Abstract: The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.

Abstract: The present disclosure provides methods and compositions for treating patients with diabetes mellitus and/or obesity.

Abstract: The disclosure provides a method of generating non-clustered stem cells. Cluster disruption prior to mesoderm differentiation increases yield and efficiency in hEMP and T cell differentiation. Thus, this method allows the development of improved methods of hEMP and T cell differentiation.

Abstract: The present invention provides methods for isolating and cryopreserving tumor infiltrating lymphocytes (TILs) and producing therapeutic populations of TILs, including methods via use of a kit and a semi-automatic device for aseptic disaggregation, enrichment, and cryopreservation of a resected tumor prior to expansion of the TIL population. The present invention also provides methods for expansion, and/or stabilization of TILs, for instance UTILs, compositions involving the same and methods of treatment involving the same.

Abstract: Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.

Abstract: An apparatus for computing is presented that includes an input interface to receive a geological model, the geological model representative of a geological volume. The apparatus further includes a processor implementing a DNN, the processor configured to generate a probabilistic geological model that includes, for each cell, and for a set of facies, a probability of the cell being each of the facies, given the geological model and predetermined conditions, and an output interface. The conditions include: a style image, and hard data for regions of the geological volume. Further, a method includes obtaining a reconstruction of (i) a PCA vector obtained from a geological model, and (ii) a perturbed PCA vector created from the model, computing a set of NN weights for each of the reconstructioned vectors, computing a total loss, based on the respective NN weights, and computing an NN backpropagation based upon the total loss.

Abstract: The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.

Abstract: The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.

Abstract: The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.

Abstract: The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.

Abstract: A gasket for a combustion chamber is provided. The gasket comprises an upper assembly including an upper combustion sealing section with a raised bead positioned between a first component and a second component adjacent to a combustion chamber and an upper fluid sealing section positioned between the first component and the second component at a location spaced away from the combustion chamber. The upper combustion sealing section includes an anti-fret coating on a metal layer, the upper fluid sealing section includes a synthetic rubber coating on a metal layer, and the upper combustion sealing section is greater in thickness than the upper fluid sealing section.

Abstract: The present invention relates to a chimeric molecule useful in adoptive cell therapy (ACT), and cells comprising the same. The chimeric molecule can act as a modulator of cellular activity enhancing responses when an endogenous T-cell receptor (TCR) is engaged with its cognate antigen. The present invention also provides proteins, nucleic acids encoding the chimeric molecule and therapeutic uses thereof.

Abstract: Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.

Abstract: A gasket for a combustion chamber is provided. The gasket comprises a plated surface extending across at least a portion of the metal base. In the gasket, at least a portion of the plated surface includes a laser treated section with a first raised surface that protrudes away from the metal base and the laser treated section is arranged in a mid-span that is arranged between two cylinder openings.

Abstract: The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.

Abstract: Some embodiments provided herein are chimeric costimulatory antigen receptor (CoStAR), useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. In some embodiments, the CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. In some embodiments, CoStAR and/or fusion proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof are also provided.

Abstract: A physics-informed attention-based neural network (PIANN) system, wherein the PIANN system is a computer system configured to implement a PIANN, the computer system comprising at least one processor and memory storing computer instructions, wherein, when the at least one processor executes the computer instructions, the PIANN system is trained to learn a solution or model for a partial differential equation (PDE) respecting one or more physical constraints, and wherein the PIANN includes a physics-informed neural network (PINN) implementing a deep neural network and a transition zone detector. According to at least some implementations, the PIANN implements a recurrent neural network (RNN).

Abstract: The present invention relates to a chimeric costimulatory antigen receptor (CoStAR) useful in adoptive cell therapy (ACT), and cells comprising the CoStAR. The CoStAR can act as a modulator of cellular activity enhancing responses to defined antigens. The present invention also provides CoStAR proteins, nucleic acids encoding the CoStAR and therapeutic uses thereof.

Abstract: A gasket for a combustion chamber is provided. The gasket comprises a plated surface extending across at least a portion of the metal base. In the gasket, at least a portion of the plated surface includes a laser treated section with a first raised surface that protrudes away from the metal base and the laser treated section is arranged in a mid-span that is arranged between two cylinder openings.

Abstract: A gasket for a combustion chamber is provided. The gasket comprises an upper assembly including an upper combustion sealing section with a raised bead positioned between a first component and a second component adjacent to a combustion chamber and an upper fluid sealing section positioned between the first component and the second component at a location spaced away from the combustion chamber. The upper combustion sealing section includes an anti-fret coating on a metal layer, the upper fluid sealing section includes a synthetic rubber coating on a metal layer, and the upper combustion sealing section is greater in thickness than the upper fluid sealing section.