Patents by Inventor Ru Bai

Ru Bai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260224592
    Abstract: The invention provides pharmaceutical compositions and methods of use of berberine ursodeoxycholate (BUDC) for treating severe hypertriglyceridemia or an associated diseases or disorder, as monotherapy or in combination therapy with other agents or an adjuvant.
    Type: Application
    Filed: March 1, 2024
    Publication date: August 6, 2026
    Inventors: Liping Liu, Ru Bai, Leigh MacConell
  • Publication number: 20260217699
    Abstract: The invention provides berberine tauroursodeoxycholate (BTUDC), pharmaceutical compositions and methods of use thereof for the treatment, reduction and/or prevention of Parkinson's disease, or an associated disease and disorder, as monotherapy or in combination with other agents or as an adjuvant. The invention further provides pharmaceutical compositions and methods of use of berberine (BBR) and tauroursodeoxycholic acid (TUDCA) for the treatment, reduction and/or prevention of Parkinson's disease, or an associated disease and disorder, as monotherapy or in combination with other agents or as an adjuvant.
    Type: Application
    Filed: February 8, 2024
    Publication date: July 30, 2026
    Inventors: Liping Liu, Ru Bai, Xinxiang Fu, Junwei Cheng, Mingzheng Xie
  • Publication number: 20260116823
    Abstract: A full solid-waste micro-expansive concrete and its preparation method are provided, and relate to the field of concrete material technologies. The full solid-waste micro-expansive concrete includes the following components in parts by weight: 920-1060 parts of a coarse aggregate, 460-582 parts of a fine aggregate, 11-19 parts of an expansive agent, 389-512 parts of a modified solid-waste-based cementitious material, and 231-268 parts of water. The coarse aggregate is coal gangue. The fine aggregate is waste ceramic. The modified solid-waste-based cementitious material includes a solid-waste-based clinker, modified polyvinyl alcohol, and a modified anion exchange resin. The solid-waste-based clinker is prepared from the coal gangue, carbide slag, and desulfurization gypsum. The expansive agent is obtained by calcining the carbide slag.
    Type: Application
    Filed: October 10, 2025
    Publication date: April 30, 2026
    Inventors: Changwang YAN, Rongrong FENG, Ju ZHANG, Ru BAI, Xiaoxiao WANG
  • Publication number: 20250064888
    Abstract: The invention provides compositions and methods for treating, reducing or preventing cytokine storm, for example, in connection with a viral infection (e.g., by SARS-CoV-2), drug treatment or therapy, trauma or an inflammatory disease, or a related disease and disorder.
    Type: Application
    Filed: January 20, 2023
    Publication date: February 27, 2025
    Inventors: Liping Liu, Ru Bai
  • Patent number: 11807672
    Abstract: The invention provides novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and conditions, particularly diseases and conditions relating to diabetes. The compounds of the invention are also useful for treating impaired pancreatic function, treating metabolic diseases, ex vivo islet induction, expansion and proliferation for transplantation, increasing the survival of transplanted islets in vivo, promoting neuroprotection or nerve regeneration, promoting liver regeneration, and inhibiting inflammation.
    Type: Grant
    Filed: October 4, 2020
    Date of Patent: November 7, 2023
    Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.
    Inventors: Liping Liu, Ru Bai
  • Publication number: 20230116498
    Abstract: A concentration method and equipment. The concentration method includes the step of performing reverse osmosis concentration processing on raw milk by using a reverse osmosis membrane. The reverse osmosis concentration processing includes low-pressure reverse osmosis membrane concentration processing and high-pressure reverse osmosis membrane concentration processing, wherein in the low-pressure reverse osmosis membrane concentration processing, reverse osmosis concentration processing is performed on feeding materials by using a first predetermined pressure, and in the high-pressure reverse osmosis membrane concentration processing, the reverse osmosis concentration processing is performed on the feeding materials by using a second predetermined pressure, the first predetermined pressure being lower than the second predetermined pressure. The concentration equipment includes a temporary storage unit, a homogenizing unit, and a particular concentration unit.
    Type: Application
    Filed: March 24, 2020
    Publication date: April 13, 2023
    Applicant: INNER MONGOLIA MENGNIU DAIRY (GROUP) CO., LTD.
    Inventors: Weizhu YU, Jie ZHANG, Mengyuan FAN, Shengbo YU, Yonghong ZHANG, Xinghai LIU, Heqian DONG, Xianfeng REN, Hui WANG, Ru BAI, Hongli SHI, Wenting LIU, Xu WANG
  • Patent number: 11579209
    Abstract: A three-axis magnetic sensor apparatus is described that is processed together into a single chip, with high performance, low cost, as well as small size. The three-axis magnetic sensor apparatus include a substrate, a two-axis magnetic sensing structure and a single-axis sensing structure. The two-axis sensing magnetic structure consisting of two shielded Wheatstone bridge configurations in conjunction with an annular or semi annular magnetic flux-guiding structure, and the single-axis sensing structure consisting of a push-pull Wheatstone bridge in conjunction with a flux guide that is capable of generating a fringe field whose horizontal component is proportional to the vertical component of an external magnetic field. The two-axis magnetic sensing structure and the single-axis structure are processed together into a single chip, and can be used to measure respectively X, Y and Z components of external magnetic fields.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: February 14, 2023
    Inventors: Zhenghong Qian, Ru Bai
  • Patent number: 11534477
    Abstract: This invention discloses certain methods of treating acute pancreatitis and inflammatory pancreatic disease or condition. The disclosed peptides and analogs can significantly lower the elevated blood amylase and lipase levels caused by acute pancreatitis and pancreatic inflammation, reduce the degree of injury observed in pancreatic histopathology caused by pancreatitis, and significantly lower the mortality rate of acute pancreatitis.
