Patents by Inventor Ruben Boon

Ruben Boon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for differentiating cells into hepatic stellate cells
    Patent number: 11492596
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other applications, for treatment of liver deficiencies, liver metabolism studies, and liver toxicity studies, fibrogenic studies, or to support hepatocyte function in co-culture setting.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: November 8, 2022
    Assignees: Katholieke Universiteit Leuven, Institut D'Investigacions Biomediques August PI | Sunyer (IDIBAPS)
    Inventors: Catherine Verfaillie, Ruben Boon, Pau Sancho Bru, Mar Col Loperena, Luis Perea Sanchez
  • METHODS FOR DIFFERENTIATING CELLS INTO HEPATIC STELLATE CELLS
    Publication number: 20200248146
    Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other applications, for treatment of liver deficiencies, liver metabolism studies, and liver toxicity studies, fibrogenic studies, or to support hepatocyte function in co-culture setting.
    Type: Application
    Filed: December 1, 2016
    Publication date: August 6, 2020
    Applicants: Katholieke Universiteit Leuven, Institut D'Investigacions Biomediques August PI I Sunyer (IDIBAPS)
    Inventors: Catherine Verfaillie, Ruben Boon, Pau Sancho Bru, Mar Col Loperena, Luis Perea Sanchez
  • CELL CULTURE MEDIA FOR DIFFERENTIATION OF STEM CELLS INTO HEPATOCYTES
    Publication number: 20200199528
    Abstract: The invention relates to methods and media for inducing or maintaining a mature hepatocyte phenotype in a cell, the method comprising the step of cultivation cells in a cell culture medium comprising at least 10 mg amino acids/ml medium, wherein at least 50% (w/w) of the concentration of said amino acids in said medium is provided by one up to five amino acids and, with the proviso that said one up to five amino acids is not one of Thr, Tyr, Cys, Met, Arg and His.
    Type: Application
    Filed: June 15, 2018
    Publication date: June 25, 2020
    Inventors: Ruben Boon, Cathérine Verfaillie