Abstract: A medical device for ligation or approximating tissue is disclosed. The device has a cannula with proximal and distal ends. The distal end of the cannula has a beveled surface, and the cannula has first and second channels, the first channel extending axially through it, and the second channel extending from the beveled surface to the first channel. The device includes a suture with a slide end and a distal loop, as well as a slip knot securing the loop to the slide end. The slide end is threaded thorough the first and second channels of the cannula and it protrudes from the proximal end of the cannula. In addition, the device incorporates means for securing the positioning of the slide end of the suture in the first channel of the cannula. The device may optionally have a frangible proximal end wherein the proximal end of the suture is mounted to the frangible proximal end.