Patents by Inventor Rudolf Krumbholz

Rudolf Krumbholz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220204915
    Abstract: The invention relates to the use of microjet reactor for processing biomass. The cell lysis of flowable biomass is thereby carried out by means of multiple high-speed liquid jets which collide with one another, wherein the liquid jets contain the cells or consist wholly of the flowable cell mass, wherein intact or wholly or partially lysed biomass is added to at least one of the colliding high-speed liquid jets, and an extraction takes place simultaneously with the collision of the liquid jets or subsequently thereto. The lysis of the cells is initiated or facilitated by the forces that occur on acceleration, introduction of the acceleration, collision of the jets and mixing of the jet constituents.
    Type: Application
    Filed: May 13, 2020
    Publication date: June 30, 2022
    Applicant: Mybiotech GmbH
    Inventors: Bernd BAUMSTUEMMLER, Akif Emre TUERELI, Felix PENTH, Daniel MUELLER, Rudolf KRUMBHOLZ
  • Patent number: 10273431
    Abstract: A process for obtaining free fatty acid and/or free fatty acid ester, including separating a liquid mixture containing the free fatty acid and/or the fatty acid ester by contacting a vapor of the liquid mixture in a column of a distillation apparatus with condensate formed from the vapor running downward. Heat and mass transfer takes place between the vapor and the condensate on column internals. The column has at least 10 theoretical plates and the separation is conducted with a pressure drop between the top and bottom of the column of ?p of ?3.3 mbars. Appropriately, the liquid mixture, contains polyunsaturated fatty acid, preferably omega-6 or omega-3 fatty acid and/or alkyl monoesters and/or glycerol monoesters. In one embodiment the column has at least 30 theoretical plates and the separation is conducted with a pressure drop ?p between 3.5 mbar and 6 mbar.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: April 30, 2019
    Assignee: K.D. PHARMA BEXBACH GMBH
    Inventor: Rudolf Krumbholz
  • Publication number: 20180195020
    Abstract: A process for obtaining free fatty acid and/or free fatty acid ester, including separating a liquid mixture containing the free fatty acid and/or the fatty acid ester by contacting a vapor of the liquid mixture in a column of a distillation apparatus with condensate formed from the vapor running downward. Heat and mass transfer takes place between the vapor and the condensate on column internals. The column has at least 10 theoretical plates and the separation is conducted with a pressure drop between the top and bottom of the column of ?p of ?3.3 mbars. Appropriately, the liquid mixture, contains polyunsaturated fatty acid, preferably omega-6 or omega-3 fatty acid and/or alkyl monoesters and/or glycerol monoesters. In one embodiment the column has at least 30 theoretical plates and the separation is conducted with a pressure drop ?p between 3.5 mbar and 6 mbar.
    Type: Application
    Filed: July 6, 2015
    Publication date: July 12, 2018
    Inventor: Rudolf KRUMBHOLZ
  • Patent number: 8293932
    Abstract: A process for extracting a substance or a substance group from a mixture utilizes a solvent for separation. The mixture is treated with the solvent in the presence of a sorbent as the stationary phase, wherein the solvent is conducted past the sorbent in a co-current flow with the mixture or in a counter-current flow against the mixture, or wherein the solvent is conducted past the non-moving mixture and the sorbent. The solvent and the sorbent are selected such that the holding effect of the sorbent supports the separation by the solvent during the separation procedure and/or subsequently supplements the separation by interacting with the solvent as the mobile phase.
    Type: Grant
    Filed: June 30, 2006
    Date of Patent: October 23, 2012
    Assignee: K.D. Pharma GmbH
    Inventors: Rudolf Krumbholz, Peter Lembke
  • Patent number: 8063235
    Abstract: Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and “reversed phase” phases, the former in turn chosen from the group consisting of RP18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure an
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: November 22, 2011
    Assignee: K.D. Pharma Bexbach GmbH
    Inventors: Rudolf Krumbholz, Peter Lembke, Norbert Schirra
  • Publication number: 20110033595
    Abstract: The present invention relates to a concentration- and purification method for compositions containing phytanic acid and/or derivatives thereof besides other fatty acids and/or their derivatives, preferably besides polyunsaturated fatty acids and/or their derivatives, such as esters or salts. With the fractionation process the phytanic acid (derivative) can become concentrated and the fatty acid mixture, preferably PUFA-mixture, can be purified from this particular component.
