Abstract: An analog-to-digital converter (ADC) includes a first controlled oscillator (CO) for generating at least one phase signal, and wherein the at least one phase signal generates a first output signal of the ADC; and at least one first frequency-controlled resistor (FDR) for receiving the at least one phase signal generated by the first CO, wherein the first CO and the at least one first FDR are coupled together at a first subtraction node of the ADC, and wherein the first subtraction node receives a first input signal.

Abstract: The present disclosure relates to gene therapy vector for use in the treatment of cerebro tendinous xanthomatosis. More specifically, the present invention relates to a nucleic acid construct comprising liver specific promoter operably linked to a nucleic acid sequence encoding for the sterol 27-hydroxylase for the treatment of CTX.

Abstract: The invention relates to nucleic acid constructs and gene therapy vectors that comprise an ATP7B variant for use in the treatment of conditions associated with a deficiency or dysfunction of Copper-transporting ATPase 2, and particularly of Wilson's disease. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases' levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.

Abstract: The invention relates to nucleic acid constructs and gene therapy vectors that comprise an ATP7B variant for use in the treatment of conditions associated with a deficiency or dysfunction of Copper-transporting ATPase 2, and particularly of Wilson's disease. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases' levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.

Abstract: The invention relates to a nucleic acid construct carrying ATP7B protein, an expression vector and a viral particle comprising the nucleic acid construct, and their use for treatment of Wilson's disease and other conditions caused by a deficiency or dysfunction of ATP7B protein. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.

Abstract: The invention relates to a nucleic acid construct carrying ATP7B protein, an expression vector and a viral particle comprising the nucleic acid construct, and their use for treatment of Wilson's disease and other conditions caused by a deficiency or dysfunction of ATP7B protein. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.

Abstract: The invention relates to nucleic acid constructs and gene therapy vectors that comprise an ATP7B variant for use in the treatment of conditions associated with a deficiency or dysfunction of Copper-transporting ATPase 2, and particularly of Wilson's disease. An AAV vector devised according to the invention significantly reduced urine Cu excretion, and liver Cu content in Wilson's disease mice treated with the vector, while ceruloplasmin activity was significantly restored. On the other hand, the administration of the vector resulted in the normalization of serum transaminases' levels and of liver histology, together with a marked reduction of the inflammatory infiltrate.

Abstract: The invention relates to reagents and methods for the generation of auto-inactivating helper adenoviruses that allow the development of cell systems for the generation of high-capacity recombinant adenovirus showing a reduced contamination by auxiliary adenoviruses.

Abstract: The present invention relates to containers, and more particularly to a cereal carton with a closing device, such as a cap. Unlike conventional cereal cartons, the container of the present invention does not include a plastic bag. The upper region of the container includes an angled surface connecting top surface and one of the side surfaces. The angled surface includes an access port with an opening, which is covered by a closing device. The closing device hermitically seals the container to preserve its contents.

Abstract: A transfer switch system includes a normal power supply and an emergency power supply. A set of linked switches select between these power supplies. A breaker seperates the power supplies from loading circuit. The switches and the breaker are mounted within an enclosure having an exterior handle. The exterior handle controls the selection between the normal and emergency power supplies.

Abstract: A transfer switch system includes a normal power supply and an emergency power supply. A set of linked switches select between these power supplies. A breaker seperates the power supplies from loading circuit. The switches and the breaker are mounted within an enclosure having an exterior handle. The exterior handle controls the selection between the normal and emergency power supplies.

Abstract: A method and apparatus for networked in-store media advertising. A local media advertising system is operably coupled to a media content server via a communications network such as the Internet. The local media advertising system receives advertising content and an advertising content display schedule from the content server. The local media advertising system displays the advertising content according to the advertising content display schedule. The local media advertising system has a viewer sensor that the local media advertising system uses to compile viewer data about the number of viewers and customers in the vicinity of the displayed media content. The local media advertising system generates viewer information about how many viewers and customers were in the vicinity of the displayed advertising content using the viewer data and the advertising content display schedule. The local media advertising system then transmits the viewer information to a statistics server via the communications network.

