Patents by Inventor Rudolf Krumbholz
Rudolf Krumbholz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220204915Abstract: The invention relates to the use of microjet reactor for processing biomass. The cell lysis of flowable biomass is thereby carried out by means of multiple high-speed liquid jets which collide with one another, wherein the liquid jets contain the cells or consist wholly of the flowable cell mass, wherein intact or wholly or partially lysed biomass is added to at least one of the colliding high-speed liquid jets, and an extraction takes place simultaneously with the collision of the liquid jets or subsequently thereto. The lysis of the cells is initiated or facilitated by the forces that occur on acceleration, introduction of the acceleration, collision of the jets and mixing of the jet constituents.Type: ApplicationFiled: May 13, 2020Publication date: June 30, 2022Applicant: Mybiotech GmbHInventors: Bernd BAUMSTUEMMLER, Akif Emre TUERELI, Felix PENTH, Daniel MUELLER, Rudolf KRUMBHOLZ
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Patent number: 10273431Abstract: A process for obtaining free fatty acid and/or free fatty acid ester, including separating a liquid mixture containing the free fatty acid and/or the fatty acid ester by contacting a vapor of the liquid mixture in a column of a distillation apparatus with condensate formed from the vapor running downward. Heat and mass transfer takes place between the vapor and the condensate on column internals. The column has at least 10 theoretical plates and the separation is conducted with a pressure drop between the top and bottom of the column of ?p of ?3.3 mbars. Appropriately, the liquid mixture, contains polyunsaturated fatty acid, preferably omega-6 or omega-3 fatty acid and/or alkyl monoesters and/or glycerol monoesters. In one embodiment the column has at least 30 theoretical plates and the separation is conducted with a pressure drop ?p between 3.5 mbar and 6 mbar.Type: GrantFiled: July 6, 2015Date of Patent: April 30, 2019Assignee: K.D. PHARMA BEXBACH GMBHInventor: Rudolf Krumbholz
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Publication number: 20180195020Abstract: A process for obtaining free fatty acid and/or free fatty acid ester, including separating a liquid mixture containing the free fatty acid and/or the fatty acid ester by contacting a vapor of the liquid mixture in a column of a distillation apparatus with condensate formed from the vapor running downward. Heat and mass transfer takes place between the vapor and the condensate on column internals. The column has at least 10 theoretical plates and the separation is conducted with a pressure drop between the top and bottom of the column of ?p of ?3.3 mbars. Appropriately, the liquid mixture, contains polyunsaturated fatty acid, preferably omega-6 or omega-3 fatty acid and/or alkyl monoesters and/or glycerol monoesters. In one embodiment the column has at least 30 theoretical plates and the separation is conducted with a pressure drop ?p between 3.5 mbar and 6 mbar.Type: ApplicationFiled: July 6, 2015Publication date: July 12, 2018Inventor: Rudolf KRUMBHOLZ
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Patent number: 8293932Abstract: A process for extracting a substance or a substance group from a mixture utilizes a solvent for separation. The mixture is treated with the solvent in the presence of a sorbent as the stationary phase, wherein the solvent is conducted past the sorbent in a co-current flow with the mixture or in a counter-current flow against the mixture, or wherein the solvent is conducted past the non-moving mixture and the sorbent. The solvent and the sorbent are selected such that the holding effect of the sorbent supports the separation by the solvent during the separation procedure and/or subsequently supplements the separation by interacting with the solvent as the mobile phase.Type: GrantFiled: June 30, 2006Date of Patent: October 23, 2012Assignee: K.D. Pharma GmbHInventors: Rudolf Krumbholz, Peter Lembke
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Patent number: 8063235Abstract: Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and “reversed phase” phases, the former in turn chosen from the group consisting of RP18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure anType: GrantFiled: June 19, 2007Date of Patent: November 22, 2011Assignee: K.D. Pharma Bexbach GmbHInventors: Rudolf Krumbholz, Peter Lembke, Norbert Schirra
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Publication number: 20110033595Abstract: The present invention relates to a concentration- and purification method for compositions containing phytanic acid and/or derivatives thereof besides other fatty acids and/or their derivatives, preferably besides polyunsaturated fatty acids and/or their derivatives, such as esters or salts. With the fractionation process the phytanic acid (derivative) can become concentrated and the fatty acid mixture, preferably PUFA-mixture, can be purified from this particular component.Type: ApplicationFiled: August 10, 2009Publication date: February 10, 2011Inventors: Rudolf Krumbholz, Peter Lembke
