Patents by Inventor Rudolf Hulspas
Rudolf Hulspas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200072731Abstract: A flow cell for particle processing such as particle sorting, may be operatively engaged to a particle processing apparatus. The fluid contact surfaces of the flow cell may be fully enclosed. Further, the flow cell may encapsulate all fluid contact surfaces in the particle processing apparatus. The enclosing or encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The flow cell may employ any suitable technique for processing particles. The flow cell may be disposable and suitable for use in droplet sorting. The flow cell may include an operatively sealed sort chamber having a particle stream focusing region, an orifice, an interrogation zone and a sorting region.Type: ApplicationFiled: August 7, 2019Publication date: March 5, 2020Inventors: Johnathan Charles Sharpe, Rudolf Hulspas, Kristopher Scott Buchanan
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Patent number: 10379029Abstract: A flow cell for particle processing such as particle sorting, may be operatively engaged to a particle processing apparatus. The fluid contact surfaces of the flow cell may be fully enclosed. Further, the flow cell may encapsulate all fluid contact surfaces in the particle processing apparatus. The enclosing or encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The flow cell may employ any suitable technique for processing particles. The flow cell may be disposable and suitable for use in droplet sorting. The flow cell may include an operatively sealed sort chamber having a particle stream focusing region, an orifice, an interrogation zone and a sorting region.Type: GrantFiled: September 18, 2013Date of Patent: August 13, 2019Assignee: CYTONOME/ST, LLCInventors: Johnathan Charles Sharpe, Rudolf Hulspas, Kristopher Scott Buchanan
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Patent number: 10274414Abstract: Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard.Type: GrantFiled: May 19, 2014Date of Patent: April 30, 2019Assignee: CYTONOME/ST, LLCInventors: Johnathan Charles Sharpe, Emanuel Tito Mendes Machado, Rudolf Hulspas
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Patent number: 10197493Abstract: A microfluidic multiple channel particle analysis system which allows particles from a plurality of particle sources to be independently simultaneously entrained in a corresponding plurality of fluid streams for analysis and sorting into particle subpopulations based upon one or more particle characteristics.Type: GrantFiled: April 10, 2017Date of Patent: February 5, 2019Assignee: CYTONOME/ST, LLCInventors: Johnathan Charles Sharpe, Emanuel Tito Mendes Machado, Blair D. Morad, Rudolf Hulspas, Donald Francis Perrault, Jr.
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Publication number: 20170343467Abstract: A microfluidic multiple channel particle analysis system which allows particles from a plurality of particle sources to be independently simultaneously entrained in a corresponding plurality of fluid streams for analysis and sorting into particle subpopulations based upon one or more particle characteristics.Type: ApplicationFiled: April 10, 2017Publication date: November 30, 2017Inventors: Johnathan Charles Sharpe, Emanuel Tito Mendes Machado, Blair D. Morad, Rudolf Hulspas, Donald Francis Perrault, JR.
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Patent number: 9618442Abstract: A microfluidic multiple channel particle analysis system which allows particles from a plurality of particle sources to be independently simultaneously entrained in a corresponding plurality of fluid streams for analysis and sorting into particle subpopulations based upon one or more particle characteristics.Type: GrantFiled: June 15, 2015Date of Patent: April 11, 2017Assignee: CYTONOME/ST, LLCInventors: Johnathan Charles Sharpe, Emanuel Tito Mendes Machado, Blair D. Morad, Rudolf Hulspas, Donald Francis Perrault, Jr.
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Publication number: 20150276576Abstract: A microfluidic multiple channel particle analysis system which allows particles from a plurality of particle sources to be independently simultaneously entrained in a corresponding plurality of fluid streams for analysis and sorting into particle subpopulations based upon one or more particle characteristics.Type: ApplicationFiled: June 15, 2015Publication date: October 1, 2015Inventors: Johnathan Charles Sharpe, Emanuel Tito Mendes Machado, Blair D. Morad, Rudolf Hulspas, Donald Francis Perrault, JR.
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Patent number: 9057676Abstract: A microfluidic multiple channel particle analysis system (1) which allows particles (2) from a plurality of particle sources (3) to be independently simultaneously entrained in a corresponding plurality of fluid streams (4) for analysis and sorting into particle subpopulations (5) based upon one or more particle characteristics (6).Type: GrantFiled: February 4, 2011Date of Patent: June 16, 2015Assignee: CYTONOME/ST, LLCInventors: Johnathan Charles Sharpe, Emanuel Tito Mendes Machado, Blair Morad, Rudolf Hulspas, Donald Francis Perrault, Jr.
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Publication number: 20140343869Abstract: Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard.Type: ApplicationFiled: May 19, 2014Publication date: November 20, 2014Applicant: CYTONOME/ST, LLCInventors: Johnathan Charles Sharpe, Emanuel Tito Mendes Machado, Rudolf Hulspas
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Publication number: 20140170697Abstract: A flow cell for particle processing such as particle sorting, may be operatively engaged to a particle processing apparatus. The fluid contact surfaces of the flow cell may be fully enclosed. Further, the flow cell may encapsulate all fluid contact surfaces in the particle processing apparatus. The enclosing or encapsulation of the fluid contact surfaces insures, improves or promotes operator isolation and/or product isolation. The flow cell may employ any suitable technique for processing particles. The flow cell may be disposable and suitable for use in droplet sorting. The flow cell may include an operatively sealed sort chamber having a particle stream focusing region, an orifice, an interrogation zone and a sorting region.Type: ApplicationFiled: September 18, 2013Publication date: June 19, 2014Applicant: CYTONOME/ST, LLCInventors: Johnathan Charles Sharpe, Rudolf Hulspas, Kristopher Scott Buchanan
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Patent number: 8731860Abstract: Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard.Type: GrantFiled: February 7, 2011Date of Patent: May 20, 2014Assignee: Cytonome/ST, LLCInventors: Johnathan Charles, Emanuel Tito Mendes Machado, Rudolf Hulspas
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Publication number: 20120307244Abstract: A microfluidic multiple channel particle analysis system (1) which allows particles (2) from a plurality of particle sources (3) to be independently simultaneously entrained in a corresponding plurality of fluid streams (4) for analysis and sorting into particle subpopulations (5) based upon one or more particle characteristics (6).Type: ApplicationFiled: February 4, 2011Publication date: December 6, 2012Applicant: Cytonome/ST, LLCInventors: Johnathan Charles Sharpe, Emanuel Tito Mendes Machado, Blair Morad, Rudolf Hulspas, Donald Francis Perrault, JR.
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Publication number: 20110196637Abstract: Systems, methods and non-transitory storage medium are disclosed herein for adjusting an output of a particle inspection system representative of a particle characteristic for a particle flowing in a flow-path of a particle processing system. More particularly, the output may be processed and a calibrated output of the particle characteristic generated. In other embodiments, one or more calibration particles are used. Thus, an output of a particle inspection system representative of a particle characteristic for one or more calibration particles flowing in a flow-path of a particle processing system may be compared relative to a standard and an action may be taken based on a result of the comparing the output to the standard.Type: ApplicationFiled: February 7, 2011Publication date: August 11, 2011Applicant: CYTONOME/ST, LLCInventors: Johnathan C. Sharpe, Emanuel Tito Mendes Machado, Rudolf Hulspas