Patents by Inventor Rudolf K. A. Giger

Rudolf K. A. Giger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazolylmethyl-pyridines
    Patent number: 5635521
    Abstract: Compounds of formula I, ##STR1## wherein R.sub.1 to R.sub.4 possess the significances given in the description, may be used in the treatment of senile dementia, Alzheimer's disease and depression.
    Type: Grant
    Filed: April 13, 1995
    Date of Patent: June 3, 1997
    Assignee: Sandoz Ltd.
    Inventor: Rudolf K. A. Giger
  • Use of certain imidazol carbazols in treating stress-related manic-depressive disorders
    Patent number: 5561149
    Abstract: Use of a mono or bicyclic carbocyclic, or heterocyclic carboxylic, acid ester or amide or an imidazolyl carbazol in the manufaccure of a medicament suitable for the treatment of stress-related psychiatric disorders, for increasing vigilance, for the treatment of rhinitis or serotonin-induced disorders and/or coadministration with another active agent to increase the bioavailability thereof, or for nasal administration.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: October 1, 1996
    Assignee: Sandoz Ltd.
    Inventors: Moise Azria, Karl-Heinz Buchheit, Keith A. Dixon, G unther Engel, Rudolf K. A. Giger
  • Use of certain 3,7-disubstituted indole compounds for treating depression or cognitive disorders
    Patent number: 5543426
    Abstract: 3,7-disubstituted indole derivatives of formula I ##STR1## wherein R.sub.1, R.sub.2, n, X, Y and Z are as defined in the description, are useful for the treatment of psychiatric disorders.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: August 6, 1996
    Assignee: Sandoz Ltd.
    Inventors: Arnold K. Dixon, Rudolf K. A. Giger
  • Certain aminoguanidine compounds, pharmaceutical compositions containing them and their use in treating gastrointestinal motility disorders and disorders associated with cephalic pain
    Patent number: 5510353
    Abstract: Compounds of formulaA--X--Y--NH--Bwherein A is derived from optionally substituted benzothiophene, indole, 4-aza-and 7-aza-benzothiophene or-indole, A bearing in position 5 hydrogen, halogen, optionally substituted alkyl, hydroxy, nitro, amino, alkylamino, acylamino, alkoxycarbonyl, sulfamoyl, cyano, trimethylsilyl, carboxy, carbamoyl, phosphate, oxycarbamoyl, heterocyclic radical or ether or ester group, X-Y is --CR.sub.8 .dbd.N-- or CH(R.sub.8)--NH-- wherein R.sub.8 is -H or alkyl and attached at position 3 of A, and B is a heterocyclic radical or a residue ##STR1## wherein R.sub.10 is H, optionally substituted alkyl, cycloalkyl, aryl, adamantyl, acyl or carbamoyl and X.sub.2 is alkylthio or NR.sub.3 R.sub.10 wherein R.sub.3 is H or alkyl or R.sub.3 and R.sub.10 together with the nitrogen atom to which they are attached form a heterocyclic radical, in free form or in salt form, have pharmacological activity, e.g. for treating gastrointestinal disorders.
    Type: Grant
    Filed: January 9, 1995
    Date of Patent: April 23, 1996
    Assignee: Sandoz Ltd.
    Inventors: Rudolf K. A. Giger, Henri Mattes
  • 3,7 substituted indole and indazole compounds and pharmaceutical compositions containing them
    Patent number: 5272154
    Abstract: 3,7-disubstituted indole derivatives of formula I ##STR1## wherein R.sub.1, R.sub.2, n, X, Y and Z are as defined in the description are useful for the treatment of psychiatric disorders.
    Type: Grant
    Filed: December 18, 1991
    Date of Patent: December 21, 1993
    Assignee: Sandoz Ltd.
    Inventors: Arnold K. Dixon, Rudolf K. A. Giger
  • Benzoic acid derivatives
    Patent number: 5001133
    Abstract: The substituted benzoic acid heterocyclic amides and esters are serotonin M antagonists. Included are compounds of the formula Iq ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, Z' and R.sub.8 ' have various definitions.
    Type: Grant
    Filed: November 4, 1988
    Date of Patent: March 19, 1991
    Assignee: Sandoz Ltd.
    Inventors: Brian P. Richardson, Gunter Engel, Rudolf K. A. Giger, Andrea Vasella
  • Analgesic carbocyclic and heterocyclic carbonylmethylene-and carbonylmethypipidines and-pyrrolidines
    Patent number: 4826838
    Abstract: Carbocyclic and heterocyclic carbonylmethylene- and carbonylmethylpiperidines and -pyrrolidines are serotonin antagonists.
    Type: Grant
    Filed: July 7, 1987
    Date of Patent: May 2, 1989
    Assignee: Sandoz Ltd.
    Inventors: Brian P. Richardson, Rudolf K. A. Giger, Gunter Engel, Roland Furler
  • Amides and esters containing bridged piperidines and use as serotonin M antagonists
    Patent number: 4797406
    Abstract: The dicarboxylic, heterocyclic and substituted benzoic acid alkylene bridged piperidyl amides and esters are serotonin M antagonists.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: January 10, 1989
    Assignee: Sandoz Ltd.
    Inventors: Brian P. Richardson, Gunter Engel, Rudolf K. A. Giger, Andrea Vasella
  • Trifluoromethyl substituted tetracyclic quinazolin-ones having tranquilizing activity
    Patent number: 4760065
    Abstract: Trifluoromethyl substituted tetracyclic compounds including optical isomers thereof having the formula: ##STR1## wherein n is 1 or 2 and p is 0 or 1, are useful as CNS agents with tranquilizing effects.
    Type: Grant
    Filed: February 13, 1986
    Date of Patent: July 26, 1988
    Inventors: Goetz E. Hardtmann, William J. Houlihan, Rudolf K. A. Giger
  • Ergotalkaloids for treating senile dementia
    Patent number: 4737499
    Abstract: An ergot 5'S-(2R-butyl) peptide alkaloid and its acid addition salts is a useful pharmaceutical for use as a prolactin secretion inhibitor, for increasing vigilance or for the treatment of senile dementia, hypertension, or stroke.
    Type: Grant
    Filed: November 18, 1986
    Date of Patent: April 12, 1988
    Assignee: Sandoz Ltd.
    Inventor: Rudolf K. A. Giger
  • Naphthoxazines and their use as psychostimulating and antidepressant agents
    Patent number: 4656167
    Abstract: 3,4,4a,5,10,10a-hexahydro-2H-naphth[2,3-b]-1,4-oxazines are useful as psychostimulating and antidepressant agents.
    Type: Grant
    Filed: April 11, 1986
    Date of Patent: April 7, 1987
    Assignee: Sandoz Ltd.
    Inventors: Joachim Nozulak, Rudolf K. A. Giger
  • Dibenz[cd,f]indole derivatives, their preparation and pharmaceutical compositions containing them
    Patent number: 4602032
    Abstract: A 2-alkyl-9,10-dioxy-4,5,5a,6-tetrahydro-dibenz[cd,f]indole or an acid addition salt thereof is a useful anti-parkinson agent.
    Type: Grant
    Filed: December 19, 1984
    Date of Patent: July 22, 1986
    Assignee: Sandoz Ltd.
    Inventor: Rudolf K. A. Giger