    Type: Application
    Filed: August 10, 2009
    Publication date: February 10, 2011
    Inventors: Rudolf Krumbholz, Peter Lembke
  • Publication number: 20110015418
    Abstract: Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and “reversed phase” phases, the former in turn chosen from the group consisting of RP 18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure a
    Type: Application
    Filed: June 19, 2007
    Publication date: January 20, 2011
    Applicant: K.D. PHARMA BEXBACH GmbH
    Inventors: Rudolf Krumbholz, Peter Lembke, Norbert Schirra
  • Publication number: 20100331415
    Abstract: The invention relates to the use of omega-3-fatty acid(s) in means for pain relief. The means preferably comprise highly unsaturated omega-3-fatty acid(s) that contain, above all, EPA and/or DHA. Preferably, the omega-3-fatty acid is administered in a high dose of more than 2 g, in particular more than 3 to 4 g, for pain relief.
    Type: Application
    Filed: November 18, 2008
    Publication date: December 30, 2010
    Applicant: K. D. PHARMA BEXBACH GMBH
    Inventors: Rudolf Krumbholz, Karin Krumbholz, Christine Krumbholz, Norbert Schirra, Peter Lembke
  • Publication number: 20060247455
    Abstract: A process for extracting a substance or a substance group from a mixture utilizes a solvent for separation. The mixture is treated with the solvent in the presence of a sorbent as the stationary phase, wherein the solvent is conducted past the sorbent in a co-current flow with the mixture or in a counter-current flow against the mixture, or wherein the solvent is conducted past the non-moving mixture and the sorbent. The solvent and the sorbent are selected such that the holding effect of the sorbent supports the separation by the solvent during the separation procedure and/or subsequently supplements the separation by interacting with the solvent as the mobile phase.
    Type: Application
    Filed: June 30, 2006
    Publication date: November 2, 2006
    Inventors: Rudolf Krumbholz, Peter Lembke
  • Patent number: 6234464
    Abstract: A microencapsulated unsaturated fatty acid or fatty acid compound or mixture of fatty acids and/or fatty acid compounds, and particularly an omega-3-fatty acid or omega-6-fatty acid or an ethyl ester or a glyceride thereof or a mixture of such fatty acids and/or fatty acid compounds. Fatty acid compounds are understood to include derivatives. Particles of the compounds are provided with capsule walls composed of two layers. The inner layer is composed of gelatin A, gelatine B. casein or an alginate, or of a derivative or salt of one of these polymers. The outer layer is composed of gelatin B, gum arabic, pectin or chitosan or a derivative or salt of one of these polymers.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: May 22, 2001
    Assignee: K.D. Pharma Bexbech GmbH
    Inventors: Rudolf Krumbholz, Alf Lamprecht, Claus-Michael Lehr, Ulrich Schäfer, Norbert Schirra, Manfred Treitz
  • Patent number: 6042840
    Abstract: A urea-containing component of a skin care agent or skin preparation, wherein the urea forms inclusion compounds with fatty acids and/or fatty acid compounds, so that fat is made available for skin care which is protected against oxidation. A method of manufacturing the urea-containing component of a skin care agent includes cooking an oil or a mixture of fatty acid ethyl esters manufactured from an oil with urea in a solvent in a non-oxidizing atmosphere until the urea has been dissolved, permitting the mixture to cool, and finally cooling the mixture to a final temperature of below 10.degree. C. and separating the resulting precipitate.
    Type: Grant
    Filed: March 16, 1998
    Date of Patent: March 28, 2000
    Assignee: K. D. Pharma GmbH
    Inventors: Rudolf Krumbholz, Peter Lembke
  • Patent number: 5362895
    Abstract: A method for recovering at least one unsaturated fatty acid having sixteen or more carbon atoms and/or at least one compound of such a fatty acid from a mixture derived from vegetable, animal or marine sources is provided. Fatty acids and/or fatty acid compounds of the mixture, in free acid or esterified form, are passed into a mobile phase of liquid carbon dioxide in a column over a stationary phase. The stationary phase contains a support and a material bound to the support which contains at least one free electron pair and/or multiple bond. After eluting any saturated fatty acid or fatty acid compound of the same number of carbon atoms from the column, the unsaturated fatty acid and/or fatty acid compound is recovered in pure chemical form or as an enriched mixture.
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: November 8, 1994
    Assignee: K.D. Pharma GmbH
    Inventors: Heinz Engelhardt, Rudolf Krumbholz, Peter Lembke