Patents by Inventor Rudolf Merkel

Rudolf Merkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9610254
    Abstract: A molecule mixture comprising an amphipathic molecule of type A, which has an overall positive charge in the hydrophilic region, an amphipathic molecule of type B and a polyphenol C, the method for producing the molecule mixture, and the use thereof. The molecules of types A and B are present at a molecular ratio of A:B of 1(±0.2):1(±0.2) mol/mol. A method for producing the mixture and the use is also disclosed.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: April 4, 2017
    Assignee: Forschungszentrum Juelich GmbH
    Inventors: Agnes Csiszar, Christian Kleusch, Bernd Hoffmann, Rudolf Merkel
  • Publication number: 20170009255
    Abstract: A method for producing a fusion mixture for a transfer of a charged molecule into and/or through a lipid membrane is disclosed. In an embodiment, the method comprises: providing an initial mixture comprising a positively charged amphipathic molecule A, an aromatic molecule B with hydrophobic range and a neutral, amphipathic molecule C, whereby the molecule types are at hand in a ratio A:B:C of 1-2:0.02-1:0-1 mol/mol; generating a fusogenic liposome by absorption of the initial mixture in a watery solvent; providing a charged molecule; forming a complex from the charged molecule and a neutralizing agent; and incubating the complex with the fusogenic liposome so that a fusion mixture is obtained.
    Type: Application
    Filed: July 8, 2016
    Publication date: January 12, 2017
    Inventors: Bernd Hoffmann, Agnes Csiszar, Nils Hersch, Rudolf Merkel, Marco Hoffmann, Roman ZANTL
  • Publication number: 20160060602
    Abstract: The invention relates to a fusion mixture for the lipid-containing membrane modification of an arbitrary target membrane, a cell membrane, a constituent of a cell membrane or a cell membrane separated from remaining cell constituents, in vivo or in vitro, comprising a positively charged amphipathic molecule A and an aromatic molecule B, wherein the molecule of type A and the molecule of type B are present at a ratio A:B of 1:0:02 to 1:2 mol/mol.
    Type: Application
    Filed: March 21, 2014
    Publication date: March 3, 2016
    Inventors: Bernd HOFFMANN, Agnes CSISZAR, Nils HERSCH, Rudolf MERKEL
  • Publication number: 20150037398
    Abstract: A molecule mixture comprising an amphipathic molecule of type A, which has an overall positive charge in the hydrophilic region, an amphipathic molecule of type B and a polyphenol C, the method for producing the molecule mixture, and the use thereof. The molecules of types A and B are present at a molecular ratio of A:B of 1(±0.2):1(±0.2) mol/mol. A method for producing the mixture and the use is also disclosed.
    Type: Application
    Filed: October 1, 2012
    Publication date: February 5, 2015
    Applicant: FORSCHUNGSZENTRUM JÜLICH GMBH
    Inventors: Agnes Csiszar, Christian Kleusch, Bernd Hoffmann, Rudolf Merkel
  • Patent number: 8659407
    Abstract: A sensor unit, in particular a sensor unit in or on a vehicle, for capacitively ascertaining the distance between the sensor device and an object, having an electrode for forming a capacitive system with the object and an apparatus for creating a signal proportional to the capacitance of the capacitive system. The sensor unit has a reference electrode for forming a capacitive reference system with the object, an additional apparatus for creating a reference signal proportional to the capacitance of the capacitive reference system, and an analyzer device for ascertaining the distance by forming a ratio of the signal and the reference signal, the reference electrodes having an electrode shape, which is different from the electrode shape of the electrode.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: February 25, 2014
    Assignee: Robert Bosch GmbH
    Inventors: Rudolf Merkel, Uwe Zimmermann
  • Patent number: 8492701
    Abstract: A measuring station for measuring vehicles has at least one laser source, which emits laser radiation (20) during operation, and a safety system, which includes at least one sensor, which is set up to detect objects. The safety system is configured in such a way that it switches off the laser source when at least one sensor detects an object which approaches a region in which the laser radiation emitted by the laser source has a particularly high intensity.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: July 23, 2013
    Assignee: Robert Bosch GmbH
    Inventors: Guenter Nobis, Steffen Abraham, Matthias Gebhard, Rudolf Merkel, Ulrich Kallmann, Hilaire Gomseu Dioni
  • Patent number: 8310654
    Abstract: A method for the detection of surroundings is performed using a source which emits pulsed signals. Signals backscattered from an object are detected by a sensor. When performing the method, a presence of the object is detected during coarse sampling. To determine a variable related to the detected object, operating parameters of the source are set for fine sampling.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: November 13, 2012
    Assignee: Robert Bosch GmbH
    Inventors: Michael Weilkes, Rudolf Merkel, Uwe Zimmermann
  • Publication number: 20120208229
    Abstract: A device for examining cells comprising an elastomer and the use thereof. The elastomer comprises a bottom and a thicker edge region; and the bottom is provided with regular microstructures. Such elastomers are suitable for stretch experiments, notably of the uniaxial type.
    Type: Application
    Filed: September 25, 2010
    Publication date: August 16, 2012
    Inventors: Wolfgang Rubner, Bernd Hoffmann, Sebastian Houben, Rudolf Merkel
  • Publication number: 20120100077
    Abstract: Disclosed is a mixture of amphipathic molecules and a method for modifying cells in vivo by way of membrane fusion with these molecules.
