Patents by Inventor Rudolph Lucas

Rudolph Lucas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TNF-alpha muteins and a process for preparing them
    Patent number: 5891679
    Abstract: The invention relates to tumor necrosis factor muteins characterized in that the TNF-.alpha. amino acid sequence is mutated, or deleted totally or partially, in the region containing position 101 to 116 in such a way that:either the lectin-like activity is reduced with respect to TNF-.alpha.,or the toxic activity is reduced with respect to TNF-.alpha.; and providing that said muteins have largely retained the tumoricidal activity of TNF-.alpha.; and with said muteins possibly containing in their peptidic chain additional modifications consisting of substitutions and/or deletions and/or additions of one or several amino acid residues, and with said muteins being characterized in that they have retained the aforementioned activities; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 15, 1995
    Date of Patent: April 6, 1999
    Assignee: N.V. Innogenetics S.A.
    Inventors: Rudolph Lucas, Patrick De Baetselier, Lucia Fransen, Erwin Sablon