Patents by Inventor Ruhong Zhou
Ruhong Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11786525Abstract: A high-efficiency anti-tumor nano-drug delivery system containing hydralazine (hydralazine-nanoparticles abbreviated as H-NPs) is provided. The drug delivery system takes hydralazine and doxorubicin combined by a ?-? bond as a hydrophobic core and takes dextran as a hydrophilic shell. The high-effective anti-tumor nano-drug delivery system containing hydralazine can increase the vascular permeability and blood perfusion of the tumor site, improve the enrichment and penetration of nanoparticles in the tumor, reduce tumor hypoxia, increase the sensitivity of the tumor to a chemotherapy drug doxorubicin, and significantly improve its anti-tumor effect by expanding the tumor blood vessels and regulating tumor microenvironment (TME).Type: GrantFiled: March 2, 2023Date of Patent: October 17, 2023Assignee: SHANGHAI INSTITUTE FOR ADVANCED STUDY ZHE JIANG UNIVERSITYInventors: Ruhong Zhou, Lianxue Zhang
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Publication number: 20220249548Abstract: Application of carbon-based nanomaterial in the preparation of drug for alleviating or treating HD. The carbon-based nanomaterial was prepared from the vitamin or quasi-vitamins.Type: ApplicationFiled: July 17, 2020Publication date: August 11, 2022Inventors: Zaixing YANG, Xiuhua YIN, Zhenhui KANG, Ruhong ZHOU
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Publication number: 20220230702Abstract: A computer-implemented method for executing a computation task in a molecular dynamic simulation includes identifying a bonding target on a ligand; constructing a protein structure; rendering an image of the ligand; subsampling data pertaining to the constructed protein structure and the image of the ligand at a particular frequency; rendering a two-dimensional image of the constructed protein structure relative to the ligand from a plurality of viewpoints; computing optical flows of the protein structure relative to the ligand based on the two-dimensional image; analyzing the optical flows to determine a displacement of atoms; simulating a binding state outcome of the protein structure relative to the ligand for each of the plurality of viewpoints; and predicting a probability of the protein structure binding with the ligand, based on the predicted binding state outcome for each of the plurality of viewpoints.Type: ApplicationFiled: January 21, 2021Publication date: July 21, 2022Inventors: Giacomo Domeniconi, Leili Zhang, Guojing Cong, Chih-Chieh Yang, Ruhong Zhou
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Publication number: 20220115086Abstract: Altering protein-ligand structures by generating molecular trajectory data for a protein-ligand structure, determining a molecular level binding affinity according to the molecular trajectory data, determining an atom level binding affinity for a first atom of the protein-ligand structure according to the molecular trajectory data, determining a correlation between the atom level and the molecular level binding affinities, and altering the protein-ligand structure according to the correlation.Type: ApplicationFiled: October 8, 2020Publication date: April 14, 2022Inventors: Giacomo Domeniconi, Leili Zhang, Guojing Cong, Chih-Chieh Yang, Ruhong Zhou
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Patent number: 10281428Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.Type: GrantFiled: November 3, 2016Date of Patent: May 7, 2019Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Patent number: 9995710Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.Type: GrantFiled: April 28, 2016Date of Patent: June 12, 2018Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Publication number: 20170067853Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.Type: ApplicationFiled: November 3, 2016Publication date: March 9, 2017Inventors: BINQUAN LUAN, RUHONG ZHOU
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Patent number: 9588080Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.Type: GrantFiled: August 15, 2013Date of Patent: March 7, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Patent number: 9541541Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged molecule to pass but to block a protein molecule attached to a ligand connecting to the charged molecule, the opening being filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged molecule through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged molecules passing into the opening. The current changes are employed to trigger a bias field increase to cause separation between the ligand and the protein to infer an interaction strength.Type: GrantFiled: April 30, 2013Date of Patent: January 10, 2017Assignee: GLOBALFOUNDRIES INC.Inventors: Binquan Luan, Ruhong Zhou
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Patent number: 9534253Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: GrantFiled: February 6, 2015Date of Patent: January 3, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Patent number: 9528153Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: GrantFiled: February 6, 2015Date of Patent: December 27, 2016Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Patent number: 9518294Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: GrantFiled: February 6, 2015Date of Patent: December 13, 2016Assignee: International Business Machines CorporationInventors: Binquan Luan, Ruhong Zhou
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Patent number: 9428804Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: GrantFiled: August 20, 2013Date of Patent: August 30, 2016Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Patent number: 9428803Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: GrantFiled: December 21, 2012Date of Patent: August 30, 2016Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Publication number: 20160238559Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.Type: ApplicationFiled: April 28, 2016Publication date: August 18, 2016Inventors: BINQUAN LUAN, RUHONG ZHOU
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Patent number: 9372171Abstract: A nanosensor for detecting molecule characteristics includes a membrane having an opening configured to permit a charged carbon nanotube to pass but to block a molecule attached to the carbon nanotube. The opening is filled with an electrolytic solution. An electric field generator is configured to generate an electric field relative to the opening to drive the charged carbon nanotubes through the opening. A sensor circuit is coupled to the electric field generator to sense current changes due to charged carbon nanotubes passing into the opening, and to bias the electric field generator to determine a critical voltage related to a force of separation between the carbon nanotube and the molecule.Type: GrantFiled: April 30, 2013Date of Patent: June 21, 2016Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Binquan Luan, Ruhong Zhou
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Patent number: 9311360Abstract: A method for associating data with a target biological sequence includes identifying, in a network, one or more references to data, where the data has a relevance level greater than a predetermined threshold. The method includes associating the one or more references to one or more probe sequences corresponding to a segment of a biological sequence to which the data pertains The one or more probe sequences are ranked based on one or more criteria and the probe sequences are assigned a level of affinity to a segment of the target biological sequence based at least on the ranking of each reference.Type: GrantFiled: November 29, 2012Date of Patent: April 12, 2016Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: James R. Kozloski, Clifford A. Pickover, Jacinta M. Wubben, Ruhong Zhou
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Publication number: 20150159209Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: ApplicationFiled: February 6, 2015Publication date: June 11, 2015Inventors: Binquan Luan, Ruhong Zhou
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Publication number: 20150153309Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: ApplicationFiled: February 6, 2015Publication date: June 4, 2015Inventors: Binquan Luan, Ruhong Zhou
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Publication number: 20150153305Abstract: A mechanism is provided for ratcheting a double strand molecule. The double strand molecule is driven into a Y-channel of a membrane by a first voltage pulse. The Y-channel includes a stem and branches, and the branches are connected to the stem at a junction. The double strand molecule is slowed at the junction of the Y-channel based on the first voltage pulse being weaker than a force required to break a base pair of the double strand molecule. The double strand molecule is split into a first single strand and a second single strand by driving the double strand molecule into the junction of the Y-channel at a second voltage pulse.Type: ApplicationFiled: February 6, 2015Publication date: June 4, 2015Inventors: Binquan Luan, Ruhong Zhou