Patents by Inventor Rudolf Kotva

Rudolf Kotva has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkyl cyanomethyl ergoline-I derivatives and salts thereof, and methods for their preparation
    Patent number: 4321380
    Abstract: A procedure is described for the preparation of a novel group of alkyl cyanomethyl ergoline-I derivatives and pharmaceutically acceptable salts thereof. The compounds are D-6-alkyl-8-cyanomethylergoline-I derivatives of the formula ##STR1## wherein R is an alkyl group of 2-4 carbon atoms.
    Type: Grant
    Filed: December 13, 1976
    Date of Patent: March 23, 1982
    Assignee: SPOFA, United Pharmaceutical Works
    Inventors: Antonin Cerny, Miroslav Semonsky, Rudolf Kotva, Karel Rezabek, Marie Auskova, Miroslav Seda
  • Derivatives of carboxyalkyl imino- and thioxo-barbituric acids
    Patent number: 4237270
    Abstract: 5-Carboxyalkyl-2-iminobarbituric and 5-carboxyalkyl-2-thioxobarbituric acids and derivatives thereof are prepared either by condensation of a triester of a tricarboxylic acid with a thio or imino diamide to yield an ester which is saponified, the desired compound being obtained by liberation with a mineral acid from an ammoniacal medium containing the saponified ester. Alternatively, free tricarboxylic acids may be substituted for the triesters. The compounds described herein have evidenced a therapeutic effect in animals having transplanted tumors, and have inhibited tumor growth and lengthened the life of animals and humans.
    Type: Grant
    Filed: April 20, 1978
    Date of Patent: December 2, 1980
    Assignee: SPOFA, United Pharmaceutical Works
    Inventors: Miroslav Semonsky, Rudolf Kotva, Antonin Cerny, Jiri Krepelka, Vojtech Pujman, Oskar Andrysek, Hana Vesela, deceased