Abstract: A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed.

Abstract: A disposable injector (4) having a two-chamber system (99), wherein at least one first chamber (105) is part of a piston-cylinder unit (100) that can be accommodated in the disposable injector (4), and wherein the second chamber (255) is part of a chamber (250) which is at least temporarily closed by means of a stopper (257) and inserted into a container adapter (200) detachably mounted on the disposable injector (4), or part of a piston-cylinder unit (254), and wherein the container adapter (200) comprises a connecting tube (242) initially closed by means of a cap (290). To this end, on the side oriented toward the second chamber, the stopper has a recess (271), into which at least one stopper channel (275) connecting the lateral surface (277) of the stopper to the recess (271) opens.

Abstract: A closure system for containers used for storing or administering substances in the form of liquids, pastes or powders that allows the container to be securely closed permanently and in a virus-proof, bacteria-proof and spore-proof manner. The container having an opening that is to be closed, a cap provided with a through-hole, the cap including a substantially cylindrical securing area, and a closure element for sealing the opening. The container includes an end face which surrounds the opening and on which the closure element bears. The closure element comprises a virus-proof, bacteria-proof and spore-proof film, and the cap comprises at least one closed, elastic sealing lip bearing resiliently in a direction towards the closure element in the operative position.

Abstract: A single-use injector comprising a housing (200) accommodating a mechanical spring energy reservoir (50), a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit (80), the spring-locked piston-actuating ram (60) being supported on the housing via support rods, draw hooks or elastic flexural beams. The housing of the injector consists of a thin-walled sheet metal part. Said sheet metal part supports the pretensioned spring energy reservoir and the cylinder/piston unit. The piston (111) of the cylinder/piston unit can be manually displaced by means of a pump rod (140). The single-use injector is compact and has few components, is easy to handle and allows secure storage and functioning. The cylinder/piston unit can be filled when mounted.

Abstract: A disposable injector having a housing (10) in which are arranged at least one mechanical spring energy reservoir (50), at least one cylinder-piston unit (100) that can be filled at least in part with an active substance, at least one piston actuation plunger (60) and at least one trigger unit (80). The spring energy accumulator plunger (60) has at least one tension bar (61) with at least one support surface (63) at the upper end thereof. Locking elements (16) supported on the housing lie on the support surface(s) and are secured in the locking position by a triggering element (82) placed in a locking position (8). The triggering element has a release position (9) that causes the locking element (16) to be unlocked for release of the active substance.

Abstract: A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.

Abstract: The invention relates to a single-use injector and to a two-chamber system, wherein at least one first chamber is part of a cylinder-piston unit that can be received in the single-use injector, and wherein the second chamber is part of a container having at least one opening, and closed at least intermittently by means of a stopper and place in a container adapter releasably supported on the single-use injector. To this end, the stopper and the container adapter can be permanently latched to each other. When the container is inserted, the container adapter closes off the opening and displaces the stopper. When the container is inserted into the container adapter, the adapter connects the interior of the cylinder-piston unit to the interior of the container. By means of the present invention, a single-use injector and a two-chamber system having a reduced number of components is developed.

Abstract: A unidirectional injector having at least one cylinder-piston unit, the piston thereof being displaceable between two stroke end positions relative to the cylinder, wherein the cylinder-piston unit comprises at least one sealing system sealing a compensating space from the surroundings. To this end the piston is provided at its front surface with an axial annular groove for accommodating a seal ring or a permanently elastic seal material, that the cylinder is provided with a first seal element and a second seal element which are spaced by at least a piston stroke, or that the piston is provided with the first seal element and the second seal element which are spaced by at least a piston stroke, or the cylinder carries the first seal element and the piston carries the second seal element which is displaced with respect to the first by the piston stroke.

Abstract: A disposable injector with a housing (10) in which a mechanical spring energy reservoir, a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit are arranged, wherein the spring energy reservoir comprises at least one pretensioned spring element, wherein at least part of the piston-actuating ram is positioned between the spring energy reservoir and the piston of the cylinder/piston unit, and wherein the piston (111) of the cylinder/piston unit is separately moveable via pump rod (140). The pump rod can be coupled releasably to the piston or to a piston rod of the piston. The cylinder of the cylinder/piston unit has a rear sealing element (105) that permits sterile closure of the cylinder interior located between the piston and the cylinder.

Abstract: A single-use injector comprising a housing (200) accommodating a mechanical spring energy reservoir (50), a cylinder/piston unit (100), a piston-actuating ram (60) and a trigger unit (80), the spring-loaded piston-actuating ram being supported on the housing via support rods (240) or draw hooks (250) and each contact zone between an individual support rod or draw hook and the piston-actuating ram representing a wedge gear pairing that forces the respective support rod or draw hook radially outwards. The housing of the injector consists of a thin-walled sheet metal part. Said sheet metal part has at least two limbs (220, 250) arranged parallel to each other. The sheet metal part has at least two pressure bars or at least two draw hooks the free ends of which are bent in an angular fashion to define a supporting section for the piston-actuating ram.

