Patents by Inventor Rudolf Hurnaus

Rudolf Hurnaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
    Patent number: 7538115
    Abstract: The present invention relates to substituted piperidines of general formula wherein R, R2 to R5, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: May 26, 2009
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rudolf Hurnaus, Klaus Rudolf, Stephan Georg Mueller, Dirk Stenkamp, Philipp Lustenberger, Alexander Dreyer, Kai Gerlach, Marcus Schindler, Kirsten Arndt, Eckhart Bauer
  • Substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
    Patent number: 7026312
    Abstract: The present invention relates to substituted piperidines of general formula wherein R, R2 to R5, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Grant
    Filed: March 13, 2003
    Date of Patent: April 11, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rudolf Hurnaus, Klaus Rudolf, Stephan Georg Mueller, Dirk Stenkamp, Philipp Lustenberger, Alexander Dreyer, Kai Gerlach, Marcus Schindler, Kirsten Arndt, Eckhart Bauer
  • Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
    Publication number: 20050215546
    Abstract: The present invention relates to substituted piperidines of general formula wherein R, R2 to R5, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.
    Type: Application
    Filed: May 26, 2005
    Publication date: September 29, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rudolf Hurnaus, Klaus Rudolf, Stephan Mueller, Dirk Stenkamp, Phillipp Lustenberger, Alexander Dreyer, Kai Gerlach, Marcus Schindler, Kirsten Arndt, Eckhart Bauer
  • Substituted piperidines, medicaments containing these compounds, and methods for the production thereof
    Patent number: 6949541
    Abstract: The present invention relates to substituted piperidines of general formula wherein A1, A2, R, R1 and R2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: September 27, 2005
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Klaus Rudolf, Henri Doods, Eckhart Bauer, Rudolf Hurnaus, Wolfgang Eberlein, Alexander Dreyer, Stephan Georg Mueller
  • Substituted imidazoles, their preparation and use
    Patent number: 6908926
    Abstract: Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial. These imidazoles compounds have the formula I wherein R1, R2, R3, R4, R5, R6, A, X, Y and Z are as defined in the specification.
    Type: Grant
    Filed: April 12, 2000
    Date of Patent: June 21, 2005
    Assignee: Novo Nordisk A/S
    Inventors: Florencio Zaragoza Dörwald, Knud Erik Andersen, Tine Krogh Jørgensen, Bernd Peschke, Birgitte Schjellerup Wulff, Ingrid Pettersson, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Müller, Bernd Krist
  • Carboxylic acids and the esters thereof, pharmaceutical compositions thereto and processes for the preparation thereof
    Publication number: 20040192729
    Abstract: The present invention relates to carboxylic acids and esters of general formula 1
    Type: Application
    Filed: January 12, 2004
    Publication date: September 30, 2004
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Klaus Rudolf, Stephan Georg Mueller, Marcus Schindler, Dirk Stenkamp, Eckhart Bauer, Kai Gerlach, Rudolf Hurnaus
  • Carbazole derivatives for the treatment of NPY related diseases
    Publication number: 20040147752
    Abstract: The invention relates to novel carbazole derivatives, their use for the preparation of a pharmaceutical composition for the treatment of eating and metabolic disorders such as obesity, bulimia nervosa, anorexia nervosa, of sleep disturbance, of morphine withdrawal symptoms and of epileptic seizures, a pharmaceutical composition containing them and a process for preparing them.
    Type: Application
    Filed: January 8, 2004
    Publication date: July 29, 2004
    Applicants: Boehringer Ingelheim International GmbH, Novo Nordisk A/S
    Inventors: Klaus Rudolf, Rudolf Hurnaus, Wolfgang Eberlein, Wolfhard Engel, Heike-Andrea Wieland, Bernd Krist
  • Substituted imidazoles
    Publication number: 20040127718
    Abstract: The present invention relates to novel substituted imidazoles, to the use of these compounds as medicaments, to pharmaceutical compositions comprising the compounds, and to a method of treatment employing these compounds and compositions. The present compounds show a high and selective binding affinity to the histamine H3 receptor indicating a histamine H3 receptor antagonistic or agonistic activity. As a result, the compounds are useful for the treatment of disorders related to the histamine H3 receptor. More particularly, the present compounds possess a histamine H3 receptor agonistic activity and are accordingly useful in the treatment of disorders in which a histamine H3 receptor activation is beneficial.
    Type: Application
    Filed: December 19, 2003
    Publication date: July 1, 2004
    Applicant: Novo Nordisk A/S
    Inventors: Klaus Rudolf, Rudolf Hurnaus, Dirk Stenkamp, Stephan Mueller, Bernd Krist
  • Imidazole compounds
    Patent number: 6756384
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: June 29, 2004
    Assignees: Novo Nordisk A/S, Boehringer Ingelheim International GmbH
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald, Bernd Peschke, Ulla Grove Sidelmann, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Muller, Bernd Krist, Birgitte Eriksen
  • Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof
    Publication number: 20030236282
    Abstract: The present invention relates to substituted piperidines of general formula 1
    Type: Application
    Filed: March 13, 2003
    Publication date: December 25, 2003
    Applicant: Boehringer ingelheim Pharma GmbH & Co.
