Abstract: The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

Abstract: The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

Abstract: The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC wherein a] a mammalian cell is incubated with glimepiride; b] hcDIGs of the cells of a] are prepared; c] the hcDIGs from b] are incubated with a chemical compound; d] the activity of the GPI-PLC from the hcDIGs of c] is determined.

Abstract: The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade.

Abstract: The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade.

Abstract: In an electromagnetically actuated dual clutch-brake combination (8), a drive input shaft (2) can be optionally engaged in drive connection with a first drive output shaft (4) or with a second drive output shaft (6). The second drive output shaft (6) is associated with an electromagnetic brake (52), which is provided in order to immobilize the second drive output shaft (6), whereas the first drive output shaft (4) can still be connected to the drive input shaft (2) by an electromagnetic clutch (28, 32). The electromagnetic dual clutch-brake combination is suitable for controlling a variable longitudinal differential lock and a shiftable range gear system of an all-wheel distributor gearbox, with only a single electric motor.

Abstract: A device for guiding torque of one drive shaft (3) connected with a driving appliance (2) onto a first or a second output shaft (4, 5). A torque fed via the drive shaft (3) can be applied, respectively, to one of the two output shafts (4, 5) depending on a control of a changeover device (6). The changeover device (6) comprises one electromagnetic clutch (7) which can produce a power flow between the drive shaft (3) and the first or the second output shaft (4 or 5). The electromagnetic clutch (7) comprises a coupling element (8) which is guided and displaced in an axially and rotatable manner and is fixedly connected with the drive shaft (3) and depending on a current supply of the electromagnetic clutch (7) produces the power flow between the drive shaft (3) and the first or the second output shaft (4 or 5).

Abstract: The invention proposes an electromagnetically actuated, single-surface friction coupling without a rotor slip-ring, having a rotor element (2), a fixed magnet body (6) and a pot-shaped armature element (28) mounted so that it can be displaced axially. A cylindrical jacket shaped area (28B) of the armature element (28) extends with a narrow air gap along an outer jacket surface (12) of the magnet body (6). Between the armature element (28) and a friction surface (30) of the rotor element there is a working air gap (S) that can be bridged. To keep the moment of inertia on the drive output side as small as possible, it is proposed to arrange the rotor element (2) on the drive output side and the armature element (28) on the drive input side.

Abstract: The invention refers to a protein from plasma membrane of adipocytes. The protein has specific binding affinity to phosphoinositoylglycans. It regulates glucose uptake by circumventing the insulin signaling cascade.

Abstract: In an electromagnetically actuated dual clutch-brake combination (8), a drive input shaft (2) can be optionally engaged in drive connection with a first drive output shaft (4) or with a second drive output shaft (6). The second drive output shaft (6) is associated with an electromagnetic brake (52), which is provided in order to immobilize the second drive output shaft (6), whereas the first drive output shaft (4) can still be connected to the drive input shaft (2) by an electromagnetic clutch (28, 32). The electromagnetic dual clutch-brake combination is suitable for controlling a variable longitudinal differential lock and a shiftable range gear system of an all-wheel distributor gearbox, with only a single electric motor.

Abstract: The invention proposes an electromagnetically actuated, single-surface friction coupling without a rotor slip-ring, having a rotor element (2), a fixed magnet body (6) and a pot-shaped armature element (28) mounted so that it can be displaced axially. A cylindrical jacket shaped area (28B) of the armature element (28) extends with a narrow air gap along an outer jacket surface (12) of the magnet body (6). Between the armature element (28) and a friction surface (30) of the rotor element there is a working air gap (S) that can be bridged. To keep the moment of inertia on the drive output side as small as possible, it is proposed to arrange the rotor element (2) on the drive output side and the armature element (28) on the drive input side.

Abstract: The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

Abstract: A device for guiding torque of one drive shaft (3) connected with a driving appliance (2) onto a first or a second output shaft (4, 5). A torque fed via the drive shaft (3) can be applied, respectively, to one of the two output shafts (4, 5) depending on a control of a changeover device (6). The changeover device (6) comprises one electromagnetic clutch (7) which can produce a power flow between the drive shaft (3) and the first or the second output shaft (4 or 5). The electromagnetic clutch (7) comprises a coupling element (8) which is guided and displaced in an axially and rotatable manner and is fixedly connected with the drive shaft (3) and depending on a current supply of the electromagnetic clutch (7) produces the power flow between the drive shaft (3) and the first or the second output shaft (4 or 5).

Abstract: The invention is based on an electromagnetic hysteresis unit (1, 23) with magnetic north pole (4) which are arranged to alternate with magnetic south pole (5) on a magnet body (2, 3) in a peripheral direction (15) about an axis of rotation (14) at a distance from the magnetic south poles (5). The magnet body (2, 3) comprises a magnet coil (6). A hysteresis ring (16) connected with a rotor (17) can be moved with a slight play in relation to the poles (4, 5). It is proposed that the peripheral surfaces of the north pole (4) and south pole (5) lie on the same circle and opposite the same peripheral surface of the hysteresis ring (16). Thereby is created a radial construction space for embedding the hysteresis ring (16) in the rotor (17) which consists of material of good heat conductivity and optionally for providing cooling ribs.

Abstract: The invention relates to a hysteresis brake comprising a hysteresis ring (1) which is rotationally fixed to a roller (9), and a magnetic ring with magnetic poles. The magnetic ring (2) is made of permanent magnetic material and is mounted inside the hysteresis ring (1), wherein the magnetic poles are alternately along the external circumference of the magnet ring (2). The magnetic ring (2) encloses a supporting member (4), which is mounted in a rotationally secured position but which can be axially displaced around the axis by means of a regulating device (7).

Abstract: The invention relates to a method for the case-hardening of higher-molybdenum-alloy sintered steels.It is provided that, immediately after the sintering, the sintered steels are cooled down to a temperature range at which a minimum portion of .gamma.-iron is present in sintered steel and that the sintered steels are subjected to a heat treatment in this temperature range in the presence of carbon.

Abstract: An electromagnetic hysteresis brake is provided with a two-part pole ring with an inner and an outer pole ring part (5, 6) and a field coil (10) and further provided with a rotating ring (3) made of a permanent-magnetic material, the ring (3) projects into an annular air gap (11) of the pole ring which is formed between the inner and the outer pole ring parts (5, 6), at least one of the air gaps (12) of the brake is adjustable.

Abstract: A multifunctional RNA having self-processing activity, the preparation thereof and the use thereof Host cells can be transformed so that they express ribozyme RNA and antisense RNA which are connected with each other via a spacer. The RNA molecules can, for example, be complementary to a certain viral RNA. Plants which have been transformed with genes coding for RNA of this type show a significantly improved resistance to viruses.

Abstract: Virus genes, such as coat protein genes, which confer viral resistance or bring about a reduction in the signs of infection by the corresponding virus can be combined with herbicide-resistance genes, such as the phosphinothricin resistance gene, for the transformation of plants. A combination of a viral gene and a herbicide-resistance gene facilitates the selection of transgenic plants. In addition, in practical field cultivation, the vitality of the plants is increased by the virus tolerance, and an improved plant protection is possible due to the herbicide resistance gene.

Abstract: A multifunctional RNA having self-processing activity, the preparation thereof and the use thereof.Host cells can be transformed so that they express ribozyme RNA and antisense RNA which are connected with each other via a spacer. The RNA molecules can, for example, be complementary to a certain viral RNA. Plants which have been transformed with genes coding for RNA of this type show a significantly improved resistance to viruses.