Abstract: An optical arrangement of the Michelson interferometer type having a measuring arm for measuring optical properties of at least two mutually spaced regions in an optically transparent and/or diffusive object. A reference arm has a path length variation unit which generates a periodic change in path length for the radiation in the reference arm. Arranged in the measuring arm upstream of the object is a detour unit. The detour unit imparts a detour which is larger than at least one second measuring beam into at least one measuring beam. The detour unit selects a detour to be equal to a distance between regions to be measured in the object. Using the optical arrangement the object is irradiated with the aid of a number of measuring beams corresponding to the number of regions. In each case two measuring beams have an optical path difference which corresponds to a geometrical distance between two regions.

Abstract: The present invention relates to a positively charged virosome for efficient delivery of genetic material to resting or proliferating mammalian cells in vitro and in vivo. The virosome membrane contains cationic and/or polycationic lipids, at least one viral fusion peptide and preferably at least one cell-specific marker, advantageously selected from the group consisting of monoclonal antibodies, antibody fragments F(ab′)2 and Fab′, cytokines, and growth factors, for a selective detection and binding of target cells. The invention further relates to a method for the manufacture of the novel virosomes and to applications thereof, particularly for the manufacture of pharmaceutical compositions to treat cancer or leukemia.

Abstract: The phospholipid bilayer contains at least one pharmaceutically active drug and comprises cell-specific markers on the membrane which have at least 90% biological activity when measured according to Luescher & Glueck, Antiviral Research 14, 39-50. In the membrane, the cholesterol content is preferably less than 2% by weight, the detergent content preferably less than 1 ppb. The vesicle diameter preferably is about 80 nm. the phospholipid in the membrane may comprise 70 to 95% by weight of phosphatidylcholine and preferably 10 to 20% by weight of phosphatidylethanolamine; preferably 6-8% by weight of a crosslinker, preferably of a sulfosuccinimidyl derivate, and at least one cell-specific fusion peptide are linked to the membrane. The vesicles are used for the preparation of pharmaceuticals against AIDS and carcinomas.