    Inventors: Rudolf Hurnaus, Klaus Rudolf, Stephan Georg Mueller, Dirk Stenkamp, Philipp Lustenberger, Alexander Dreyer, Kai Gerlach, Marcus Schindler, Kirsten Arndt, Eckhart Bauer
  • Substituted piperidines, medicaments containing these compounds, and methods for the production thereof
    Publication number: 20030212057
    Abstract: The present invention relates to substituted piperidines of general formula 1
    Type: Application
    Filed: November 7, 2002
    Publication date: November 13, 2003
    Inventors: Klaus Rudolf, Henri Doods, Eckhart Bauer, Rudolf Hurnaus, Wolfgang Eberlein, Alexander Dreyer, Stephan Georg Mueller
  • Substituted imidazoles
    Publication number: 20030181479
    Abstract: The present invention relates to novel substituted imidazoles, to the use of these compounds as medicaments, to pharmaceutical compositions comprising the compounds, and to a method of treatment employing these compounds and compositions. The present compounds show a high and selective binding affinity to the histamine H3 receptor indicating a histamine H3 receptor antagonistic or agonistic activity. As a result, the compounds are useful for the treatment of disorders related to the histamine H3 receptor. More particularly, the present compounds possess a histamine H3 receptor agonistic activity and are accordingly useful in the treatment of disorders in which a histamine H3 receptor activation is beneficial.
    Type: Application
    Filed: November 8, 2002
    Publication date: September 25, 2003
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Klaus Rudolf, Rudolf Hurnaus, Dirk Stenkamp, Stephan Mueller, Bernd Krist
  • Imidazole compounds
    Publication number: 20030135056
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Application
    Filed: July 23, 2002
    Publication date: July 17, 2003
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald, Bernd Peschke, Ulla Grove Sidelmann, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Muller, Bernd Krist, Birgitte Eriksen
  • Imidazole compounds
    Patent number: 6437147
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: August 20, 2002
    Assignees: Novo Nordisk, Boehringer Ingelheim International GmbH
    Inventors: Knud Erik Andersen, Florencio Zaragoza Dorwald, Bernd Peschke, Ulla Grove Sidelmann, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Muller, Bernd Krist, Birgitte Eriksen
  • Imidazole compounds
    Publication number: 20020058659
    Abstract: A novel class of imidazo heterocyclic compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
    Type: Application
    Filed: March 16, 2001
    Publication date: May 16, 2002
    Inventors: Knud Erik Andersen, Florencio Zaragiza Dorwald, Bernd Peschke, Ulla Grove Sidelmann, Klaus Rudolf, Dirk Stenkamp, Rudolf Hurnaus, Stephan Georg Muller, Bernd Krist, Birgitte Eriksen
  • NEW URETHANES, THIO AND DITHIO ANALOGUES AND THEIR USE AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS
    Publication number: 20020019536
    Abstract: The present invention relates to urethanes and the thio and dithio analogues thereof of general formula 1
    Type: Application
    Filed: March 24, 1999
    Publication date: February 14, 2002
    Inventors: ROLAND MAIER, RUDOLF HURNAUS, MICHAEL MARK, BERNHARD EISELE, PETER MUELLER, GEBHARD ADELGOSS, GEBHARD SCHILCHER
  • Urethanes, thio and dithio analogues and their use as inhibitors of cholesterol biosynthesis
    Patent number: 6346545
    Abstract: The present invention relates to urethanes and the thio and dithio analogues thereof of general formula wherein m, n, A, X, Y and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: February 12, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Roland Maier, Rudolf Hurnaus, Michael Mark, Bernhard Eisele, Peter Mueller, Gebhard Adelgoss, Gebhard Schilcher
  • Urethanes derived from azacycloalkanes, the thio and dithio analogues thereof and their use as cholesterol biosynthesis inhibitors
    Patent number: 6339096
    Abstract: The present invention relates to urethanes derived from azacycloalkanes and the thio and dithio analogues thereof of general formula wherein m, n, A, X, Y, E and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, particularly the physiologically acceptable acid addition salts thereof which have valuable properties, particularly an inhibitory effect on cholesterol biosynthesis, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: March 24, 1999
    Date of Patent: January 15, 2002
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Roland Maier, Rudolf Hurnaus, Michael Mark, Bernhard Eisele, Peter Mueller, Gebhard Schilcher, Gebhard Adelgoss
  • Phenylacetic acid benzylamides
    Patent number: 6143769
    Abstract: The present application relates to the uses of phenylacetic acid benzylamides and new (S)(+)-2-ethoxy-4-[N-[1-2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbon ylmethyl]-benzoic acid and the salts thereof, which have valuable pharmacological properties, namely an effect on the intermediate metabolism, but particularly the effect of lowering blood sugar.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: November 7, 2000
    Assignee: Karl Thomae GmbH
    Inventors: Wolfgang Grell, Rudolf Hurnaus, Gerhart Griss, deceased, Robert Sauter, Manfred Reiffen, Eckhard Rupprecht
  • Phenylacetic acid benzylamides
    Patent number: RE37035
    Abstract: Phenylacetic acid benzylamides having the following general structure wherein the substituents are defined herein, are disclosed, which compounds are hypoglcemic agents.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: January 30, 2001
    Assignee: Boehringer Ingelheim KG
    Inventors: Wolfgang Grell, Rudolf Hurnaus, Gerhart Griss, Robert Sauter, Manfred Reiffen, Eckhard Rupprecht