Patents by Inventor Ruben Lopez-Vales

Ruben Lopez-Vales has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Maresins for use in the treatment of CNS injuries
    Patent number: 11583511
    Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: February 21, 2023
    Assignees: UNIVERSITAT AUTONOMA DE BARCELONA, OHIO STATE UNIVERSITY, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Ruben Lopez Vales, Isaac Francos Quijorna, Jan Markus Schwab, Samuel David
  • Specialized pro-resolving lipid mediators for use in the treatment of neurodegenerative diseases and/or autoimmune diseases
    Patent number: 11484520
    Abstract: The present invention relates to a specialized pro-resolving lipid mediator comprising maresins, D-series resolvins, E-series resolvins, protectins or lipoxins, or a combination thereof, for use in the treatment of neurodegenerative diseases and/or autoimmune diseases.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: November 1, 2022
    Assignee: UNIVERSITAT AUTONOMA DE BARCELONA
    Inventors: Ruben Lopez Vales, Alba Sanchez Fernandez, Anna Martinez Muriana, Isaac Francos-Quijorna
  • MARESINS FOR USE IN THE TREATMENT OF CNS INJURIES
    Publication number: 20200163923
    Abstract: The present invention relates to maresins, preferably maresin-1, for use in the treatment of CNS injuries preferably selected from spinal cord injury and traumatic brain injury.
    Type: Application
    Filed: July 20, 2017
    Publication date: May 28, 2020
    Applicants: UNIVERSITAT AUTONOMA DE BARCELONA, OHIO STATE UNIVERSITY, MCGILL UNIVERSITY
    Inventors: Ruben LOPEZ VALES, Isaac FRANCOS QUIJORNA, Jan Markus SCHWAB, David SAMUEL
  • SPECIALIZED PRO-RESOLVING LIPID MEDIATORS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES AND/OR AUTOIMMUNE DISEASES
    Publication number: 20200038356
    Abstract: The present invention relates to a specialized pro-resolving lipid mediator comprising maresins, D-series resolvins, E-series resolvins, protectins or lipoxins, or a combination thereof, for use in the treatment of neurodegenerative diseases and/or autoimmune diseases.
    Type: Application
    Filed: January 17, 2018
    Publication date: February 6, 2020
    Applicant: UNIVERSITAT AUTONOMA DE BARCELONA
    Inventors: Ruben LOPEZ VALES, Alba SANCHEZ FERNANDEZ, Anna MARTINEZ MURIANA
  • Treatment of neural diseases or conditions
    Patent number: 9050294
    Abstract: Compounds, methods, uses, compositions, kits and packages for the prevention and/or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and/or analogs, derivatives, prodrugs, precursors thereof, and/or salts thereof, are described.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: June 9, 2015
    Assignee: Royal Institution for the Advancement of Learning/McGill University
    Inventors: Danuta Radzioch, Samuel David, Ruben Lopez-Vales, Thomas Skinner
  • TREATMENT OF NEURAL DISEASES OR CONDITIONS
    Publication number: 20140113973
    Abstract: Compounds, methods, uses, compositions, kits and packages for the prevention and/or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and/or analogs, derivatives, prodrugs, precursors thereof, and/or salts thereof, are described.
