Abstract: Preventive as well as therapeutic treatment to alleviate the symptoms of disturbed keratinization, consisting of the topical application of a solution, gel, lotion, cream, ointment, stick, powder or spray containing one or more cysteic acid compounds, is disclosed. The compounds include free acid, ammonium salt, amine salt, metal chelate and metallic salt forms of cysteic acid, cysteine sulfinic acid and homocysteic acid. The efficacious compositions may include the active ingredients present in a total amount of from 0.1 to 30 percent by weight. Topical application to affected areas has been found to achieve from a substantial to a complete remission of dry skin, keratoses, warts and palmar and plantar hyperkeratosis. Used as a hair dressing, the compositions have been found to give the hair excellent grooming and luster.

Abstract: A treatment to alleviate the symptoms of psoriasis consisting of topical application of a cream, lotion, ointment or gel containing as the principal active ingredient one or more nicotinamide analogues is disclosed. The therapeutic composition may include a single member of the above active ingredients present in a total amount of from 0.01 to 5 percent by weight of the total composition or a plurality thereof present in a preferred concentration range of from 0.02 to 2 percent by weight of the total composition. Topical application of the therapeutic composition in a cream, ointment, lotion, water or gel has been found to achieve from substantial to complete remissions of psoriasis in humans.

Abstract: Stabilized water-in-oil emulsions useful as vehicles for cosmetics and for therapeutic compositions to be topically applied is disclosed. The emulsions utilize a concentration of from 0.001 to 0.9% by weight of at least one of the aluminum containing compound as a primary emulsion stabilizer. A stable water-in-oil emulsion may also be formulated by utilizing from 0.001 to 0.2% of magnesium hydroxide or magnesium oxide as a primary emulsion stabilizer. This emulsion may be acidified to a desired pH with secondary emulsion stabilizer such as phosphoric acid, metallic chloride or metallic chlorohydroxide.

Abstract: Composition and method for enhancing therapeutic effects of corticosteroids to alleviate the symptoms of inflammation and exfoliation such as psoriasis, eczema, seborrheic dermatitis and other inflammatory skin conditions consisting of a solution, cream, lotion, ointment or gel containing as two active ingredients a corticosteroid and an additive are disclosed. The therapeutic composition may include one or more of corticosteroids typically present in a total amount of from 0.01 to 2 percent and one or more of hydroxy acids or related compounds present in a total amount from 0.01 to 2 percent by weight of the total composition. Topical application of the therapeutic composition in a solution, cream, lotion, gel or ointment has been found to achieve a substantial increase in antiinflammatory action of corticosteroids.

Abstract: Preventive as well as therapeutic treatment to alleviate the symptoms of skin keratoses consisting of topical application of a solution, gel, lotion, cream or ointment containing one or more of the .alpha.- or .beta.-hydroxy acids or .alpha.-keto acids, esters thereof, and their amine salts is disclosed. The compounds include free acid or amine salt forms of .alpha.-hydroxy-butyric acid, .alpha.-hydroxyisobutyric acid, .alpha.-hydroxyisocaproic acid, .alpha.-hydroxyisovaleric, atrolactic acid, .beta.-hydroxybutyric acid, .beta.-phenyl lactic acid, .beta.-phenylpyruvic acid, citric acid, ethyl pyruvate, galacturonic acid, glucoheptonic acid, glucoheptono 1,4-lactone, gluconic acid, gluconolactone, glucuronic acid, glucuronolactone, glycolic acid, isopropyl pyruvate, lactic acid, malic acid, mandelic acid, methyl pyruvate, mucic acid, pyruvic acid, saccharic acid, saccharic acid 1,4-lactone, tartaric acid, and tartronic acid.

Abstract: A thermistor composition containing zinc oxide, manganese oxide, and cobalt oxide in selected ternary ratios together with small portions of titanium oxide. The titanium oxide addition to the selected ternary ratios of the other three oxides provides a more constant temperature coefficient (beta) over a range of about 300.degree. F. that includes room temperature.

