Patents by Inventor Ruben Deogracias

Ruben Deogracias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID CONSTRUCTS FOR DELIVERING POLYNUCLEOTIDES INTO EXOSOMES
    Publication number: 20230287408
    Abstract: The invention delivers exogenous nucleotide sequences into exosomes using structural and regulatory characteristics identified in the miRNA molecules MIR21, pri-miR-21 and pre-miR- 21. In particular, the invention relates to pre-miRNA for targeting an exogenous nucleotide sequence to an exosome, wherein the pre-miRNA comprises an exogenous nucleotide sequence and a stem-loop structure, wherein the stem comprises at least one wobble pair. The invention also provides nucleic acid cassettes, vectors and cells comprising the engineered pre-miRNA, methods of loading exosomes and the resulting loaded exosomes. The loaded exosomes can be used to deliver an exogenous nucleotide sequence to a target cell, for example in therapy.
    Type: Application
    Filed: December 18, 2020
    Publication date: September 14, 2023
    Inventors: Randolph CORTELING, Ruben DEOGRACIAS
  • GENETIC MODIFICATION SITE
    Publication number: 20230227854
    Abstract: This invention relates to genetic engineering, in particular to an insertion site for a transgene, cells comprising a transgene or other modification at that insertion site, vectors for targeting that insertion site, and methods for creating transgenic cells by insertion or other modification at that site. The insertion site, or “safe harbour locus”, is identified within the SPATA13 gene on human chromosome 13q12.12. Mammalian cells comprising a genetic modification within the SPATA13 gene on chromosome 13q12.12 are described, wherein the modification may be an insertion such as an integrated transgene. Nucleic acid molecules able and adapted to guide the insertion of a transgene to that insertion site are also described. These cells or nucleic acids may be useful in therapy.
    Type: Application
    Filed: August 10, 2020
    Publication date: July 20, 2023
    Inventors: Randolph CORTELING, Ruben DEOGRACIAS
  • Use of 1-{4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl}-azetidine-3-carboxylic acid in treating symptoms associated with rett syndrome
    Patent number: 9265754
    Abstract: Use of an S1P receptor modulator in the treatment or prevention of a disease or condition dependent on brain-derived neurotrophic factor (BDNF) expression.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: February 23, 2016
    Assignee: Novartis AG
    Inventors: Yves-Alain Barde, Graeme Bilbe, Ruben Deogracias, Rainer R. Kuhn, Tomoya Matsumoto, Anis Khusro Mir, Anna Svenja Schubart
  • USE OF S1P RECEPTOR MODULATOR
    Publication number: 20140235610
    Abstract: Use of an S1P receptor modulator in the treatment or prevention of a disease or condition dependent on brain-derived neurotrophic factor (BDNF) expression.
    Type: Application
    Filed: December 5, 2013
    Publication date: August 21, 2014
    Inventors: Yves-Alain BARDE, Graeme BILBE, Ruben DEOGRACIAS, Rainer R. KUHN, Tomoya MATSUMOTO, Anis Khusro MIR, Anna Svenja SCHUBART
  • USE OF S1P RECEPTOR MODULATOR
    Publication number: 20140011884
    Abstract: Use of an S1P receptor modulator in the treatment or prevention of a disease or condirion dependent on brain-derived neurotrophic factor (BDNF) expression.
    Type: Application
    Filed: May 13, 2013
    Publication date: January 9, 2014
    Inventors: Yves-Alain BARDE, Graeme BILBE, Ruben DEOGRACIAS, Rainer R, KUHN, Tomoya MATSUMOTO, Anis Khusro MIR, Anna Svenja SCHUBART
  • USE OF S1P RECEPTOR MODULATOR
    Publication number: 20120245129
    Abstract: Use of an S1P receptor modulator in the treatment or prevention of a disease or condirion dependent on brain-derived neurotrophic factor (BDNF) expression.
    Type: Application
    Filed: December 5, 2011
    Publication date: September 27, 2012
    Inventors: Yves-Alain Barde, Graeme Bilbe, Ruben Deogracias, Rainer R. Kuhn, Tomoya Matsumoto, Anis Khusro Mir, Anna Svenja Schubart
  • USE OF S1P RECEPTOR MODULATOR
    Publication number: 20100093672
    Abstract: Use of an S1P receptor modulator in the treatment or prevention of a disease or condition dependent on brain-derived neurotrophic factor (BDNF) expression.
    Type: Application
    Filed: May 1, 2008
    Publication date: April 15, 2010
    Inventors: Yves-Alain Barde, Graeme Bilbe, Ruben Deogracias, Rainer R. Kuhn, Tomoya Matsumoto, Anis K. Mir, Anna S. Schubart