Patents by Inventor Rudolph L. Leibel

Rudolph L. Leibel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating Prader-Willi syndrome
    Patent number: 11957656
    Abstract: The present invention relates to methods for regulating prohormone convertase (PC1) and compounds and treatments which increase PC1 levels, for treating Prader-Willi Syndrome (PWS).
    Type: Grant
    Filed: October 26, 2020
    Date of Patent: April 16, 2024
    Assignees: The Trustees of Columbia University in the City of New York, Levo Therapeutics, Inc.
    Inventors: Lisa Cole Burnett, Dieter Egli, Rudolph L Leibel, Sara Cotter
  • METHODS OF TREATING PRADER-WILLI SYNDROME
    Publication number: 20210113521
    Abstract: The present invention relates to methods for regulating prohormone convertase (PC1) and compounds and treatments which increase PC1 levels, for treating Prader-Willi Syndrome (PWS).
    Type: Application
    Filed: October 26, 2020
    Publication date: April 22, 2021
    Inventors: Lisa Cole BURNETT, Dieter EGLI, Rudolph L. LEIBEL, Sara COTTER
  • Methods of treating Prader-Willi syndrome
    Patent number: 10842775
    Abstract: The present invention relates to methods for regulating prohormone convertase (PC1) and compounds and treatments which increase PC1 levels, for treating Prader-Willi Syndrome (PWS).
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: November 24, 2020
    Assignees: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, LEVO THERAPEUTICS, INC.
    Inventors: Lisa Cole Burnett, Dieter Egli, Rudolph L. Leibel, Sara Cotter
  • METHODS OF TREATING PRADER-WILLI SYNDROME
    Publication number: 20190298686
    Abstract: The present invention relates to methods for regulating prohormone convertase (PC1) and compounds and treatments which increase PC1 levels, for treating Prader-Willi Syndrome (PWS).
    Type: Application
    Filed: June 2, 2017
    Publication date: October 3, 2019
    Applicants: The Trustees of Columbia University in the City of New York, Levo Therapeutics, Incs, Inc.
    Inventors: Lisa Cole BURNETT, Dieter EGLI, Rudolph L. LEIBEL, Sara COTTER
  • METHOD FOR GENERATING BETA CELLS
    Publication number: 20180237751
    Abstract: The invention is directed to methods for generating pancreatic progenitor cells, insulin producing cells or endoderm cells using embryonic stem cells and induced pluripotent stem cells.
    Type: Application
    Filed: September 21, 2017
    Publication date: August 23, 2018
    Inventors: Haiqing HUA, Dieter EGLI, Rudolph L. LEIBEL, Linshan SHANG
  • Methods of treating metabolic disease
    Patent number: 9682123
    Abstract: The invention provides methods for treating metabolic disease in a subject and methods for increasing the expression of ILDR2 in a subject. The invention further provides a method for identifying an agent which modulates expression of an Ildr2 RNA comprising contacting a cell with an agent; determining expression of the Ildr2 RNA in the presence and the absence of the agent; and comparing expression of the Ildr2 RNA in the presence and the absence of the agent, wherein a change in the expression of the Ildr2 RNA in the presence of the agent is indicative of an agent which modulates the level of expression of the RNA.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: June 20, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Rudolph L. Leibel, Kazuhisa Watanabe, Wendy K. Chung, Stuart G. Fischer, Charles Leduc, Elizabeth Watson, Maria Laura Cremona
  • METHODS OF TREATING METABOLIC DISEASE
    Publication number: 20150190466
    Abstract: The invention provides methods for treating metabolic disease in a subject and methods for increasing the expression of ILDR2 in a subject. The invention further provides a method for identifying an agent which modulates expression of an Ildr2 RNA comprising contacting a cell with an agent; determining expression of the Ildr2 RNA in the presence and the absence of the agent; and comparing expression of the Ildr2 RNA in the presence and the absence of the agent, wherein a change in the expression of the Ildr2 RNA in the presence of the agent is indicative of an agent which modulates the level of expression of the RNA.
    Type: Application
    Filed: December 22, 2014
    Publication date: July 9, 2015
    Inventors: Rudolph L. LEIBEL, Kazuhisa WATANABE, Wendy K. CHUNG, Stuart G. FISCHER, Charles LEDUC, Elizabeth WATSON, Maria Laura CREMONA
  • METHOD FOR GENERATING BETA CELLS
    Publication number: 20140242038
    Abstract: The invention is directed to methods for generating pancreatic progenitor cells, insulin producing cells or endoderm cells using embryonic stem cells and induced pluripotent stem cells.
    Type: Application
    Filed: January 17, 2014
    Publication date: August 28, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Haiqing HUA, Dieter EGLI, Rudolph L. LEIBEL, Linshan SHANG
  • METHODS FOR IDENTIFYING COMPOUNDS THAT MODULATE LISCH-LIKE PROTEIN OR C1ORF32 PROTEIN ACTIVITY AND METHODS OF USE
    Publication number: 20130160150
    Abstract: The invention provides methods for reducing diabetes susceptibility in a subject and methods for increasing the expression of LL or CLORF32 in a subject. The invention further provides a method for identifying an agent which modulates expression of an Ll RNA or Clorf32 RNA comprising contacting a cell with an agent; determining expression of the Ll RNA or Clorf32 RNA in the presence and the absence of the agent; and comparing expression of the Ll RNA or Clorf32 RNA in the presence and the absence of the agent, wherein a change in the expression of the Ll RNA or Clorf32 RNA in the presence of the agent is indicative of an agent which modulates the level of expression of the RNA.
    Type: Application
    Filed: December 12, 2008
    Publication date: June 20, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Rudolph L. Leibel, Wendy K. Chung, Charles LeDuc, Stuart G. Fischer, Chouinard Roland
  • Mahoganoid polypeptides, and related compositions and methods
    Patent number: 7339028
    Abstract: This invention provides an isolated mahoganoid polypeptide. This invention also provides an isolated mahoganoid nucleic acid, as well as related nucleic acids, pharmaceutical compositions, antibodies, assay methods, therapeutic methods and articles of manufacture.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: March 4, 2008
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Rudolph L. Leibel, Wendy K. Chung, Loan K. Phan
  • Mahoganoid polypeptides, and related compositions and methods
    Publication number: 20040053303
    Abstract: This invention provides an isolated mahoganoid polypeptide. This invention also provides an isolated mahoganoid nucleic acid, as well as related nucleic acids, pharmaceutical compositions, antibodies, assay methods, therapeutic methods and articles of manufacture.
    Type: Application
    Filed: June 6, 2003
    Publication date: March 18, 2004
    Inventors: Rudolph L. Leibel, Wendy K. Chung, Loan K. Phan