Patents by Inventor Rudolf DE Jong

Rudolf DE Jong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • WEE1 INHIBITORS AND METHODS FOR TREATING CANCER
    Publication number: 20240408097
    Abstract: Disclosed herein is a method of determining subject sensitivity to a WEE1 inhibitor, comprising obtaining or having obtained a biological sample from the subject, and performing or having performed at least one assay on the biological sample to determine if the subject has an altered function of CCNE1. Also disclosed are methods of treating cancer with a WEE1 inhibitor, comprising identifying a subject having (a) the cancer and (b) endogenous or altered function of CCNE1; and administering an effective amount of the WEE1 inhibitor, or a pharmaceutically acceptable salt thereof, to the subject.
    Type: Application
    Filed: December 19, 2023
    Publication date: December 12, 2024
    Inventors: Ahmed Abdi Samatar, Fernando Donate, Petrus Rudolf de Jong, Laure Escoubet, Wen Liu, Philippe Pultar, Dimitrios Voliotis, Kevin Duane Bunker, Peter Qinhua Huang, Jiali Li
  • WEE1 INHIBITOR FOR CANCER
    Publication number: 20240335447
    Abstract: Disclosed herein is a WEE1 compound, or a pharmaceutically acceptable salt thereof, alone or in combination with a KRAS inhibitor, or a pharmaceutically acceptable salt thereof, for treating a disease or condition, such as a colorectal, pancreatic and/or non-small cell lung cancer.
    Type: Application
    Filed: June 14, 2024
    Publication date: October 10, 2024
    Inventors: Fernando Donate, Hooman Izadi, Petrus Rudolf de Jong, Ahmed Abdi Samatar, Kevin Duane Bunker, Peter Qinhua Huang
  • COMBINATION THERAPIES COMPRISING WEE1 INHIBITORS AND DNA DAMAGE RESPONSE (DDR) INHIBITORS
    Publication number: 20240299395
    Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer.
    Type: Application
    Filed: April 26, 2024
    Publication date: September 12, 2024
    Inventors: Fernando Donate, Laure Escoubet, Petrus Rudolf de Jong, Hooman Izadi, Ahmed Abdi Samatar, Brant Clayton Boren, Kevin Duane Bunker, Peter Qinhua Huang
  • WEE1 COMPOUND FOR TREATING UTERINE SEROUS CARCINOMA
    Publication number: 20240197743
    Abstract: Disclosed herein is a method for treating a subject having uterine serous carcinoma with a WEE1 inhibitor, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 8, 2022
    Publication date: June 20, 2024
    Inventors: Philippe Pultar, Dimitrios Voliotis, Marcus Rodrigues Viana, Fernando Donate, Petrus Rudolf de Jong, Ahmed Abdi Samatar, Kevin Duane Bunker, Peter Qinhua Huang
  • Suspension polymerization of vinyl chloride wherein suspension agent is added after the monomer charge
    Patent number: 4525559
    Abstract: Vinyl chloride polymers and copolymers are produced by suspension polymerization in the presence of a small amount of specific ethylene-vinyl acetate copolymers. The catalysts, the ethylene-vinyl acetate copolymer, and the monomer or monomer mixture are added to the polymerization charge before the suspension agent. The resultant polyvinyl chloride is especially suitable for lowering the viscosity of polyvinyl chloride plastisols.
    Type: Grant
    Filed: August 20, 1982
    Date of Patent: June 25, 1985
    Assignee: Chemische Werke Huels AG
    Inventors: Gilbert Sielfeld, Rudolf de Jong
  • Expandable styrene polymers suitable for the production of quickly moldable cellular bodies
    Patent number: 3972843
    Abstract: Expandable styrene polymers suitable for the production of quickly moldable cellular bodies having reacted therein a uniformly distributed high molecular poly-1-butene which forms a discontinuous phase. The poly-1-butene includes mixed polymers of 1-butene, with 1-butene as the predominant amount and the concentration of poly-1-butene is about 0.01 to 2.0 percent by weight based on the weight of the polystyrene.
    Type: Grant
    Filed: March 24, 1975
    Date of Patent: August 3, 1976
    Assignee: Chemische Werke Huls Aktiengesellschaft
    Inventor: Rudolf DE Jong