Abstract: Disclosed in the present invention is a method for synthesizing high-purity plant-derived cholesterol. By taking plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, also called bisnoralcohol or BA, as a raw material, cholesterol is synthesized by means of steps such as oxidation, Wittig reaction, acetylation, reduction and selective hydrogenation reduction, or the cholesterol is synthesized by means of steps such as oxidation, Wittig reaction, acetylation, reduction, hydroxyl protection, selective hydrogenation reduction, deprotection or hydrolysis, and the purity can reach 99% or above.

Abstract: Disclosed in the present invention is a synthesis method for high-purity cholesterol. The cholesterol is synthesized by using plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, which is also referred to as bisnoralcohol or BA, as a raw material, and by means of steps of oxidation, Wittig reaction, acetylation, reduction, hydroxyl protection, selective hydrogenation reduction, and deprotection or hydrolysis reaction, and the purity can reach 99% or above. Aiming at defects of conventional animal-derived cholesterol, in the present invention, the cholesterol is synthesized from plant-derived raw material BA; thus, high safety is achieved, the risk of pathogenic bacteria and virus infection is avoided, high synthesis yield, high product purity, and environmental friendliness are achieved, and industrial production is facilitated.