Abstract: A closure system for containers used for storing or administering substances in the form of liquids, pastes or powders that allows the container to be securely closed permanently and in a virus-proof, bacteria-proof and spore-proof manner. The container having an opening that is to be closed, a cap provided with a through-hole, the cap including a substantially cylindrical securing area, and a closure element for sealing the opening. The container includes an end face which surrounds the opening and on which the closure element bears. The closure element comprises a virus-proof, bacteria-proof and spore-proof film, and the cap comprises at least one closed, elastic sealing lip bearing resiliently in a direction towards the closure element in the operative position.

Abstract: A method for preparing a solution from a solvent and an active substance in and on a disposable injector with a housing, with an at least intermittently fillable cylinder/piston unit which is arranged thereon and has a manually movable piston, and with a detachable container adapter mounted upstream of the cylinder/piston unit, wherein the container adapter supports a container which can be filled at least temporarily with active substance and which is closable by an openable stopper.

Abstract: A disposable injector with a housing (10) in which are arranged at least one mechanical spring energy store (50), at least one cylinder-piston unit that can be filled at least temporarily with an active substance, at least one piston actuation plunger (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-loaded spring element. The spring-loaded piston actuation plunger has at least one traction rod (61) which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface (37) of the housing. An actuatable triggering slide device (82) unlocks the disposable injector and releases the supporting portion to allow it to move away from the resting surface.

Abstract: A single-use injector is disclosed comprising a housing (10), arranged in which are at least one mechanical spring energy store (50), at least one piston-cylinder unit (100), which can be effectively filled at least for a certain time, at least one piston-actuating ram (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram (60) has at least one retaining rod or hook (62), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit (80) releases the supporting portion to allow it to move away from the resting surface.

Abstract: The invention relates to a disposable injector with a housing, with a cylinder/piston unit which is arranged thereon and has a manually movable piston, and with a detachable container adapter mounted upstream of this cylinder/piston unit, wherein the container adapter supports a container that is closed by an openable stopper. The piston of the cylinder/piston unit is movable via a pump rod. The container adapter engages at the front end around the cylinder of the piston/cylinder unit. The container adapter has an intermediate floor which supports a dual adapter having at least one through-channel. The container, which bears tightly with its stopper on the dual adapter, sits longitudinally displaceably in the rear of the container adapter. The container is opened by displacing it towards the intermediate floor and pushing the stopper into the container.

Abstract: A closure system is provided for containers used for storing or administering substances in the form of liquids, pastes or powders, which includes a cap, provided with a through-hole, and a closure element, wherein the cap holds the closure element with a force fit and/or form fit on the container, in the area of the container opening that is to be closed, by a catch element present on the container. The end face which surrounds the container opening, and on which the closure element bears, comprises a depression. The closure element is a virus-proof, bacteria-proof and spore-proof film that lies on the end face and, at least in some areas, over the depression. The cap is then fitted in place, an elastomer ring or adhesive ring is arranged between the closure element and the depression and fills the depression.

Abstract: A disposable injector with a housing (10) in which are arranged at least one mechanical spring energy store (50), at least one cylinder-piston unit that can be filled at least temporarily with an active substance, at least one piston actuation plunger (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-loaded spring element. The spring-loaded piston actuation plunger has at least one traction rod (61) which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface (37) of the housing. An actuatable triggering slide device (82) unlocks the disposable injector and releases the supporting portion to allow it to move away from the resting surface.

Abstract: The invention relates to a method of making a solution for injection from a solvent and an active ingredient using a disposable injector with a housing, an injector-side, first cylinder-piston unit—at least intermittently fillable—arranged thereon and an upstream detachable container adapter, wherein the container adapter bears a likewise at least intermittently fillable second cylinder-piston unit. A solvent is stored in the first cylinder-piston unit. In the second cylinder-piston unit there is a freeze-dried active pharmaceutical ingredient. Immediately before use of the disposable injector the solvent is conveyed to the second cylinder-piston unit to the active pharmaceutical ingredient, where a solution forms. This solution is transfer-pumped into the first cylinder-piston unit to then be administered.

Abstract: A cylinder/piston unit is disclosed for pre-fill, storage and release when desired of an active substance, such as a medicament. The cylinder/piston unit is provided with a cylinder and with a piston which is guided therein and which is sealed off in a sterile manner by a rubber seal, the cylinder and the piston enclosing a chamber that can be filled at least temporarily with active substance, and the cylinder having at least one discharge element at its front end. For this purpose, the piston resting in a rear position is sealed off relative to the cylinder in a sterile manner by a static front sealing element and by a static rear sealing element. Arranged spatially behind each static sealing element, there is a parking area for receiving the respective sealing element.

Abstract: A disposable injector with a housing (10) in which are arranged at least one mechanical spring energy store (50), at least one cylinder-piston unit that can be filled at least temporarily with an active substance, at least one piston actuation plunger (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-loaded spring element. The spring-loaded piston actuation plunger has at least one traction rod (61) which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface (37) of the housing. An actuatable triggering slide device (82) unlocks the disposable injector and releases the supporting portion to allow it to move away from the resting surface.