Patents by Inventor Rudiger Marquardt

Rudiger Marquardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6593128
    Abstract: The invention relates to a method for culturing ciliates comprising the steps of placing ciliates and medium therefor in a culture flask; providing said culture flask with a stirrer having a magnetic core, wherein said stirrer is suspended in the top part of the culture flask such that the stirrer does not touch the flask bottom, and wherein the motion of said stirrer is driven by means of a magnetic field; and stirring said ciliates in said culture medium.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: July 15, 2003
    Assignee: Nutrinova
    Inventors: Thomas Kiy, RĂ¼diger Marquardt
  • Patent number: 5962275
    Abstract: The invention relates to an improved process for enzymically galactosylating monosaccharides and oligosaccharides, with in-situ regeneration of the nucleotide sugar (or of the nucleoside diphosphate sugar), in the presence of sucrose synthase, .beta.-1-4-galactosyl transferase and uridine diphosphate-glucose 4'-epimerase, (UDP-glucose 4'-epimerase), in which process the uridine diphosphate-glucose 4'-epimerase is reactivated with a ketosugar derivative.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: October 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Brigitte Horsch, Andreas Seiffert-Storiko, Rudiger Marquardt, Astrid Zervosen, Lothar Elling, Maria Regina Kula
  • Patent number: 5962281
    Abstract: L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Johann Then, Klaus Bartsch, Hans-Matthias Deger, Susanne Grabley, Rudiger Marquardt
  • Patent number: 5919669
    Abstract: L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 6, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Johann Then, Klaus Bartsch, Hans-Matthias Deger, Susanne Grabley, Rudiger Marquardt
  • Patent number: 5879903
    Abstract: Selection of Streptomyces viridochromogenes DSM 4112 for resistance to phosphinothricyl-alanyl-alanine (PTT) results in PTT-resistance selectants. The DNA fragment which carries the phosphinothricin(PTC)-resistance gene is obtained from the total DNA of these selectants by cutting with BamHI, cloning of a fragment 4.0 kb in size, and selection for PTT resistance. This gene is suitable for the production of PTC-resistant plants, and as a resistance marker and for the selective N-acetylation of the L-form of racemic PTC.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 9, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Eckhard Strauch, Wolfgang Wohlleben, Walter Arnold, Renate Alijah, Alfred Puhler, Gerhard Wohner, Rudiger Marquardt, Susanne Grabley, Dieter Brauer, Klaus Bartsch
  • Patent number: 5753470
    Abstract: L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: May 19, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Johann Then, Klaus Bartsch, Hans-Matthias Deger, Susanne Grabley, Rudiger Marquardt
  • Patent number: 5728543
    Abstract: A process is described to specifically hydrolyze the amino acid chain of preproinsulin analogs to give the corresponding insulins. The hydrolysis is catalyzed by clostripain and, if necessary, carboxypeptidase B.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: March 17, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Michael Dorschug, Klaus-Peter Koller, Rudiger Marquardt, Johannes Meiwes
  • Patent number: 5637489
    Abstract: Selection of Streptomyces viridochromogenes DSM 4112 for resistance to phosphinothricyl-alanyl-alanine (PTT) results in PTT-resistance selectants. The DNA fragment which carries the phosphinothricin(PTC)-resistance gene is obtained from the total DNA of these selectants by cutting with BamHI, cloning of a fragment 4.0 kb in size, and selection for PTT resistance. This gene is suitable for the production of PTC-resistant plants, and as a resistance marker and for the selective N-acetylation of the L-form of racemic PTC.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 10, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Eckhard Strauch, Wolfgang Wohlleben, Walter Arnold, Renate Alijah, Alfred Puhler, Gerhard Wohner, Rudiger Marquardt, Susanne Grabley, Dieter Brauer, Klaus Bartsch
  • Patent number: 5273894
    Abstract: Selection of Streptomyces viridochromogenes DSM 4112 for resistance to phosphinothricyl-alanyl-alanine (PTT) results in PTT-resistance selectants. The DNA fragment which carries the phosphinothricin(PTC)-resistance gene is obtained from the total DNA of these selectants by cutting with BamHI, cloning of a fragment 4.0 kb in size, and selection for PTT resistance. This gene is suitable for the production of PTC-resistant plants, and as a resistance marker and for the selective N-acetylation of the L-form of racemic PTC.
    Type: Grant
    Filed: November 20, 1991
    Date of Patent: December 28, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Eckhard Strauch, Wolfgang Wohlleben, Walter Arnold, Renate Alijah, Alfred Puhler, Gerhard Wohner, Rudiger Marquardt, Susanne Grabley, Dieter Brauer, Klaus Bartsch
  • Patent number: 5120654
    Abstract: The ilvE gene from the strain E. coli ATCC 11303 is suitable for achieving overproduction of the coded aliphatic transaminase and thus for preparing the branched-chain amino acids leucine, isoleucine and valine from the corresponding keto precursors.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: June 9, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rudiger Marquardt, Johann Then, Hans-Matthias Deger, Gerhard Wohner, Martyn K. Robinson, Evelyn L. K. Doherty
  • Patent number: 5096905
    Abstract: The invention relates to elaiophylin derivatives of the formulae (I), (I'), (III) and (III') ##STR1## in which the C.dbd.C double bonds in the 2,3 and 4,5 position may also be hydrogenated and in which R.sup.1, R.sup.2, R.sup.3, R.sup.4 and X have the meanings indicated. The invention furthermore relates to a process for the preparation of these elaiophylin derivatives, and the use thereof as pharmaceuticals, in particular as anthelmintic pharmaceuticals.
    Type: Grant
    Filed: September 14, 1989
    Date of Patent: March 17, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Kretzschmar, Peter Hammann, Dieter Duwel, Gerhard Wohner, Rudiger Marquardt, Klaus Kuhlein
  • Patent number: 5091314
    Abstract: The isolation of the tyrB gene contained in E. coli ATCC 11303 and its cloning onto a multicopy plasmid results in a 10-fold increase in the L-phenylalanine yield after the transformation of the starting strain with this plasmid.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: February 25, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rudiger Marquardt, Johann Then, Hans-Matthias Deger, Gerhard Wohner, Martyn K. Robinson, Andrew Doherty
  • Patent number: 4965207
    Abstract: Intensely crimson colonies are obtained from Streptomyces coelicolor DSM 3030 by total digestion of the total DNA, cloning into a suitable vector, and transformation of Streptomyces lividans. Re-isolation of the plasmid DNA and cutting with BamHI results in fragments about 3.4 to 9 kb in length, on which is located the gene which determines production of the coloring agent. This gene is suitable as marker, in particular as inactivation marker, in Streptomycetes.
    Type: Grant
    Filed: August 11, 1987
    Date of Patent: October 23, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunter Muth, Wolfgang Wohlleben, Alfred Puhler, Gerhard Wohner, Rudiger Marquardt
  • Patent number: 4963496
    Abstract: Intensely blue-black colonies are obtained from Streptomyces coelicolor DSM 3030 by total digestion of the total DNA, cloning into a suitable vector, and transformation of a streptomycetes recipient strain. Re-isolation of the plasmid DNA and cutting with BamHI results in a 5.5 kb fragment on which the gene for the coloring agent is located. This gene is suitable as marker, in particular as inactivation marker, in Streptomycetes.
    Type: Grant
    Filed: August 11, 1987
    Date of Patent: October 16, 1990
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gunter Muth, Wolfgang Wohlleben, Alfred Puhler, Gerhard Wohner, Rudiger Marquardt