Patents by Inventor Royston Martin Thomas

Royston Martin Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase
    Patent number: 5736535
    Abstract: The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: April 7, 1998
    Assignee: Zeneca Limited
    Inventors: Peter Robert Bernstein, Philip Duke Edwards, Andrew Shaw, Ashokkumar Bhikkappa Shenvi, Royston Martin Thomas, Chris Allan Veale, Peter Warner, Donald John Wolanin
  • Heterocyclic ketones
    Patent number: 5721222
    Abstract: The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: February 24, 1998
    Assignee: ZENECA Limited
    Inventors: Peter Robert Bernstein, Andrew Shaw, Royston Martin Thomas, Chris Allan Veale, Peter Warner, Donald John Wolanin