Patents by Inventor Royal A. McGraw

Royal A. McGraw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for automated synthesis of oligonucleotides
    Patent number: 5541314
    Abstract: Apparatus and method for the automated synthesis of DNA segments utilizing multiple reaction columns, all of which are open at the inlet end to the atmosphere of a reaction chamber. A movable reagent supply line outlet is positioned adjacent to the column inlet end to apply reagent to each of the columns according to an input sequence of delivery. The delivery sequence is under processor control. Reagents are removed from all columns simultaneously through the application of vacuum at the outlet end of each column. The device enables the parallel synthesis of large numbers of different oligonucleotide sequences of different lengths.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: July 30, 1996
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Royal A. McGraw, William M. Grosse
  • Automated synthesis of oligonucleotides
    Patent number: 5368823
    Abstract: Apparatus and method for the automated synthesis of DNA segments utilizing multiple reaction columns, all of which are open at the inlet end to the atmosphere of a reaction chamber. A movable reagent supply line outlet is positioned adjacent to the column inlet end to apply reagent to each of the columns according to an input sequence of delivery. The delivery sequence is under processor control. Reagents are removed from all columns simultaneously through the application of vacuum at the outlet end of each column. The device enables the parallel synthesis of large numbers of different oligonucleotide sequences of different lengths.
    Type: Grant
    Filed: February 11, 1993
    Date of Patent: November 29, 1994
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Royal A. McGraw, William M. Grosse
  • Sex-specific DNA probes
    Patent number: 5215884
    Abstract: The present invention are nucleic acid probes which are highly selective for DNA specific to one sex of a livestock species, particularly pigs and chickens, and methods for their isolation, characterization, and utilization. These probes can be applied in a variety of methods for assaying the ratio of male to female mammalian sperm in an isolated fraction or the sex of an egg, as well as for determining the sex of an embryo in the early stages of development.Genomic DNA from whole blood taken from a male and a female animal was digested with various restriction enzymes and the products compared on agarose gels. A band of approximately 4 kilobases in a EcoR1 digest of male pig DNA was absent in female pig DNA. In the chickens, a band of approximately 600 bases and a band of approximately 1200 bases were present in a XhoI digest of female DNA which was not present in the male DNA. The sex-specific DNA was then ligated into a vector and transformed into E. coli.
    Type: Grant
    Filed: July 9, 1991
    Date of Patent: June 1, 1993
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: Royal A. McGraw, III