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Publication number: 20110015418Abstract: Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and “reversed phase” phases, the former in turn chosen from the group consisting of RP 18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure aType: ApplicationFiled: June 19, 2007Publication date: January 20, 2011Applicant: K.D. PHARMA BEXBACH GmbHInventors: Rudolf Krumbholz, Peter Lembke, Norbert Schirra
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Publication number: 20100331415Abstract: The invention relates to the use of omega-3-fatty acid(s) in means for pain relief. The means preferably comprise highly unsaturated omega-3-fatty acid(s) that contain, above all, EPA and/or DHA. Preferably, the omega-3-fatty acid is administered in a high dose of more than 2 g, in particular more than 3 to 4 g, for pain relief.Type: ApplicationFiled: November 18, 2008Publication date: December 30, 2010Applicant: K. D. PHARMA BEXBACH GMBHInventors: Rudolf Krumbholz, Karin Krumbholz, Christine Krumbholz, Norbert Schirra, Peter Lembke
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Publication number: 20060247455Abstract: A process for extracting a substance or a substance group from a mixture utilizes a solvent for separation. The mixture is treated with the solvent in the presence of a sorbent as the stationary phase, wherein the solvent is conducted past the sorbent in a co-current flow with the mixture or in a counter-current flow against the mixture, or wherein the solvent is conducted past the non-moving mixture and the sorbent. The solvent and the sorbent are selected such that the holding effect of the sorbent supports the separation by the solvent during the separation procedure and/or subsequently supplements the separation by interacting with the solvent as the mobile phase.Type: ApplicationFiled: June 30, 2006Publication date: November 2, 2006Inventors: Rudolf Krumbholz, Peter Lembke
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Patent number: 6234464Abstract: A microencapsulated unsaturated fatty acid or fatty acid compound or mixture of fatty acids and/or fatty acid compounds, and particularly an omega-3-fatty acid or omega-6-fatty acid or an ethyl ester or a glyceride thereof or a mixture of such fatty acids and/or fatty acid compounds. Fatty acid compounds are understood to include derivatives. Particles of the compounds are provided with capsule walls composed of two layers. The inner layer is composed of gelatin A, gelatine B. casein or an alginate, or of a derivative or salt of one of these polymers. The outer layer is composed of gelatin B, gum arabic, pectin or chitosan or a derivative or salt of one of these polymers.Type: GrantFiled: July 7, 1999Date of Patent: May 22, 2001Assignee: K.D. Pharma Bexbech GmbHInventors: Rudolf Krumbholz, Alf Lamprecht, Claus-Michael Lehr, Ulrich Schäfer, Norbert Schirra, Manfred Treitz
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Patent number: 6042840Abstract: A urea-containing component of a skin care agent or skin preparation, wherein the urea forms inclusion compounds with fatty acids and/or fatty acid compounds, so that fat is made available for skin care which is protected against oxidation. A method of manufacturing the urea-containing component of a skin care agent includes cooking an oil or a mixture of fatty acid ethyl esters manufactured from an oil with urea in a solvent in a non-oxidizing atmosphere until the urea has been dissolved, permitting the mixture to cool, and finally cooling the mixture to a final temperature of below 10.degree. C. and separating the resulting precipitate.Type: GrantFiled: March 16, 1998Date of Patent: March 28, 2000Assignee: K. D. Pharma GmbHInventors: Rudolf Krumbholz, Peter Lembke
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Patent number: 5362895Abstract: A method for recovering at least one unsaturated fatty acid having sixteen or more carbon atoms and/or at least one compound of such a fatty acid from a mixture derived from vegetable, animal or marine sources is provided. Fatty acids and/or fatty acid compounds of the mixture, in free acid or esterified form, are passed into a mobile phase of liquid carbon dioxide in a column over a stationary phase. The stationary phase contains a support and a material bound to the support which contains at least one free electron pair and/or multiple bond. After eluting any saturated fatty acid or fatty acid compound of the same number of carbon atoms from the column, the unsaturated fatty acid and/or fatty acid compound is recovered in pure chemical form or as an enriched mixture.Type: GrantFiled: March 1, 1993Date of Patent: November 8, 1994Assignee: K.D. Pharma GmbHInventors: Heinz Engelhardt, Rudolf Krumbholz, Peter Lembke