Patents by Inventor Ruben Gerardus Leenders

Ruben Gerardus Leenders has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESSES FOR THE PREPARATION OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]-2-PYRIMIDINYL]AMINO]BENZONITRILE
    Publication number: 20070191407
    Abstract: Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) in the presence of a suitable solvent; b) reacting an intermediate of formula (IV) with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent; c) dehydrating the corresponding amide of the compound of formula (I).
    Type: Application
    Filed: April 23, 2007
    Publication date: August 16, 2007
    Inventors: Didier Schils, Joannes Willems, Bart Petrus Anna Medaer, Elisabeth Therese Pasquier, Paul Janssen, Jan Heeres, Ruben Gerardus Leenders, Jerome Guillemont
  • Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-2pyrimidinyl]amino]benzonitrile
    Publication number: 20060167253
    Abstract: Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) in the presence of a suitable solvent; b) reacting an intermediate of formula (IV) with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent; c) dehydrating the corresponding amide of the compound of formula (I).
    Type: Application
    Filed: August 7, 2003
    Publication date: July 27, 2006
    Inventors: Didier Philippe Schils, Joannes Josephus Willems, Bart Petrus Anna Medaer, Elisabeth Pasquier, Paul Janssen, Jan Heeres, Ruben Gerardus Leenders, Jerome Guillemont