Patents by Inventor Royden M. Coe

Royden M. Coe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liposome extrusion process
    Patent number: 6623671
    Abstract: A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film by entering the film via the smaller pores and extruded via the larger pores, under pressure, is disclosed. In a preferred embodiment, the porous film is a branched-pore type anodic aluminum oxide porous film. The process produces a population of liposomes substantially free of liposomes above a predetermined maximum size. Also disclosed is an apparatus for carrying out the invention.
    Type: Grant
    Filed: November 20, 2001
    Date of Patent: September 23, 2003
    Inventors: Royden M. Coe, Robert L. Thies, Joel B. Portnoff
  • Liposome extrusion process
    Publication number: 20020050660
    Abstract: A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film under pressure is disclosed. In a preferred embodiment, the porous film is a branched-pore type anodic aluminum oxide porous film. The process produces a population of liposomes substantially free of liposomes above a predetermined maximum size. Also disclosed is an apparatus for carrying out the invention.
    Type: Application
    Filed: November 20, 2001
    Publication date: May 2, 2002
    Inventors: Royden M. Coe, Robert L. Thies, Joel B. Portnoff
  • Formulation preparation device
    Patent number: 5583052
    Abstract: A formulation preparation device is provided herein which contains a valve assembly, transfer spikes, syringe port and tube, these components being interconnected so as to provide for controlled fluid flow between the spikes and port, through the assembly, in specific directions only. The device has an enclosed, sterilizable, gripable housing and can be used to mix combine fluids in reproducible and predetermined proportions. Combination is accomplished aseptically, avoiding contact between the device's operator and the fluids and the substances combined. Biologically active compounds can be combined with one or more fluids, including such aqueous liposome suspensions, using the device. A formulation preparation kit containing, in addition to the device, the fluids and compounds to be formulated is thus also provided herein; methods of using the device to prepare such formulations are further provided herein.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: December 10, 1996
    Assignees: The Liposome Company, Inc., B. Braun Medical, Inc.
    Inventors: Joel B. Portnoff, Royden M. Coe, John Grimm, Kenneth Raines, Joel Bartholomew
  • Method of producing liposomes
    Patent number: 5540936
    Abstract: This invention provides a process for the production of liposomes by combining an organic phase and an aqueous at a volume ratio of less than 3:1; the process can be conducted under conditions which obtain a single-modal population distribution of liposomes encompassing a pre-selected mean particle size. A novel intermediate product obtained during the process, which can itself be used for the topical delivery of a bioactive agent, is also provided.
    Type: Grant
    Filed: June 2, 1994
    Date of Patent: July 30, 1996
    Assignee: The Liposome Company, Inc.
    Inventors: Royden M. Coe, Laura Edgerly-Pflug, Lawrence Boni, Joel Portnoff, Sharma R. Minchey