    Type: Application
    Filed: July 8, 2010
    Publication date: April 26, 2012
    Applicant: FORSCHUNGSZENTRUM JUELICH GMBH
    Inventors: Bernd Hoffmann, Agnes Csiszar, Nils Hersch, Rudolf Merkel
  • Publication number: 20110058581
    Abstract: A measuring station for measuring vehicles has at least one laser source, which emits laser radiation (20) during operation, and a safety system, which includes at least one sensor, which is set up to detect objects. The safety system is configured in such a way that it switches off the laser source when at least one sensor detects an object which approaches a region in which the laser radiation emitted by the laser source has a particularly high intensity.
    Type: Application
    Filed: September 1, 2010
    Publication date: March 10, 2011
    Inventors: Guenter Nobis, Steffen Abraham, Matthias Gebhard, Rudolf Merkel, Ulrich Kallmann, Hilaire Gomseu Dioni
  • Publication number: 20100328056
    Abstract: A sensor unit, in particular a sensor unit in or on a vehicle, for capacitively ascertaining the distance between the sensor device and an object, having an electrode for forming a capacitive system with the object and an apparatus for creating a signal proportional to the capacitance of the capacitive system. The sensor unit has a reference electrode for forming a capacitive reference system with the object, an additional apparatus for creating a reference signal proportional to the capacitance of the capacitive reference system, and an analyzer device for ascertaining the distance by forming a ratio of the signal and the reference signal, the reference electrodes having an electrode shape, which is different from the electrode shape of the electrode.
    Type: Application
    Filed: September 11, 2008
    Publication date: December 30, 2010
    Inventors: Rudolf Merkel, Uwe Zimmermann
  • Publication number: 20090303099
    Abstract: A method for the detection of surroundings is performed using a source which emits pulsed signals. Signals backscattered from an object are detected by a sensor. When performing the method, a presence of the object is detected during coarse sampling. To determine a variable related to the detected object, operating parameters of the source are set for fine sampling.
    Type: Application
    Filed: October 18, 2006
    Publication date: December 10, 2009
    Applicant: Robert Bosch GmbH
    Inventors: Michael Weilkes, Rudolf Merkel, Uwe Zimmermann
  • Publication number: 20090186411
    Abstract: The invention relates to a cell culture apparatus for cells, characterized by a surface composed of an unstructured elastomer. It is thus possible for cells to be cultured under close to natural conditions in relation to their environmental elasticity. A method for producing an apparatus according to the invention is disclosed, as is a cell culture method using such an apparatus.
    Type: Application
    Filed: June 14, 2007
    Publication date: July 23, 2009
    Applicant: Forschungszentrum Juelich GmbH
    Inventors: Bernd Hoffmann, Bodo Borm, Rudolf Merkel
  • Publication number: 20090022896
    Abstract: The invention relates to a method for producing a structured elastomer. The invention is characterised in that the elastomer is applied and hardened directly on a structured SiO2-surface. As a result, highly-deformable, micro-structured elastomers can be produced for force sensors which are used during the characterisation of new therapeutic agents.
    Type: Application
    Filed: February 1, 2006
    Publication date: January 22, 2009
    Inventors: Rudolf Merkel, Bernd Hoffmann, Claudia M. Cesa, Nils Hersch
  • Publication number: 20060064206
    Abstract: A system for detecting objects, in particular for a motor vehicle, is proposed in which, with a radar sensor, the radar signals reflected by the object are processed for ascertaining the distance (d) and/or the relative or approach speed (Cv) of the object. The digital signals from at least one channel (I, Q) of the radar sensor are processed until a first evaluation capability is obtained as a distance signal (d) or as an approach speed signal (Cv), with which it is defined which data are ascertained and will be made available to an interface (6) between the radar sensor and a downstream control unit (7).
    Type: Application
    Filed: October 16, 2003
    Publication date: March 23, 2006
    Inventors: Rudolf Merkel, Uwe Zimmermann, Achim Pruksch, Werner Uhler
  • Patent number: 3978624
    Abstract: Means for terminating the infeed of a machine tool, particularly a grinder. An electrode is imbedded within the tool and is exposed at the active surface thereof, such as the grinding surface of a grinder, and a sensing voltage is placed between said electrode and the workpiece. Suitable switching means is placed within the circuit of said electrode and workpiece which switching means will be activated upon the occurrence of a spark between said electrode and the workpiece. Activation of said switching means then activates further means to terminate the infeed of the tool. The circuitry supplying the voltage aforesaid may include a transformer having a plurality of output taps by which a plurality of voltages may be applied between the electrode and the workpiece and such circuitry will in such case include switching means automatically responsive to said different selected voltages.
    Type: Grant
    Filed: May 7, 1975
    Date of Patent: September 7, 1976
    Assignee: Werkzeugmaschinenfabrik Adolf Waldrich Coburg
    Inventors: Rudolf Merkel, Friedrich Schnell, Ewald Weber
  • Patent number: 3933178
    Abstract: A metering apparatus for liquids containing granular solids, in particular lapping liquid. The stream of liquid issuing from the feed pipe is conveyed with a wide area against a substantially vertical wall, to run down thereon in the form of a thin film of uniform thickness. The collecting pipe is arranged on the side of the wall which is remote from the liquid film. The wall has an orifice therethrough in its lower zone for the free end of the collecting pipe which extends obliquely upwardly. The collecting opening has a cross section which widens with progressive movement of the collecting pipe through the orifice.
    Type: Grant
    Filed: September 9, 1974
    Date of Patent: January 20, 1976
    Assignee: Werkzeugmaschinenfabrik Adolf Waldrich Coburg
    Inventors: Edmund Eich, Ewald Weber, Heinz Gerner, Rudolf Merkel