Abstract: A seat track assembly comprises a lower track assembly having a lower track and an upper track assembly slidable over the lower track assembly and having an upper track. An elongate upper bracket and an elongate lower bracket enhance resistance to vertical dislocation. The upper bracket is attached to the upper track and has first and second projections which are positioned on opposite sides of the upper track. The lower bracket is attached to the lower track. The upper bracket can slide free of the lower bracket in a normal operating condition, and the first and second projections of the upper bracket are received by the lower bracket to resist vertical dislocation of the upper track when the upper track assembly is subjected to a vertical dislocation force. The first and second projections are preferably unitary extensions of the upper bracket, and are connected to each other by a connecting segment attached to the upper track.

Abstract: A seat track assembly comprises a lower track assembly comprising first and second lower tracks laterally spaced from and aligned generally parallel with one another. Each lower track has a bottom wall and left and right side walls which cooperate with the bottom wall to define a central channel running the length of the lower track. The left and right side walls each have flanges bent over and away from the central channel. An upper track assembly operatively engages the lower track assembly. The upper track assembly comprises first and second upper tracks carried by corresponding first and second lower tracks, allowing the upper track assembly to slide in forward and rearward directions. An elongate upper J-hook is rigidly attached to each upper track, preferably at a top wall of each upper track. An elongate lower J-hook is rigidly attached to each lower track, preferably at a bottom wall of each track.

Abstract: A rollerless seat track assembly and a motor vehicle seat having a rollerless seat track assembly is shown having a lower track mounted to a base or floor of a motor vehicle, and a slidable upper track attached to a seat base. The upper track has a top wall and a pair of side walls. The lower track has a pair of flanges positioned adjacent a primary load bearing contact surface. Preferably a low friction coating, such as a PTFE epoxy paint is applied to the primary load bearing contact surface of the lower track, and a preferably elongate glide strip or glide member may be affixed to a lower side of the top wall of the upper track. As the seat track slides back and forth, the glide strip would slide over the low friction coating, minimizing the efforts required to adjust the seat. Lateral stability may be enhanced by lateral stabilization ball bearings running in raceways between the upper and lower tracks.

Abstract: A seat track assembly for a motor vehicle is disclosed, comprising: an upper track sub-assembly having an upper track; a lower track sub-assembly having a lower track and a stop, with the upper track being slidable over the lower track; and a positive engagement inertia latch for resisting axial sliding motion of the upper track sub-assembly relative the lower track sub-assembly in response to acceleration of the gear relative the lower track sub-assembly. The inertia latch preferably comprises a gear being movable between a non-latching position wherein the gear is rotatable in response to axial sliding of the upper track sub-assembly and a latching position wherein in response to a sudden change in velocity the gear engages the stop, locking the upper track sub-assembly with the lower track sub-assembly. The gear can be mounted on an axle. A base is affixed to the lower seat track sub-assembly, having a contoured surface which receives the axle.

Abstract: A vehicle seat assembly has first and second fore-and-aft extending lower track sub-assemblies for mounting to a vehicle, typically to the floor pan of the passenger compartment of the vehicle. First and second upper track sub-assemblies are carried by the lower track sub-assemblies. More specifically, the upper track sub-assemblies each include a track slidingly coupled with a corresponding lower track. One or both of the upper track sub-assemblies further includes a structurally robust J-hook which receives a downward flange of the corresponding lower track sub-assembly. The overlapping flange and J-hook arrangement limits vertical dislocation of the upper track sub-assembly, and, therefore, also limits vertical dislocation of the vehicle seat, relative the lower track sub-assembly. In the normal condition, the flange and J-hook arrangement permits free fore-and-aft travel. That is, the sliding tracks can be moved relative each other for adjustment of the fore-and-aft position of the vehicle seat.