Abstract: Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.

Abstract: A method is disclosed. The method comprises receiving a matrix representation of a source image to be printed, the matrix representation defining a colorant value for each of a plurality of print addressable locations, wherein the colorant values are representative of amounts of print colorant to be delivered to the print addressable locations during a printing operation. The method may comprise identifying, by processing circuitry, a region in the matrix representation having a first print addressable location and an adjacent second print addressable location, wherein a difference between colorant values of the first print addressable location and the second print addressable location meets or exceeds a defined colorant value threshold.

Abstract: An apparatus for computing is presented that includes an input interface to receive a geological model, the geological model representative of a geological volume. The apparatus further includes a processor implementing a DNN, the processor configured to generate a probabilistic geological model that includes, for each cell, and for a set of facies, a probability of the cell being each of the facies, given the geological model and predetermined conditions, and an output interface. The conditions include: a style image, and hard data for regions of the geological volume. Further, a method includes obtaining a reconstruction of (i) a PCA vector obtained from a geological model, and (ii) a perturbed PCA vector created from the model, computing a set of NN weights for each of the reconstructioned vectors, computing a total loss, based on the respective NN weights, and computing an NN backpropagation based upon the total loss.

Abstract: The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.

Abstract: The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.

Abstract: The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.

Abstract: The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.

Abstract: A gasket for a combustion chamber is provided. The gasket comprises an upper assembly including an upper combustion sealing section with a raised bead positioned between a first component and a second component adjacent to a combustion chamber and an upper fluid sealing section positioned between the first component and the second component at a location spaced away from the combustion chamber. The upper combustion sealing section includes an anti-fret coating on a metal layer, the upper fluid sealing section includes a synthetic rubber coating on a metal layer, and the upper combustion sealing section is greater in thickness than the upper fluid sealing section.

Abstract: Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.

Abstract: The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.

Abstract: A gasket for a combustion chamber is provided. The gasket comprises a plated surface extending across at least a portion of the metal base. In the gasket, at least a portion of the plated surface includes a laser treated section with a first raised surface that protrudes away from the metal base and the laser treated section is arranged in a mid-span that is arranged between two cylinder openings.

Abstract: The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.

Abstract: Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.

Abstract: A physics-informed attention-based neural network (PIANN) system, wherein the PIANN system is a computer system configured to implement a PIANN, the computer system comprising at least one processor and memory storing computer instructions, wherein, when the at least one processor executes the computer instructions, the PIANN system is trained to learn a solution or model for a partial differential equation (PDE) respecting one or more physical constraints, and wherein the PIANN includes a physics-informed neural network (PINN) implementing a deep neural network and a transition zone detector. According to at least some implementations, the PIANN implements a recurrent neural network (RNN).

Abstract: The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.

Abstract: A gasket for a combustion chamber is provided. The gasket comprises a plated surface extending across at least a portion of the metal base. In the gasket, at least a portion of the plated surface includes a laser treated section with a first raised surface that protrudes away from the metal base and the laser treated section is arranged in a mid-span that is arranged between two cylinder openings.

Abstract: A gasket for a combustion chamber is provided. The gasket comprises an upper assembly including an upper combustion sealing section with a raised bead positioned between a first component and a second component adjacent to a combustion chamber and an upper fluid sealing section positioned between the first component and the second component at a location spaced away from the combustion chamber. The upper combustion sealing section includes an anti-fret coating on a metal layer, the upper fluid sealing section includes a synthetic rubber coating on a metal layer, and the upper combustion sealing section is greater in thickness than the upper fluid sealing section.

Abstract: A resource exploitation management system, method and a computer program product therefor. A description of new geological evidence for a geological resource is received, e.g., as one or more triples describing the evidence. Keywords in the description are matched against keywords in representations in a geological resource database. Geological relations are inferred from the descriptions and matched against predefined geological relations from the geological resource database. Consistent triple matches are merged with the geological resource database. The confidence level for merged matches is updated in the geological resource database.

Abstract: One aspect includes a method for determining a drilling plan for new wells in a reservoir. The method includes categorizing the new wells into at least a first new well and a second new well, such that a drilling location for at least the first new well must be determined imminently, but a drilling location for at least the second new well can be determined at a later time. The method further includes determining potential drilling locations for the second new well, determining the drilling location for the first new well based at least in part on the determined potential drilling locations for the second new well, and outputting the drilling plan comprising the determined drilling location for the first new well and the determined potential drilling locations for the second new well.

Abstract: A cryogenic-rated vibration sensor generally includes a cryogenic-rated accelerometer mounted to a top planar surface of an insulation block, wherein the insulation block includes a threaded opening on a bottom planar surface thereof for attachment to an object. Also disclosed are cryogenic pumps including the cryogenic-rated vibration sensor.