Patents by Inventor Rudolf Gilmanshin
Rudolf Gilmanshin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11708572Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap, retain or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes. The acoustic field may be generated, for example, in an acoustic angled wave device or in an acoustic fluidized bed.Type: GrantFiled: May 23, 2019Date of Patent: July 25, 2023Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Kedar C. Chitale, Krishna N. Kumar, Walter M. Presz, Jr., Ruan Zhang, Benjamin Ross-Johnsrud, Rudolf Gilmanshin, Natalia Rodionova, Rui Tostoes
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Patent number: 11420136Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes.Type: GrantFiled: October 19, 2017Date of Patent: August 23, 2022Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Rudolf Gilmanshin, Natalia Rodionova, Benjamin Ross-Johnsrud
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Patent number: 11377651Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.Type: GrantFiled: March 8, 2018Date of Patent: July 5, 2022Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Rui Tostoes, Brian Dutra, Rudolf Gilmanshin, Jason Dionne, Walter M. Presz, Jr., Benjamin Ross-Johnsrud, Goutam Ghoshal, Kedar Chitale
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Patent number: 11324873Abstract: Acoustophoretic devices are disclosed. The devices include a flow chamber, an ultrasonic transducer, a reflector, an inlet, a filtrate outlet, a concentrate outlet, and optionally a lipid collection trap. The ultrasonic transducer and reflector create a multi-dimensional acoustic standing wave in the flow chamber that traps and separates red blood cells and/or lipids from blood. Concentrated red blood cells can be recovered via the concentrate outlet, the lipids can be recovered via the lipid collection trap, and the remaining blood can be recovered via the filtrate outlet. Methods for separating blood components (e.g., red blood cells, lipids, platelets, white blood cells) from blood are also disclosed. The red blood cells can undergo washing with a solvent to remove undesired admixtures. Cryoprotectants can be added or removed from the blood.Type: GrantFiled: September 6, 2016Date of Patent: May 10, 2022Assignee: FloDesign Sonics, Inc.Inventors: Rudolf Gilmanshin, Bart Lipkens, Brian Dutra, Daniel Kennedy
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Publication number: 20220040733Abstract: An acoustophoretic device is disclosed. The acoustophoretic device includes an acoustic chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber emanating from a non-planar face of the piezoelectric material. A method for separating a second fluid or a particulate from a host fluid is also disclosed. The method includes flowing the mixture through an acoustophoretic device. A voltage signal is sent to drive the ultrasonic transducer to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.Type: ApplicationFiled: October 14, 2021Publication date: February 10, 2022Inventors: Bart Lipkens, Walter M. Presz, JR., Kedar Chitale, Thomas J. Kennedy, III, Rudolf Gilmanshin, Dane Mealey, Brian Dutra, David Sokolowski
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Patent number: 11179747Abstract: An acoustophoretic device is disclosed. The acoustophoretic device includes an acoustic chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer includes a piezoelectric material driven by a voltage signal to create a multi-dimensional acoustic standing wave in the acoustic chamber emanating from a non-planar face of the piezoelectric material. A method for separating a second fluid or a particulate from a host fluid is also disclosed. The method includes flowing the mixture through an acoustophoretic device. A voltage signal is sent to drive the ultrasonic transducer to create the multi-dimensional acoustic standing wave in the acoustic chamber such that the second fluid or particulate is continuously trapped in the standing wave, and then agglomerates, aggregates, clumps, or coalesces together, and subsequently rises or settles out of the host fluid due to buoyancy or gravity forces, and exits the acoustic chamber.Type: GrantFiled: July 9, 2016Date of Patent: November 23, 2021Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Walter M Presz, Jr., Kedar Chitale, Thomas J Kennedy, III, Rudolf Gilmanshin, Dane Mealey, Brian Dutra, David Sokolowski
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Patent number: 10947493Abstract: Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the cells through an acoustophoretic device having an ultrasonic transducer including a piezoelectric material driven by a drive signal to create a multi-dimensional acoustic standing wave. A drive signal is sent to drive the at least one ultrasonic transducer to create the multi-dimensional acoustic standing wave. A recirculating fluid stream having a tangential flow path is located substantially tangential to the standing wave and separated therefrom by an interface region. A portion of the cells pass through the standing wave, and the beads are held back from the standing wave in the recirculating fluid stream at the interface region. Also disclosed is an acoustophoretic device having a coolant inlet adapted to permit the ingress of a cooling fluid into the device for cooling the transducer.Type: GrantFiled: August 29, 2017Date of Patent: March 16, 2021Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Rudolf Gilmanshin, Louis Masi, Benjamin Ross-Johnsrud, Erik Miller, Walter M. Presz, Jr., Thomas J. Kennedy, III
