimerix Inc.
    Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
  • Publication number: 20140046085
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Application
    Filed: October 18, 2013
    Publication date: February 13, 2014
    Applicant: CHIMERIX, INC.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Patent number: 8569321
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: October 29, 2013
    Assignee: Chimerix, Inc.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Publication number: 20130035313
    Abstract: The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: (I), wherein M+ is Na+, Li+, K+, Ca2+, Mg2+, or NRcRdReRf+ and Rc, Rd, Re and Rf are each independently hydrogen or C1-5 alkyl, or a stereoisomer, a diastereomer, an enantiomer or racemate thereof.
    Type: Application
    Filed: February 14, 2011
    Publication date: February 7, 2013
    Inventors: Merrick Almond, Bernhard Lampert, Ernest Randall Lanier, Roy W. Ware
  • Publication number: 20120058976
    Abstract: The disclosure describes methods of synthesis of phosphonate ester derivatives. Preferred methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of phosphonate ester derivatives without the use of chromatographic purification methods and in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of phosphonate ester derivatives.
    Type: Application
    Filed: August 31, 2011
    Publication date: March 8, 2012
    Applicant: Chimerix, Inc.
    Inventors: Roy W. Ware, Merrick R. Almond, Bernhard M. Lampert
  • Patent number: 7371852
    Abstract: Alkyl-linked nucleotide non-homogeneous solid supports and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: May 13, 2008
    Assignee: Serenex, Inc.
    Inventors: Klass P. Hardeman, Steven E. Hall, Roy W. Ware, Lindsay A. Hinkley, Matthew G. Jenks
  • Patent number: 7282506
    Abstract: Disclosed are compounds of formula A: and pharmaceutically acceptable salts thereof, wherein R1, R2, R2?, R3, R21, A1, A2, X, and Z are as defined herein. Compounds of formula A are useful in the treatment of diseases and/or conditions related to cell differentiation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
    Type: Grant
    Filed: August 3, 2005
    Date of Patent: October 16, 2007
    Assignee: Serenex, Inc.
    Inventors: Gunnar J. Hanson, Roy W. Ware, Jr., Thomas E. Barta, He Huang
  • Publication number: 20040215009
    Abstract: Alkyl-linked nucleotide compositions and nucleotide affinity media comprising an alkyl-linked nucleotide are provided. The linker is generally a hydrophobic linker that can be a 3, 4, 5, 6, 7, 8, 9, 10, or a longer carbon chain. Also included in the invention are methods for synthesis of an alkyl-linked nucleotide, nucleotide affinity media and methods of use thereof for affinity chromatography and screening methods.
    Type: Application
    Filed: January 21, 2004
    Publication date: October 28, 2004
    Applicant: Serenex, Inc.
    Inventors: Klass P. Hardeman, Steven E. Hall, Roy W. Ware, Lindsay A. Hinkley, Matthew G. Jenks