Patents by Inventor Rubin ZHOU

Rubin ZHOU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRICYCLIC HETEROCYCLE COMPOUNDS AS IAP ANTAGONISTS
    Publication number: 20250179073
    Abstract: The present disclosure relates to compounds that inhibit IAP (preferably cIAP1, cIAP2 or XIAP) protein, pharmaceutical compositions comprising the same and methods of using the IAP protein inhibitors in the treatment of diseases and conditions wherein inhibition of IAP protein provides a benefit.
    Type: Application
    Filed: March 10, 2023
    Publication date: June 5, 2025
    Inventors: Jiantao Hu, Jianyong Chen, Fang Liu, Leilei Zhao, Baolin He, Hao Chen, Xianchan Zha, Rubin Zhou, Jun Zhang, Jiawei Wang, Huifang Shi
  • Preparation method of (5-fluoro-2,3-dihydrobenzofuran-4-yl)methanamine or its salt, and intermediates thereof
    Patent number: 12221427
    Abstract: The present invention provides a preparation method of (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine or a salt thereof, which uses 4-fluoro-3-methylphenol as the starting material, and is carried out through the steps of bromination, O-alkylation, cyclization, bromination, azidation or ammonolysis, and reduction. The reaction route of the present invention has simple synthesis process, convenient operation, high yield, and is environmentally friendly. The prepared (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine can be used as an intermediate in pharmaceuticals and fine chemicals.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: February 11, 2025
    Assignees: Ascentage Pharma (Suzhou) Co., Ltd., Ascentage Pharma Group Corp Limited
    Inventors: Qingquan Wu, Xiuling Wang, Jiawei Wang, Rubin Zhou
  • PREPARATION METHOD OF (5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHANAMINE OR ITS SALT, AND INTERMEDIATES THEREOF
    Publication number: 20220298129
    Abstract: The present invention provides a preparation method of (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine or a salt thereof, which uses 4-fluoro-3-methylphenol as the starting material, and is carried out through the steps of bromination, O-alkylation, cyclization, bromination, azidation or ammonolysis, and reduction. The reaction route of the present invention has simple synthesis process, convenient operation, high yield, and is environmentally friendly. The prepared (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine can be used as an intermediate in pharmaceuticals and fine chemicals.
    Type: Application
    Filed: May 10, 2021
    Publication date: September 22, 2022
    Inventors: Qingquan WU, Xiuling WANG, Jiawei WANG, Rubin ZHOU