Abstract: The present subject matter is directed to methods of treating Allan-Herndon-Dudley syndrome comprising administering 3,5-diiodothyropropionic acid (DITPA) to a subject in need thereof, wherein the DITPA administration reduces triiodothyronine (“T3”) serum levels to normal, increases T3 brain levels to normal, and maintains normal serum levels of thyroxine (T4) and thyroid stimulating hormone (TSH). The subject may be a child or an adult.

Abstract: The present subject matter is directed to methods of treating Allan-Herndon-Dudley syndrome comprising administering 3,5-diiodothyropropionic acid (DITPA) to a subject in need thereof, wherein the DITPA administration reduces triiodothyronine (“T3”) serum levels to normal, increases T3 brain levels to normal, and maintains normal serum levels of thyroxine (T4) and thyroid stimulating hormone (TSH). The subject may be a child or an adult.

Abstract: A system for generating processed audio signals may include an earphone comprising a microphone configured to capture sounds from an environment of the earphone, a first communication component, and a first processor; and an earphone case comprising an earphone compartment configured to receive the earphone, a second communication component, and a second processor. The first processor may be programmed to receive a captured audio signal representative of the sounds captured by the microphone; and transmit the captured audio signal via the first communication component. The second processor may be programmed to receive the captured audio signal via the second communication component; generate a processed audio signal based on analysis of the captured audio signal; and transmit the processed audio signal via the second communication component to the first communication component.

Abstract: The present disclosure is directed to methods of treating Allan-Herndon-Dudley syndrome comprising administering 3,5-diiodothyropropionic acid (DITPA) to a pregnant mother of a prenatal subject in need thereof, and to pharmaceutical DIPTA formulations for administration to the pregnant mother of a prenatal subject in need thereof.

Abstract: The present subject matter is directed to methods of treating Allan-Herndon-Dudley syndrome comprising administering 3,5-diiodothyropropionic acid (DITPA) to a subject in need thereof, wherein the DITPA administration reduces triiodothyronine (“T3”) serum levels to normal, increases T3 brain levels to normal, and maintains normal serum levels of thyroxine (T4) and thyroid stimulating hormone (TSH). The subject may be a child or an adult.

Abstract: The present disclosure is directed to methods of treating Allan-Herndon-Dudley syndrome comprising administering 3,5-diiodothyropropionic acid (DITPA) to a subject in need thereof, and to administering gene therapy to the subject by introducing normal human MCT8 into the subject's cells in order to increase T3 in the subject's brain.

Abstract: A system for generating processed audio signals may include an earphone comprising a microphone configured to capture sounds from an environment of the earphone, a first communication component, and a first processor; and an earphone case comprising an earphone compartment configured to receive the earphone, a second communication component, and a second processor. The first processor may be programmed to receive a captured audio signal representative of the sounds captured by the microphone; and transmit the captured audio signal via the first communication component. The second processor may be programmed to receive the captured audio signal via the second communication component; generate a processed audio signal based on analysis of the captured audio signal; and transmit the processed audio signal via the second communication component to the first communication component.