Abstract: Preventive as well as therapeutic treatment to alleviate the symptoms of disturbed keratinization, consisting of the topical application of a solution, gel, lotion, cream, ointment, stick, powder or spray containing one or more cysteic acid compounds, is disclosed. The compounds include free acid, ammonium salt, amine salt, metal chelate and metallic salt forms of cysteic acid, cysteine sulfinic acid and homocysteic acid. The efficacious compositions may include the active ingredients present in a total amount of from 0.1 to 30 percent by weight. Topical application to affected areas has been found to achieve from a substantial to a complete remission of dry skin, keratoses, warts and palmar and plantar hyperkeratosis. Used as a hair dressing, the compositions have been found to give the hair excellent grooming and luster.

Abstract: Compositions and methods for treating the symptoms of psoriasis consisting of topical application of a solution, gel, lotion, cream or ointment containing as a principal active ingredient one or more retinoyl compounds is disclosed. The active ingredient consists of one or more compounds which are retinoyl esters of a hydroxy acid, a hydroxy amide, or a hydroxy acid ester, or a retinoyl carbamic or thiocarbamic acid derivative. The composition of this invention may include a single member of the above active ingredients present in a total amount of from 0.01 to 5% by weight of the total composition, or a plurality thereof present in a preferred concentration of from 0.02 to 2% by weight of the total composition.

Abstract: Preventive as well as therapeutic treatment to alleviate the symptoms of disorders characterized by cracking, flaking or scaling of the skin consisting of the topical application of a lotion, cream or ointment containing one or more of the .alpha.- or .beta.-hydroxy acids or .alpha.-keto acids and esters thereof, their amides and their ammonium salts is disclosed. The compounds include free acid, amide and/or ammonium salt forms of citric acid, glycolic acid, glucuronic acid, galacturonic acid, glucuronolactone, gluconolactone, .alpha.-hydroxybutyric acid, .alpha.-hydroxyisobutyric acid, lactic acid, malic acid, mandelic acid, mucic acid, pyruvic acid, methyl pyruvate, ethyl pyruvate, .beta.-phenyllactic acid, .beta.-phenylpyruvic acid, saccharic acid, tartaric acid, tartronic acid, and .beta.-hydroxybutyric acid. The therapeutic composition may include one or more of the compounds present in the total amount of from one to twenty percent.

Abstract: Discloses .alpha.-hydroxyretinoic acid, .alpha.-ketoretinoic acid and mixtures thereof as well as compositions containing the same that are useful in the treatment of skin diseases, and particularly skin diseases exhibiting abnormal keratinization.

Abstract: A treatment to alleviate the symptoms of psoriasis consisting of topical application of a cream, ointment or lotion containing, as the principal active ingredient, one or more 6-substituted nicotinamides and or 2-substituted pyrazinamides is disclosed. The therapeutic composition may include a single member of the above active ingredients present in a total amount of from 0.01 to 5 percent by weight of the total composition, or a plurality thereof present in a preferred concentration range of from 0.02 to 2 percent by weight of the total composition. Topical application of the therapeutic composition in a cream, ointment, or a water or alcohol solution has been found to achieve from substantial to complete remissions of psoriasis in humans.

Abstract: Preventive as well as therapeutic treatment to alleviate the symptoms of disorders characterized by cracking, flaking or scaling of the skin consisting of the topical application of a lotion, cream or ointment containing one or more of the .alpha.- or .beta.-hydroxy acids or .alpha.-keto acids and esters thereof, their amides and their ammonium salts is disclosed. The compounds include free acid, amide and/or ammonium salt forms of citric acid, glycolic acid, glucoronic acid, galacturonic acid, glucuronolactone, gluconolactone, .alpha.-hydroxybutyric acid, .alpha.-hydroxyisobutyric acid, lactic acid, malic acid, mandelic acid, mucic acid, pyruvic acid, methyl pyruvate, ethyl pyruvate, .beta.-phenyllactic acid, .beta.-phenylpyruvic acid, saccharic acid, tartaric acid, tartronic acid, and .beta.-hydroxybutyric acid. The therapeutic composition may include one or more of the compounds present in the total amount of from one to twenty percent.

Abstract: Preventive as well as therapeutic treatment to alleviate the symptoms of diseases characterized by defects in keratinization consisting of the topical application of a solution, lotion, cream or shampoo containing one or more of the .alpha.-hydroxy or .alpha.-keto acid amides and/or ammonium salts is disclosed. The compounds include amide and/or ammonium salt forms of citric acid, glycolic acid, glucuronic acid, galacturonic acid, glucuronolactone, gluconolactone, .alpha.-hydroxybutyric acid, .alpha.-hydroxyisobutyric acid, malic acid, mandelic acid, pyruvic acid, .beta.-phenyllactic acid, .beta.-phenylpyruvic acid, saccharic acid, tartaric acid, tartronic acid and .beta.-hydroxybutyric acid. The therapeutic composition may include one or more of the compounds present in a total amount of from 1 to 20 percent. Topical application to affected areas has been found to achieve from a substantial to a complete remission of dandruff and acne.