    Type: Grant
    Filed: September 3, 2020
    Date of Patent: December 27, 2022
    Assignee: SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.
    Inventors: Liping Liu, Ru Bai
  • Publication number: 20220348618
    Abstract: The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for transplantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.
    Type: Application
    Filed: May 18, 2022
    Publication date: November 3, 2022
    Inventors: Liping LIU, Ru Bai
  • Publication number: 20210356533
    Abstract: A three-axis magnetic sensor apparatus is described that is processed together into a single chip, with high performance, low cost, as well as small size. The three-axis magnetic sensor apparatus include a substrate, a two-axis magnetic sensing structure and a single-axis sensing structure. The two-axis sensing magnetic structure consisting of two shielded Wheatstone bridge configurations in conjunction with an annular or semi annular magnetic flux-guiding structure, and the single-axis sensing structure consisting of a push-pull Wheatstone bridge in conjunction with a flux guide that is capable of generating a fringe field whose horizontal component is proportional to the vertical component of an external magnetic field. The two-axis magnetic sensing structure and the single-axis structure are processed together into a single chip, and can be used to measure respectively X, Y and Z components of external magnetic fields.
    Type: Application
    Filed: October 22, 2018
    Publication date: November 18, 2021
    Inventors: Zhenghong Qian, Ru Bai
  • Publication number: 20210122797
    Abstract: The invention provides novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and conditions, particularly diseases and conditions relating to diabetes. The compounds of the invention are also useful for treating impaired pancreatic function, treating metabolic diseases, ex vivo islet induction, expansion and proliferation for transplantation, increasing the survival of transplanted islets in vivo, promoting neuroprotection or nerve regeneration, promoting liver regeneration, and inhibiting inflammation.
    Type: Application
    Filed: October 4, 2020
    Publication date: April 29, 2021
    Inventors: Liping LIU, Ru BAI
  • Publication number: 20210100871
    Abstract: This invention discloses certain method of use of peptides and their analogs in the treatment of acute pancreatitis. The disclosed peptides and analogs can significantly lower the elevated blood amylase and lipase levels caused by acute pancreatitis, reduce the degree of injury observed in pancreatic histopathology caused by pancreatitis, and significantly lower the mortality rate of acute pancreatitis.
    Type: Application
    Filed: September 3, 2020
    Publication date: April 8, 2021
    Inventors: Liping LIU, Ru BAI
  • Patent number: 10899815
    Abstract: The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for transplantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: January 26, 2021
    Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.
    Inventors: Liping Liu, Ru Bai
  • Patent number: 10829527
    Abstract: The invention provides novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and conditions, particularly diseases and conditions relating to diabetes. The compounds of the invention are also useful for treating impaired pancreatic function, treating metabolic diseases, ex vivo islet induction, expansion and proliferation for transplantation, increasing the survival of transplanted islets in vivo, promoting neuroprotection or nerve regeneration, promoting liver regeneration, and inhibiting inflammation.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: November 10, 2020
    Assignee: Shenzhen HighTide Biopharmaceutical, Ltd.
    Inventors: Liping Liu, Ru Bai
  • Publication number: 20200347106
    Abstract: The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for transplantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.
    Type: Application
    Filed: October 21, 2019
    Publication date: November 5, 2020
    Inventors: Liping LIU, Ru Bai
  • Patent number: 10772929
    Abstract: Method of use of peptides and their analogs in the treatment of acute pancreatitis are described. The disclosed peptides and analogs can significantly lower the elevated blood amylase and lipase levels caused by acute pancreatitis, reduce the degree of injury observed in pancreatic histopathology caused by pancreatitis, and significantly lower the mortality rate of acute pancreatitis.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 15, 2020
    Assignee: SHENZHEN HIGHTIDE BIOPHARMACEUTICAL, LTD.
    Inventors: Liping Liu, Ru Bai
  • Publication number: 20190216883
    Abstract: This invention discloses certain method of use of peptides and their analogs in the treatment of acute pancreatitis. The disclosed peptides and analogs can significantly lower the elevated blood amylase and lipase levels caused by acute pancreatitis, reduce the degree of injury observed in pancreatic histopathology caused by pancreatitis, and significantly lower the mortality rate of acute pancreatitis.
    Type: Application
    Filed: May 11, 2017
    Publication date: July 18, 2019
    Inventors: Liping LIU, Ru BAI
  • Publication number: 20190127429
    Abstract: The invention provides novel compounds, in particular peptide and peptide analogs, which exhibit functionalities useful for treating a variety of diseases and conditions, particularly diseases and conditions relating to diabetes. The compounds of the invention are also useful for treating impaired pancreatic function, treating metabolic diseases, ex vivo islet induction, expansion and proliferation for transplantation, increasing the survival of transplanted islets in vivo, promoting neuroprotection or nerve regeneration, promoting liver regeneration, and inhibiting inflammation.
    Type: Application
    Filed: March 9, 2017
    Publication date: May 2, 2019
    Inventors: Liping LIU, Ru BAI
  • Publication number: 20190023755
    Abstract: The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for transplantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.
    Type: Application
    Filed: May 29, 2018
    Publication date: January 24, 2019
    Inventors: Liping Liu, Ru Bai
  • Publication number: 20180009861
    Abstract: The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for trans plantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.
    Type: Application
    Filed: July 19, 2017
    Publication date: January 11, 2018
    Inventors: Liping Liu, Ru Bai