Patents by Inventor Ruchi Verma

Ruchi Verma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nanoparticle-induced fusogenicity between liposome and endosome membranes for targeted delivery through endosomal escape
    Patent number: 11433026
    Abstract: The disclosure provides compositions and methods of use of formulations effective for the delivery of biologically active molecules and materials, including therapeutic and diagnostic agents, and combinations thereof, to cells, tissues, and living organisms. More particularly, the present invention is related to the incorporation of hydrophobic nanoparticles, such as hydrophobic metal nanoparticles, into the membranes of vesicular delivery vehicles. These hydrophobic nanoparticles enhance the endosomal membrane fusogenicity of the formulations through the promotion of inverted hexagonal phase formation in the lipid bilayers of the vesicular delivery vehicles. As a result, the vesicular delivery vehicles more readily fuse with the endosomal membranes, leading to enhanced endosomal escape of the vesicular delivery vehicle and its contents, thereby facilitating the delivery of the biologically active molecules and materials incorporated within the vesicular delivery vehicles to their sites of action.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: September 6, 2022
    Assignee: University of Rhode Island Board of Trustees
    Inventors: Ashish Sarode, Ruchi Verma, David Worthen, Ruitang Deng
  • Nanoparticle-Induced Fusogenicity between Liposome And Endosome Membranes For Targeted Delivery Through Endosomal Escape
    Publication number: 20190105271
    Abstract: The disclosure provides compositions and methods of use of formulations effective for the delivery of biologically active molecules and materials, including therapeutic and diagnostic agents, and combinations thereof, to cells, tissues, and living organisms. More particularly, the present invention is related to the incorporation of hydrophobic nanoparticles, such as hydrophobic metal nanoparticles, into the membranes of vesicular delivery vehicles. These hydrophobic nanoparticles enhance the endosomal membrane fusogenicity of the formulations through the promotion of inverted hexagonal phase formation in the lipid bilayers of the vesicular delivery vehicles. As a result, the vesicular delivery vehicles more readily fuse with the endosomal membranes, leading to enhanced endosomal escape of the vesicular delivery vehicle and its contents, thereby facilitating the delivery of the biologically active molecules and materials incorporated within the vesicular delivery vehicles to their sites of action.
    Type: Application
    Filed: April 2, 2018
    Publication date: April 11, 2019
    Inventors: Ashish Sarode, Ruchi Verma, David Worthen, Ruitang Deng