Abstract: A treatment to alleviate the symptoms of psoriasis consisting of topical application of a cream, ointment or lotion containing as an active ingredient one or more of the following compounds: 6-aminonicotinamide, 6-carbamoylnicotinamide, 6-chloronicotinamide, 6-dimethylaminonicotinamide, 6-formylaminonicotinamide, 6-aminonicotinic acid, 6-aminonicotinic acid methyl ester, 6-hydroxy nicotinic acid, thionicotinamide, 2-aminopyrazinamide and 2-carbamoylpyrazinamide is disclosed. The therapeutic composition may include a single member of the above listed active ingredients present in a total amount of from 0.01 to 5 percent by weight of the total composition, or a plurality thereof present in a preferred concentration range of from 0.01 to 2 percent by weight of the total composition. Topical application of the therapeutic composition in a cream, ointment, or a water or alcohol solution has been found to achieve from substantial to complete remissions of psoriasis in humans.

Abstract: A treatment to prevent the symptoms of skin conditions characterized by an offensive odor of the body, and a treatment to alleviate the symptoms of diseases characterized by defects of keratinization consisting of the topical application of a solution, lotion, cream, ointment, powder, stick or spray containing cysteic acid, cysteinesulfinic acid, homocysteic acid or their metal chelates are disclosed. The metal chelates include molecular complexes of cysteic acid or its analogue and metal ions such as ferric, cupric, zinc and aluminum ions. The efficacious compositions may include the active ingredients present in a total amount of from 1 to 30 percent, and preferably from 2 to 10 percent by weight. In a prophylactic treatment topical application to skin areas of axilla, crotch (inguinalperineum) and feet has been found to prevent the formation of malodor.

Abstract: Preventive as well as therapeutic treatment of acne vulgaris (hereafter referred to as acne) consisting of the topical application of a solution, lotion or cream containing N-methyldiethanolamine is disclosed. Topical application to uninvolved or involved skin has been found to achieve respectively a complete prevention or a substantial remission of acne.

Abstract: A treatment to alleviate the symptoms of actinic or nonactinic keratoses consisting of topical application of a solution, lotion, cream or ointment containing retinal is disclosed. The therapeutic composition may include retinal as an active ingredient present in an amount of from 0.01 to 2 percent by weight of the total composition. Topical application of the therapeutic composition in a solution, lotion, cream or ointment has been found to achieve from substantial to complete remissions of the keratoses in humans.

Abstract: Preventive as well as therapeutic treatment of acne vulgaris (hereafter referred to as acne) consisting of the topical application of a solution, lotion or cream containing one or more than one of the lactamides and/or quaternary ammonium lactates is disclosed. Topical application to uninvolved or involved skin has been found to achieve respectively a complete prevention or a substantial remission of acne.

Abstract: A composition and method for producing pigmentation in skin or hair by topical application is described. The composition comprises as active ingredients one or more esters of DOPA wherein the esterifying radical is an alkyl, aryl or alkylene radical having up to 12 carbon atoms, or methyl dopate. The pigmentation producing ester is dissolved in a pharmaceutically acceptable vehicle which may be alkaline, neutral or acidic, and may contain peroxides or other oxidizing agents. Skin treated by topical application of the composition of this invention has been found to be protected against sun burn and against erythema from ultraviolet light in proportion to the extent of the pigmentation produced.

Abstract: A treatment to alleviate the symptoms of diseases characterized by defects in keratinization consisting of the topical application of an ointment or lotion containing one or more lower aliphatic compounds having from two to about six carbon atoms, and preferably having .alpha.-carbon functionality is disclosed. The compounds include .alpha.-hydroxy acids, keto acids and esters thereof, and 3-hydroxybutyric acid. The therapeutic composition may include one or more of the compounds present in a total amount of from one to twenty percent in either a water or alcohol solution or an ointment. Topical application to affected areas has been found to achieve a complete remission of dandruff, acne and palmar and plantar hyperkeratosis.