Patents by Inventor Ruchi Jain Dey

Ruchi Jain Dey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating cancer using bacteria expressing c-di-AMP
    Patent number: 11590177
    Abstract: The present invention includes the discovery of a strain of Mycobacterium comprising an expression vector encoding a di-adenylate cyclase enzyme. The Mycobacterium is selected from the group consisting of Mycobacterium tuberculosis, Mycobacterium bovis, or a combination thereof and the preferred strain of Mycobacterium is BCG. The preferred expression vector is a mycobacterial expression vector including an hsp60 promoter and a DNA sequence of diadenylate cyclase (disA), or a functional part thereof. The strains of Mycobacterium are used in therapeutic applications including tuberculosis and cancer.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: February 28, 2023
    Assignee: The Johns Hopkins University
    Inventors: William R. Bishai, Ruchi Jain Dey, Bappaditya Dey, Laurene Cheung
  • Methods of Treating Cancer Using Bacteria Expressing c-di-AMP
    Publication number: 20210145896
    Abstract: The present invention includes the discovery of a strain of Mycobacterium comprising an expression vector encoding a di-adenylate cyclase enzyme. The Mycobacterium is selected from the group consisting of Mycobacterium tuberculosis, Mycobacterium bovis, or a combination thereof and the preferred strain of Mycobacterium is BCG. The preferred expression vector is a mycobacterial expression vector including an hsp60 promoter and a DNA sequence of diadenylate cyclase (disA), or a functional part thereof. The strains of Mycobacterium are used in therapeutic applications including tuberculosis and cancer.
    Type: Application
    Filed: November 19, 2020
    Publication date: May 20, 2021
    Inventors: William R. Bishai, Ruchi Jain Dey, Bappaditya Dey, Laurene Cheung
  • Methods of treating cancer using bacteria expressing c-di-AMP
    Patent number: 10842828
    Abstract: Described herein are methods of treating or preventing cancer in a subject comprising administering to the subject an effective amount of a bacteria comprising and expression vector encoding a di-adenylate cyclase enzyme.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: November 24, 2020
    Assignee: The Johns Hopkins University
    Inventors: William R. Bishai, Ruchi Jain Dey, Bappaditya Dey, Laurene Cheung
  • Methods of treating cancer using bacteria expressing c-di-AMP
    Publication number: 20190030091
    Abstract: Described herein are methods of treating or preventing cancer in a subject comprising administering to the subject an effective amount of a bacteria comprising and expression vector encoding a di-adenylate cyclase enzyme.
    Type: Application
    Filed: October 1, 2018
    Publication date: January 31, 2019
    Inventors: William R. Bishai, Ruchi Jain Dey, Bappaditya Dey, Laurene Cheung
  • Bacteria over-expressing c-di-AMP and therapeutic methods
    Patent number: 10130663
    Abstract: The present invention includes the discovery of a strain of Mycobacterium comprising an expression vector encoding a di-adenylate cyclase enzyme. The Mycobacterium is selected from the group consisting of Mycobacterium tuberculosis, Mycobacterium bovis, or a combination thereof and the preferred strain of Mycobacterium is BCG. The preferred expression vector is a mycobacterial expression vector including an hsp60 promoter and a DNA sequence of diadenylate cyclase (disA), or a functional part thereof. The strains of Mycobacterium are used in therapeutic applications including tuberculosis and cancer.
    Type: Grant
    Filed: February 10, 2016
    Date of Patent: November 20, 2018
    Assignee: The John Hopkins University
    Inventors: William R. Bishai, Ruchi Jain Dey, Bappaditya Dey, Laurene Cheung
  • BACTERIA OVER-EXPRESSING C-DI-AMP AND THERAPEUTIC METHODS
    Publication number: 20180028577
    Abstract: The present invention includes the discovery of a strain of Mycobacterium comprising an expression vector encoding a di-adenylate cyclase enzyme. The Mycobacterium is selected from the group consisting of Mycobacterium tuberculosis, Mycobacterium bovis, or a combination thereof and the preferred strain of Mycobacterium is BCG. The preferred expression vector is a mycobacterial expression vector including an hsp60 promoter and a DNA sequence of diadenylate cyclase (disA), or a functional part thereof. The strains of Mycobacterium are used in therapeutic applications including tuberculosis and cancer.
    Type: Application
    Filed: February 10, 2016
    Publication date: February 1, 2018
    Applicant: The John Hopkins University
    Inventors: William R. Bishai, Ruchi Jain Dey, Bappaditya Dey, Laurene Cheung