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Publication number: 20200399583Abstract: Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the cells through an acoustophoretic device having an ultrasonic transducer including a piezoelectric material driven by a drive signal to create a multi-dimensional acoustic standing wave. A drive signal is sent to drive the at least one ultrasonic transducer to create the multi-dimensional acoustic standing wave. A recirculating fluid stream having a tangential flow path is located substantially tangential to the standing wave and separated therefrom by an interface region. A portion of the cells pass through the standing wave, and the beads are held back from the standing wave in the recirculating fluid stream at the interface region. Also disclosed is an acoustophoretic device having a coolant inlet adapted to permit the ingress of a cooling fluid into the device for cooling the transducer.Type: ApplicationFiled: May 28, 2020Publication date: December 24, 2020Inventors: Bart Lipkens, Rudolf Gilmanshin, Louis Masi, Benjamin Ross-Johnsrud, Erik Miller, Walter M. Presz, JR., Thomas J. Kennedy, III
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Patent number: 10640760Abstract: Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.Type: GrantFiled: May 3, 2017Date of Patent: May 5, 2020Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Walter M. Presz, Jr., Brian Dutra, Rudolf Gilmanshin, Jason Dionne, Chris Leidel, Louis Masi, Goutam Ghoshal, Kedar Chitale
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Publication number: 20190345477Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap, retain or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes. The acoustic field may be generated, for example, in an acoustic angled wave device or in an acoustic fluidized bed.Type: ApplicationFiled: May 23, 2019Publication date: November 14, 2019Inventors: Bart Lipkens, Kedar C. Chitale, Krishna N. Kumar, Walter M. Presz, JR., Ruan Zhang, Benjamin Ross-Johnsrud, Rudolf Gilmanshin, Natalia Rodionova, Rui Tostoes
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Publication number: 20190276815Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.Type: ApplicationFiled: March 8, 2018Publication date: September 12, 2019Inventors: Bart Lipkens, Rui Tostoes, Brian Dutra, Rudolf Gilmanshin, Jason Dionne, Walter M. Presz, JR., Benjamin Ross-Johnsrud, Goutam Ghoshal, Kedar Chitale
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Patent number: 10370635Abstract: Acoustophoretic devices and methods for separating biological cells (particularly T-cells) from other fluids/materials using multi-dimensional acoustic standing waves are disclosed. The devices include an inlet, at least two outlets, and a flow chamber having an ultrasonic transducer-reflector pair. Specifically, T cells, B cells, or NK cells can be separated from other blood components. A dual-pass acoustophoretic system including two acoustophoretic devices arranged in series and fluidly connected to one another is also illustrated. Means for pre-chilling the mixture prior to separation in the devices or system can be used to improve retention, concentration, and clarification and to prevent outgassing.Type: GrantFiled: January 26, 2017Date of Patent: August 6, 2019Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Rudolf Gilmanshin, Brian Dutra, Benjamin Ross-Johnsrud
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Patent number: 10161926Abstract: Devices and methods for inspecting, detecting, isolating, monitoring, characterizing, or separating pathogens in blood containing blood cells are disclosed. The devices include a flow chamber having a solvent inlet, at least one host-fluid inlet, a particulate outlet, at least one residual outlet, and a reflector. The methods include trapping the pathogens in the acoustic standing wave, introducing a solvent into the flow chamber, and removing the pathogens from the device. Devices and methods for inspecting, detecting, isolating, monitoring, characterizing, or separating specialized circulating cells in blood containing blood cells are also disclosed. The devices include a flow chamber having at least one inlet and at least one outlet, and a microscope objective and a cover glass. The methods include driving the transducer to create an acoustic standing wave in the flow chamber and microbubbles in the blood.Type: GrantFiled: June 11, 2016Date of Patent: December 25, 2018Assignee: FloDesign Sonics, Inc.Inventors: Rudolf Gilmanshin, Bart Lipkens
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Publication number: 20180362918Abstract: A closed and modular fluidic system composed of one or more acoustic elements and cell processing reagents. The system employs a cellular manufacturing process for producing cell and gene therapy therapeutics.Type: ApplicationFiled: June 15, 2018Publication date: December 20, 2018Inventors: Bart Lipkens, Rui Tostoes, Brian Dutra, Rudolf Gilmanshin, Jason Dionne, Walter M. Presz, JR., Benjamin Ross-Johnsrud, Goutam Ghoshal, Kedar Chitale
