Patents by Inventor Rudolf Van Der Pol

Rudolf Van Der Pol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CYCLOPEPTIDE FERMENTATION AT INCREASED METAL ION CONCENTRATION
    Publication number: 20140349345
    Abstract: The present invention relates to a method for the fermentation of cyclopeptides such as pneumocandins in the presence of increased concentrations of any or all of calcium, copper, iron, magnesium, manganese, molybdenum and zinc ions.
    Type: Application
    Filed: January 7, 2013
    Publication date: November 27, 2014
    Inventors: Wouter Adrianus Van Winden, Rudolf Van Der Pol
  • STABILIZED ENZYME COMPOSITIONS
    Publication number: 20120164708
    Abstract: The present invention relates to a composition comprising an enzyme and octanol. Additionally, the present invention relates to a composition comprising a transition metal ion.
    Type: Application
    Filed: June 15, 2010
    Publication date: June 28, 2012
    Inventors: Willem Bijleveld, Rudolf Van Der Pol, Roeland Christiaan Vollinga
  • Nucleic acid sequences encoding enantioselective amidases
    Patent number: 7241602
    Abstract: The invention relates to nucleic acid sequence encoding enantioselective amides with an amino acid sequence of SEQ ID NO: 2. The invention also relates to a process for fermentation, comprising a batch and a feed phase, of a microorganism in a fermentation medium, wherein the microorganism expresses a nucleic acid according to the invention and wherein between 0.5 and 50 mg of Zn2+/ml of fermentation medium is fed during the fermentation. The invention also relates to a process for the preparation of enatiomerically enriched carboxylic acid and/or an enatiomerically enriched carboxylic acid amide, in which a mixture of corresponding D- and L-carboxylic acid amides is contacted with a expression product according to the invention in the presence of 0.01 mM–100 mM Zn2+, whereby one of the enantiomers of the carboxylic acid amide is enatiomerically hydrolysed to from corresponding enatiomerically enriched carboxylic acid, while the other enantiomer of the carboxylic acid amide remains unchanged.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: July 10, 2007
    Assignee: DSM IP Assets B.V.
    Inventors: Theodorus Sonke, Renate Francisca Tandler, Cornelis Gerrit Nijs Korevaar, Friso Bernard Jan Van Assema, Rudolf Van Der Pol
  • Nucleic acid sequences encoding enantioselective amidases
    Publication number: 20050079595
    Abstract: The invention relates to a nucleic acid sequence encoding an enantioselective amidase with an amino acid sequence, which amino acid sequence has at least 70% identity with SEQ ID NO: 2. The invention also relates to a prcoess for the fermentation, comprising a batch and a feed phase, of a microorganism in a fermentation medium, wherein the microorganism expresses a nucleic acid according to the invention and wherein between 0.5 and 50 mg/l_fermentation medium Zn2+ is fed during the fermentation. The invention also relates to a process for the preparation of an enantiomerically enriched carboxylic acid and/or an enantiomerically enriched carboxylic acid amide, in which a mixture of the corresponding D- and L-carboxylic acid amides is contacted with an expression product according to the invention in the presence of between 0.
    Type: Application
    Filed: July 15, 2002
    Publication date: April 14, 2005
    Inventors: Theodorus Sonke, Renate Tandler, Cornelis Korevaar, Friso Van Assema, Rudolf Van Der Pol