Abstract: A method of estimating a probability of live birth in an infertility subject includes: receiving a parameter set including an anti-Mllerian hormone (AMH) value and a follicle-stimulating hormone (FSH) value, the AMH and FSH values generated using one or more samples from the infertility subject; adding a constant to the AMH value and the FSH value to generate an increased AMH value and an increased FSH value; transforming the increased AMH value and the increased FSH value to produce an augmented parameter set including a logarithmic AMH value and a logarithmic FSH value; and solving a generalized additive mixed model for a probability of live birth in the infertility subject based the augmented parameter set, wherein the generalized additive mixed model was previously backfit with a data set of subject data including the augmented parameter set for each infertility subject in the data set.

Abstract: One aspect of the invention provides a method of diagnosing and treating a subject presenting with a pregnancy of unknown location (PUL). The method includes: obtaining a parameter set including: a first ?-human chorionic gonadotropin (?-hCG) value generated using a first sample from a subject; and a second ?-human chorionic gonadotropin (?-hCG) value generated using a second sample from a subject, wherein the second sample is obtained between about 36 hours and about 72 hours after the first sample; providing the parameter set as an input to either a computer-implemented method as described herein or a computer executing the program instructions of a non-transitory computer readable medium as described herein; receiving a probability of ectopic pregnancy in the subject; and treating the subject based on the probability.