Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: The invention relates to a battery device (10) for a vehicle, having a main battery system (20) with at least two battery units (BS) and an emergency battery system (30) with at least one battery unit (BS), wherein the main battery system (20) has more battery units (BS) than the emergency battery system (30), wherein the main battery system (20) and the emergency battery system (30) furthermore have the same nominal voltage and are electrically connected in parallel with one another, and the main battery system (20) has a main switch (22) for disconnecting the main battery system (20) and the emergency battery system (30) has an emergency switch (32), separate from the main switch (22), for disconnecting the emergency battery system (30).

Abstract: A method for determining the viscosity of materials uses a rotation viscosimeter having a measuring shaft connected through a coupling element to a drive and a measuring element on a shaft end applied to a sample. An angle measuring unit measures an angle deflection between drive and shaft. The measuring element is immersed in a measuring container containing the sample. The rotational speed of the shaft increases from a first measuring point at an initial speed in steps to further measuring points and the angle deflection between the drive and the shaft is determined in the measuring points. An estimation function is determined for the rotational speed and the angle deflection for the sample using measured values in the measuring points. An optimum rotational speed is determined based on the estimation function of a previously defined optimum angle deflection and the viscosity measurement of the sample is carried out.

Abstract: A method for determining the viscosity of materials uses a rotation viscosimeter having a measuring shaft connected through a coupling element to a drive and a measuring element on a shaft end applied to a sample. An angle measuring unit measures an angle deflection between drive and shaft. The measuring element is immersed in a measuring container containing the sample. The rotational speed of the shaft increases from a first measuring point at an initial speed in steps to further measuring points and the angle deflection between the drive and the shaft is determined in the measuring points. An estimation function is determined for the rotational speed and the angle deflection for the sample using measured values in the measuring points. An optimum rotational speed is determined based on the estimation function of a previously defined optimum angle deflection and the viscosity measurement of the sample is carried out.

Abstract: The present invention relates to the use of ergot derivatives or ergolines, and in particular of lisuride and terguride for the prophylaxis and treatment of constrictive capillary arteriopathy. Constrictive capillary arteriopathy refers to the diseases pulmonary arterial hypertension, endogenously induced or exogenously induced glomerulosclerosis as well as secondary Raynaud's syndrome.

Abstract: The present invention relates to the use of ergot derivatives or ergolines, and in particular of lisuride and terguride for the prophylaxis and treatment of constrictive capillary arteriopathy. Constrictive capillary arteriopathy refers to the diseases pulmonary arterial hypertension, endogenously induced or exogenously induced glomeruloscleroses as well as secondary Raynaud's syndrome.

Abstract: The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.

Abstract: The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.

Abstract: The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.

Abstract: The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.

Abstract: The present invention relates to the use of ergot derivatives or ergolines, and in particular of lisuride and terguride for the prophylaxis and treatment of constrictive capillary arteriopathy. Constrictive capillary arteriopathy refers to the diseases pulmonary arterial hypertension, endogenously induced or exogenously induced glomeruloscleroses as well as secondary Raynaud's syndrome.

Abstract: Many disorders, especially neoplastic disorders such as cancer and polyps, are the result of hyperproliferative cells or of cells with differentiation disorders. For these types of disorders early detection is of pivotal importance and reliable and early biomarkers for common types of cancers such as colorectal cancer are still not available. Thus, there is a need for new markers and for methods for identifying such new markers. The invention provides peptides and proteins and derivatives thereof originating from transcription intermediary factor-1 beta (TIF1-beta) suitable as markers and therapeutics for disorders such as cancer, preferably colorectal cancerous or related disorders such as polyps.

Abstract: The present invention relates to the use of terguride and proterguride for the prophylaxis and/or the treatment of chronic pain conditions as well as to pharmaceutical compositions comprising terguride and/or proterguride optionally together with an opiate analgesic.

Abstract: The invention concerns fluorescein isothiocyanate-sinistrin (FITC-sinistrin), a method for its production, its use as a marker substance in a diagnostic agent and a corresponding diagnostic agent.

Abstract: New dye-polysaccharide and dye-cyclosaccharide conjugates and their use as a diagnostic agent especially for determining the glomerular filtration rate in humans.

Abstract: The invention concerns fluorescein isothiocyanate-sinistrin (FITC-sinistrin), a method for its production, its use as a marker substance in a diagnostic agent and a corresponding diagnostic agent.

Abstract: The invention concerns new bishipidine derivatives, processes for their production and pharmaceutical agents containing these compounds. The new methylene-bishispidine derivatives can be used for the prophylaxis and therapy of late diabetic damage as well as for the prophylaxis and therapy of atherosclerosis and arteriosclerosis.

Abstract: The automatic-assembly bridge, ramp and the like comprises a base segment which has, on one face, two sets of wheels provided with positioning means for disengaging from the ground when the bridge, ramp and the like is installed, as well as an articulation for releasably coupling to a tractor. A second segment is articulated at one end of the base segment and is constituted by a first track and a second track which can be arranged mutually side by side and can be rotated independently from one another so as to be arranged in a transport position, wherein the tracks of the second segment are superimposed on the base segment, and in an installation position, wherein the tracks are arranged substantially along the extension of the base segment. One of the tracks acts as ballast during the rotation of the other track.

Abstract: A cone crusher for crushing stones comprises an outer shroud housing a shaft driven of conical swinging motion at the middle portion whereof there is provided a crushing or milling cone, cooperating with a shroud conical ring to define an upward widening space therebetween, a rotating bush being provided for housing a hydraulic piston supporting, through an axial roller bearing, the bottom end of the shaft arranged substantially concentrical to the piston.