    Type: Application
    Filed: December 23, 2013
    Publication date: April 24, 2014
    Applicant: Royal Institution for the Advancement of Learning/McGill University
    Inventors: Danuta Radzioch, Samuel David, Ruben Lopez-Vales, Thomas Skinner
  • Treatment of neural diseases or conditions
    Patent number: 8642658
    Abstract: Compounds, methods, uses, compositions, kits and packages for the prevention and/or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and/or analogs, derivatives, pro-drugs, precursors thereof, and/or salts thereof, are described.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: February 4, 2014
    Assignee: Royal Institution for the Advancement of Learning/McGill University
    Inventors: Danuta Radzioch, Samuel David, Ruben Lopez-Vales, Thomas Skinner
  • Phospholipase A2 inhibitors and their use in treating neurological injury and disease
    Patent number: 8420852
    Abstract: Phospholipase A2 (PLA2) forms are expressed in spinal cord whose inhibition induces a potent antihyperalgesia. PLA2 inhibitor compounds are provided that include a common motif consisting of a 2-oxoamide with a hydrocarbon tail and a four carbon tether. The compounds block Group IVA calcium dependent PLA2 (cPLA2) and/or Group VIA calcium independent PLA2 (iPLA2) and/or Group V secreted PLA2 (sPLA2). Pharmaceutical compositions of compounds having cPLA2 inhibitory activity (but not iPLA2 or sPLA2 inhibitory activity) are useful in treating multiple sclerosis, while compositions of compounds having sPLA2 inhibitory activity (as well as iPLA2 and CPLA2 activity) are useful in treating spinal cord injuries (with related functional recovery).
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: April 16, 2013
    Assignee: The Regents of the University of California
    Inventors: Edward A. Dennis, Daren Stephens, Samuel David, Ruben Lopez-Vales, Athena Kalyvas, George Kokotos, Violetta Constantinou-Kokotou, Efrosini Barbayianni, Victoria Magrioti
  • Phospholipase A2 Inhibitors and their Use in Treating Neurological Injury and Disease
    Publication number: 20110105610
    Abstract: Phospholipase A2 (PLA2) forms are expressed in spinal cord whose inhibition induces a potent antihyperalgesia. PLA2 inhibitor compounds are provided that include a common motif consisting of a 2-oxoamide with a hydrocarbon tail and a four carbon tether. The compounds block Group IVA calcium dependent PLA2 (cPLA2) and/or Group VIA calcium independent PLA2 (iPLA2) and/or Group V secreted PLA2 (sPLA2). Pharmaceutical compositions of compounds having cPLA2 inhibitory activity (but not iPLA2 or sPLA2 inhibitory activity) are useful in treating multiple sclerosis, while compositions of compounds having sPLA2 inhibitory activity (as well as iPLA2 and CPLA2 activity) are useful in treating spinal cord injuries (with related functional recovery).
    Type: Application
    Filed: July 3, 2008
    Publication date: May 5, 2011
    Inventors: Edward A. Dennis, Daren Stephen, Samuel David, Ruben Lopez-Vales, Athena Kalyvas, George Kokotos, Violetta Constantinou-Kokoton, Efrosini Barbayianni, Victoria Magrioti
  • TREATMENT OF NEURAL DISEASES OR CONDITIONS
    Publication number: 20100331417
    Abstract: Compounds, methods, uses, compositions, kits and packages for the prevention and/or treatment of neural injury or a neurodegenerative disease, based on the use of a retinoic acid derivative, such as fenretinide, and/or analogs, derivatives, pro-drugs, precursors thereof, and/or salts thereof, are described.
    Type: Application
    Filed: February 20, 2009
    Publication date: December 30, 2010
    Applicant: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARN
    Inventors: Danuta Radzioch, Samuel David, Ruben Lopez-Vales, Thomas Skinner
  • PERFLUOROKETONE COMPOUNDS AND USES THEREOF
    Publication number: 20100048727
    Abstract: Novel perfluoroketone compounds of formula [I] and [Ia] are described. Also described are uses thereof, such as for inhibition of phospholipase A2 activity. Therapeutic uses thereof are also described, such as for the treatment of neural conditions and/or inflammatory conditions, such as demyelinating (e.g., multiple sclerosis) and neural injury (e.g., spinal cord injury).
    Type: Application
    Filed: April 4, 2008
    Publication date: February 25, 2010
    Inventors: Samuel David, Athena Kalyvas, Ruben Lopez-Vales, George Kokotos, Violetta Constantinou-Kokotou, Constantinos Baskakis, Christoforos G. Kokotos, Edward A. Dennis, Daren Stephens