Patents by Inventor Rudolph Willem

Rudolph Willem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tin polyoxaalkanecarboxylates and compositions containing them
    Patent number: 6407265
    Abstract: Tin polyaalkanecarboxylates having the formula [(R1pR2qSn)rOs]t wherein R1 represents C1-C6 alkyl, branched or straight, substituted or not by one or more hydroxyl groups or halogen atoms, or a phenyl group, substituted or not by one or more hydroxyl groups or halogen atoms, R2 is carboxylic residue selected from (I), (II), (III) or (IV); and p, q, r, s and t have the following meanings: P=3, q=1, r=1, s=) and t=1, p=2, q=2, r=1, s=0, and t=1, p=2, q=1, r=2, s=1 and t=2, have anti-tumor activity.
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: June 18, 2002
    Assignee: Pharmachemie B.V.
    Inventors: Marcel Gielen, Rudolph Willem, Monique Biesemans, Martine Kemmer, Dick de Vos
  • Tin polyoxaalkanecarboxylates and compositions containing them
    Publication number: 20010039270
    Abstract: Tin polyaalkanecarboxylates having the formula [(R1pR2qSn)rOs]t wherein R1 represents C1-C6 alkyl, branched or straight, substituted or not by one or more hydroxyl groups or halogen atoms, or a phenyl group, substituted or not by one or more hydroxyl groups or halogen atoms, R2 is carboxylic residue selected from (I), (II), (III) or (IV); and p, q, r, s and t have the following meanings: P=3, q=1, r=1, s=) and t=1, p=2, q=2, r=1, s=0, and t=1, p=2, q=1, r=2, s=1 and t=2, have anti-tumor activity.
    Type: Application
    Filed: January 29, 2001
    Publication date: November 8, 2001
    Inventors: Marcel Gielen, Rudolph Willem, Monique Biesemans, Martine Kemmer, Dick de Vos
  • Dibutyltin bis(dihydroxybenzoates) and compositions containing these compounds
    Patent number: 5583157
    Abstract: This invention provides novel Sn compounds, i.e. di-n.butyltindihydroxybenzoates, which exhibit excellent activities against varies tumors. This invention also provides pharmaceutical compositions which contain said novel Sn compounds in combination with a suitable carrier, in particular aqueous solutions which are suitable for injection.
    Type: Grant
    Filed: April 12, 1995
    Date of Patent: December 10, 1996
    Assignee: Pharmachemie B.V.
    Inventors: Marcel Gielen, Rudolph Willem, Abdeslam Bouhdid, Dick de Vos
  • Aromatic fluorine-containing organotin compounds and anti-tumour composition
    Patent number: 5559147
    Abstract: The invention relates to novel aromatic fluorine-containing organotin compounds of the formula {(F.sub.5 C.sub.6 RCO.sub.2 SnBu.sub.2).sub.2 O}.sub.2 and {(F.sub.5 C.sub.6 RCO.sub.2).sub.2 SnBu.sub.2 } wherein R is CH.sub.2, CH.dbd.CH or a single bond between the phenyl ring and the CO.sub.2 group, and Bu is a butyl group; as well as to anti-tumour compositions containing as an active ingredient one or more of these compounds.
    Type: Grant
    Filed: August 24, 1995
    Date of Patent: September 24, 1996
    Assignee: Pharmachemie B.V.
    Inventors: Marcel Gielen, Rudolph Willem, Abdeslam Bouhdid, Dick de Vos
  • Organo-tin compounds having anti-tumour activity and anti-tumour compositions
    Patent number: 5382597
    Abstract: The invention relates to anti-tumor compositions containing as an active ingredient one or more compounds of the formulaAr.sub.3 Sn--O--C(O)--C.sub.6 H.sub.2 XYZwherein X and Y are each H, OH, halogen or alkyl; and Z is halogen, amino, alkoxy, acyloxy, sulphonic acid or alkyl. A number of these compounds are novel compounds.
    Type: Grant
    Filed: October 1, 1992
    Date of Patent: January 17, 1995
    Assignee: Pharmachemie B.V.
    Inventors: Mohammad Boualam, Marcel Gielen, Abdelaziz El Khloufi, Dirk De Vos, Rudolph Willem