Patents by Inventor Ruey-shyan Liou

Ruey-shyan Liou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Humanized anti-TNF? antibodies
    Patent number: 8658171
    Abstract: The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: February 25, 2014
    Assignee: Livzon Mabpharm Inc.
    Inventors: Baoguo Zhu, Desheng Tao, Bill Nai-Chau Sun, Lee-Hwei King Sun, Ruey Shyan Liou, Cecily Rou-Yun Sun, Qiang Li, Yucai Peng, Jingwei Zhang, Zhenxiang Hu
  • Fc fusion proteins of human growth hormone
    Patent number: 8637637
    Abstract: Fc fusion proteins of human growth hormone with good biological activities relative to rhGH on a molar basis are disclosed. The hGH-L-vFc fusion protein comprises hGH, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The Fc variant is of a non-lytic nature and shows minimal undesirable Fc-mediated side effects. A method is also disclosed to make or produce such fusion proteins at high expression levels. Such hGH-L-vFc fusion proteins exhibit extended or prolonged serum half-life and/or good biological activities relative to that of rhGH on a molar basis, leading to improved pharmacokinetics and pharmacodynamics, thus fewer injections will be needed within a period of time.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: January 28, 2014
    Inventors: Bill Nai-Chau Sun, Ruey-shyan Liou, Cecily Rou-Yun Sun, Lee-Hwei King Sun
  • Humanized Anti-TNFalpha Antibodies
    Publication number: 20120219547
    Abstract: The present invention provides a humanized anti-TNF monoclonal antibody and the use thereof. The humanized anti-TNF monoclonal antibody significantly reduces the immunogenicity of murine-antibody while retaining the ability of antibody to recognize antigen, compared with conservative mouse chimeric antibody. Therefore, safety of the antibody in clinical applications has been improved.
    Type: Application
    Filed: February 24, 2012
    Publication date: August 30, 2012
    Inventors: Baoguo Zhu, Desheng Tao, Bill Nai-Chau Sun, Lee-Hwei King Sun, Ruey Shyan Liou, Cecily Rou-Yun Sun, Qiang Li, Yucai Peng, Jingwei Zhang, Zhenxiang Hu
  • Fc fusion proteins of human growth hormone
    Publication number: 20120116056
    Abstract: Fc fusion proteins of human growth hormone with good biological activities relative to rhGH on a molar basis are disclosed. The hGH-L-vFc fusion protein comprises hGH, a flexible peptide linker of about 20 or fewer amino acids, and a human IgG Fc variant. The Fc variant is of a non-lytic nature and shows minimal undesirable Fc-mediated side effects. A method is also disclosed to make or produce such fusion proteins at high expression levels. Such hGH-L-vFc fusion proteins exhibit extended or prolonged serum half-life and/or good biological activities relative to that of rhGH on a molar basis, leading to improved pharmacokinetics and pharmacodynamics, thus fewer injections will be needed within a period of time.
    Type: Application
    Filed: January 12, 2010
    Publication date: May 10, 2012
    Inventors: Bill Nai-Chau Sun, Ruey-shyan Liou, Cecily Rou-Yun Sun, Lee-Hwei King Sun