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Publication number: 20180104620Abstract: Beads with functionalized material applied to them are exposed to an acoustic field to trap or pass the beads. The beads may include or be free of ferro magnetic material. The beads may be biocompatible or biodegradable for a host. The size of the beads may vary over a range, and/or be heterogenous or homogenous. The composition of the beads may include high, neutral or low acoustic contrast material. The chemistry of the functionalized material may be compatible with existing processes.Type: ApplicationFiled: October 19, 2017Publication date: April 19, 2018Inventors: Bart Lipkens, Rudolf Gilmanshin, Natalia Rodionova, Benjamin Ross-Johnsrud
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Publication number: 20180066224Abstract: Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the cells through an acoustophoretic device having an ultrasonic transducer including a piezoelectric material driven by a drive signal to create a multi-dimensional acoustic standing wave. A drive signal is sent to drive the at least one ultrasonic transducer to create the multi-dimensional acoustic standing wave. A recirculating fluid stream having a tangential flow path is located substantially tangential to the standing wave and separated therefrom by an interface region. A portion of the cells pass through the standing wave, and the beads are held back from the standing wave in the recirculating fluid stream at the interface region. Also disclosed is an acoustophoretic device having a coolant inlet adapted to permit the ingress of a cooling fluid into the device for cooling the transducer.Type: ApplicationFiled: August 29, 2017Publication date: March 8, 2018Inventors: Bart Lipkens, Rudolf Gilmanshin, Louis Masi, Benjamin Ross-Johnsrud, Erik Miller, Walter M. Presz, JR., Thomas J. Kennedy, III
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Publication number: 20170321208Abstract: Multi-stage acoustophoretic devices for continuously separating a second fluid or a particulate from a host fluid are disclosed. Methods of operating the multi-stage acoustophoretic devices are also disclosed. The systems may include multiple acoustophoretic devices fluidly connected to one another in series, each acoustophoretic device comprising a flow chamber, an ultrasonic transducer capable of creating a multi-dimensional acoustic standing wave, and a reflector. The systems can further include pumps and flowmeters.Type: ApplicationFiled: May 3, 2017Publication date: November 9, 2017Inventors: Bart Lipkens, Walter M. Presz, JR., Brian Dutra, Rudolf Gilmanshin, Jason Dionne, Chris Leidel, Louis Masi, Goutam Ghoshal
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Publication number: 20170260493Abstract: Methods, systems, and apparatus for acoustic separation of cellular supporting materials such as microcarriers or microbubbles from cell culture are provided.Type: ApplicationFiled: May 26, 2017Publication date: September 14, 2017Inventors: Bart Lipkens, Rudolf Gilmanshin, Ben Ross-Johnsrud, Kedar Chitale
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Patent number: 9745548Abstract: Methods are disclosed for separating beads and cells from a host fluid. The method includes flowing a mixture containing the host fluid, the beads, and the cells through an acoustophoretic device having an ultrasonic transducer including a piezoelectric material driven by a drive signal to create a multi-dimensional acoustic standing wave. A drive signal is sent to drive the at least one ultrasonic transducer to create the multi-dimensional acoustic standing wave. A recirculating fluid stream having a tangential flow path is located substantially tangential to the standing wave and separated therefrom by an interface region. A portion of the cells pass through the standing wave, and the beads are held back from the standing wave in the recirculating fluid stream at the interface region. Also disclosed is an acoustophoretic device having a coolant inlet adapted to permit the ingress of a cooling fluid into the device for cooling the transducer.Type: GrantFiled: January 30, 2017Date of Patent: August 29, 2017Assignee: FloDesign Sonics, Inc.Inventors: Bart Lipkens, Rudolf Gilmanshin, Louis Masi, Benjamin Ross-Johnsrud, Erik Miller, Walter M. Presz, Jr., Thomas J. Kennedy, III
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Publication number: 20170218323Abstract: Acoustophoretic devices and methods for separating biological cells (particularly T-cells) from other fluids/materials using multi-dimensional acoustic standing waves are disclosed. The devices include an inlet, at least two outlets, and a flow chamber having an ultrasonic transducer-reflector pair. Specifically, T cells, B cells, or NK cells can be separated from other blood components. A dual-pass acoustophoretic system including two acoustophoretic devices arranged in series and fluidly connected to one another is also illustrated. Means for pre-chilling the mixture prior to separation in the devices or system can be used to improve retention, concentration, and clarification and to prevent outgassing.Type: ApplicationFiled: January 26, 2017Publication date: August 3, 2017Inventors: Bart Lipkens, Rudolf Gilmanshin, Brian Dutra, Benjamin Ross-Johnsrud