Abstract: A method and an apparatus for producing a block for a plate heat exchange is described wherein partition plates and heat-conducting structures are stacked together with brazing material in a block, and the block is subjected to a first force in the vertical direction. A first, upper section of the block is heated to a brazing-material softening temperature, and at the same time, a second section of the block is brought to a tempering temperature which is lower than the brazing-material softening temperature. Subsequently, the block is not subjected to any force from the outside or is subjected to a second force which is lower than the first force, and the second section of the block is brought to a brazing-material softening temperature. At the same time, the first section is brought to a tempering temperature which is lower than the brazing-material softening temperature.

Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.

Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.

Abstract: The invention describes a method for producing a plate heat exchanger 1. Wavy profiled sheets 9 and separating sheets 10, together with sidebars 11, are stacked one above the other, provided with solder and soldered together in such a way that a block 2 is obtained. The block is closed off outwardly by means of the cover sheets 12. The contours of the intermediate pieces 3 are milled out at the respective positions 4 on the block 2 thus obtained. In a refinement of the invention, frames are used as intermediate pieces 3. The frames 3 are positioned in the milled-out portions at the positions 4, provided with solder and tacked on by means of spot welding. Subsequently, in a second step, the frames 3 are soldered onto the heat exchanger block 2. The headers 5a and 5b are in each case welded onto the frames 3.

Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.

Abstract: The invention relates to a distribution system (1) for distributing a fluid (15) into a container (27) from a fluid inlet (26) of the container (27). Distribution system (1) comprises one or more guide plates that form a guide section (2) and a distribution section (3) that adjoins the guide section (2). Distribution section (3) has regions (4, 5) with openings (8, 9) for allowing fluid (17) to pass through. The invention also relates to a heat exchanger device (100) that has a container (27) with a fluid inlet (26), with at least one heat exchanger block (28) that is arranged in the container (27). A distribution system (101) according to the invention is arranged in the container (27) above the heat exchanger block (28).

Abstract: The invention relates to a distribution system (1) for distributing a fluid (15) into a container (27) from a fluid inlet (26) of the container (27). Distribution system (1) comprises one or more guide plates that form a guide section (2) and a distribution section (3) that adjoins the guide section (2). Distribution section (3) has regions (4, 5) with openings (8, 9) for allowing fluid (17) to pass through. The invention also relates to a heat exchanger device (100) that has a container (27) with a fluid inlet (26), with at least one heat exchanger block (28) that is arranged in the container (27). A distribution system (101) according to the invention is arranged in the container (27) above the heat exchanger block (28).

Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.

Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.

Abstract: The invention describes a method for producing a plate heat exchanger 1. Wavy profiled sheets 9 and separating sheets 10, together with sidebars 11, are stacked one above the other, provided with solder and soldered together in such a way that a block 2 is obtained. The block is closed off outwardly by means of the cover sheets 12. The contours of the intermediate pieces 3 are milled out at the respective positions 4 on the block 2 thus obtained. In a refinement of the invention, frames are used as intermediate pieces 3. The frames 3 are positioned in the milled-out portions at the positions 4, provided with solder and tacked on by means of spot welding. Subsequently, in a second step, the frames 3 are soldered onto the heat exchanger block 2. The headers 5a and 5b are in each case welded onto the frames 3.

Abstract: The invention relates to the use of peripheral-blood mononuclear cells that have been stimulated via cascade priming (CAPRI cells) for the purpose of providing an agent for the treatment of cancerous diseases. The CAPRI cells may also be administered in combination with CD3-activated cells.

Abstract: The invention describes a plate heat exchanger and a method for producing a plate heat exchanger. The plate heat exchanger consists of a multiplicity of passages 1a, 1b which are arranged in stack form and which are separated from one another by separating sheets 2. The passages 1a and 1b in this case consist of a multiplicity of hollow profiles 5 arranged next to one another.

Abstract: The present invention relates to the use of a diuretic, especially a loop diuretic, for the treatment of local skin swellings. The invention further relates to pharmaceutical preparations of diuretics in topical form.

Abstract: The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or RNA or DNA or cDNA, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases.

Abstract: The invention relates to the use of peripheral-blood mononuclear cells that have been stimulated via cascade priming (CAPRI cells) for the purpose of providing an agent for the treatment of cancerous diseases. The CAPRI cells may also be administered in combination with CD3-activated cells.

Abstract: A cellular method for typing lymphocyte defined human leukocyte antigens by utilizing human blood leukocytes which have been sensitized to proliferatively respond to the secondary stimulus of the leukocyte antigens to which they have been sensitized. The sensitization is accomplished by incubating, in vitro, in a mixed leukocyte culture, the leukocytes to be sensitized with leukocytes differing by only a single major histocompatibility complex haplotype or a single HLA-D antigenic determinant.